ENSMUSG00000010660


Mus musculus

Features
Gene ID: ENSMUSG00000010660
  
Biological name :Plcd1
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / Plcd1 / Q8R3B1
  
Possible biological names infered from orthology : P51178 / phospholipase C delta 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119071527
Gene end: 119093502
  
Corresponding Affymetrix probe sets: 10597575 (MoGene1.0st)   1416675_s_at (Mouse Genome 430 2.0 Array)   1448432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010804
Ensembl peptide - ENSMUSP00000149676
Ensembl peptide - ENSMUSP00000149813
NCBI entrez gene - 18799     See in Manteia.
MGI - MGI:97614
RefSeq - XM_006511984
RefSeq - NM_001293648
RefSeq - NM_019676
RefSeq Peptide - NP_001280577
RefSeq Peptide - NP_062650
swissprot - Q05DG3
swissprot - Q8R3B1
swissprot - G5DDB7
Ensembl - ENSMUSG00000010660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcd1aENSDARG00000059123Danio rerio
 plcd1bENSDARG00000034080Danio rerio
 PLCD1ENSGALG00000005805Gallus gallus
 PLCD1ENSG00000187091Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093750
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617344
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905539
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683437
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834937
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891037
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023033
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994332
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496032
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117731
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006129


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028391  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0060716 labyrinthine layer blood vessel development IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IDA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Plcd1tm1Tta/olt
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJOrl * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ezh2tm2.1Sho/Ezh2tm2.1Sho
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0003414 epidermal cyst "a cyst formed of a mass of epidermal cells which is present beneath the epidermis; the wall is lined with stratified squamous epithelium and exhibits increased/abnormal keratinization" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plcd1tm1Tta/Plcd1tm1Tta
Genetic Background: involves: 129P2/OlaHsd

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013378 increased sebocyte number "greater than expected number of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation" [MGI:Anna, PMID:19944183]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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