ENSMUSG00000038910


Mus musculus

Features
Gene ID: ENSMUSG00000038910
  
Biological name :Plcl2
  
Synonyms : Inactive phospholipase C-like protein 2 / Plcl2 / Q8K394
  
Possible biological names infered from orthology : phospholipase C like 2 / Q9UPR0
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 50509547
Gene end: 50688493
  
Corresponding Affymetrix probe sets: 10445867 (MoGene1.0st)   1426450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046584
NCBI entrez gene - 224860     See in Manteia.
MGI - MGI:1352756
RefSeq - XM_006524153
RefSeq - NM_013880
RefSeq - XM_006524151
RefSeq - XM_006524152
RefSeq - XM_006524150
RefSeq Peptide - NP_038908
swissprot - Q8K394
Ensembl - ENSMUSG00000038910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcl2ENSDARG00000098826Danio rerio
 PLCL2ENSGALG00000011248Gallus gallus
 PLCL2ENSG00000154822Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834961
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905531
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683428
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617326
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066025
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496024
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006124
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117724
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093724
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994323
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028382  Inactive phospholipase C-like protein 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002337 B-1a B cell differentiation IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IGI
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IGI
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050859 negative regulation of B cell receptor signaling pathway IMP
 biological_processGO:1900122 positive regulation of receptor binding IGI
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0050811 GABA receptor binding ISO
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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