ENSMUSG00000036834


Mus musculus

Features
Gene ID: ENSMUSG00000036834
  
Biological name :Plch1
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Plch1 / Q4KWH5
  
Possible biological names infered from orthology : phospholipase C eta 1 / Q4KWH8
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E1
Gene start: 63696234
Gene end: 63899472
  
Corresponding Affymetrix probe sets: 10498448 (MoGene1.0st)   1457157_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135353
Ensembl peptide - ENSMUSP00000125581
Ensembl peptide - ENSMUSP00000135424
Ensembl peptide - ENSMUSP00000135562
Ensembl peptide - ENSMUSP00000047693
Ensembl peptide - ENSMUSP00000058524
Ensembl peptide - ENSMUSP00000081122
Ensembl peptide - ENSMUSP00000123921
Ensembl peptide - ENSMUSP00000124463
Ensembl peptide - ENSMUSP00000124491
Ensembl peptide - ENSMUSP00000124632
NCBI entrez gene - 269437     See in Manteia.
MGI - MGI:2683547
RefSeq - XM_017319601
RefSeq - XM_006501541
RefSeq - XM_011240131
RefSeq - XM_011240133
RefSeq - XM_011240134
RefSeq - XM_017319593
RefSeq - XM_017319594
RefSeq - XM_017319595
RefSeq - XM_017319596
RefSeq - XM_017319597
RefSeq - XM_017319598
RefSeq - XM_017319599
RefSeq - XM_017319600
RefSeq - NM_001177732
RefSeq - NM_001177733
RefSeq - NM_183191
RefSeq - XM_006501530
RefSeq - XM_006501531
RefSeq - XM_006501533
RefSeq - XM_006501535
RefSeq - XM_006501536
RefSeq - XM_006501537
RefSeq - XM_006501538
RefSeq Peptide - NP_899014
RefSeq Peptide - NP_001171203
RefSeq Peptide - NP_001171204
swissprot - H3BKX1
swissprot - I1E4X4
swissprot - I1E4X6
swissprot - E0CZ95
swissprot - Q4KWH5
swissprot - A0A0A0MQM2
swissprot - E0CY47
swissprot - H3BKE1
swissprot - H3BKK4
Ensembl - ENSMUSG00000036834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plch1ENSDARG00000079253Danio rerio
 PLCH1ENSGALG00000010312Gallus gallus
 PLCH1ENSG00000114805Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905542
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834920
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891019
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496017
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617317
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093717
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006116
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066016
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994316
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117716
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028392  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
 IPR028393  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050429 calcium-dependent phospholipase C activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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