ENSMUSG00000040061


Mus musculus

Features
Gene ID: ENSMUSG00000040061
  
Biological name :Plcb2
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / A3KGF7 / Plcb2
  
Possible biological names infered from orthology : phospholipase C beta 2 / Q00722
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 118707517
Gene end: 118728438
  
Corresponding Affymetrix probe sets: 10486119 (MoGene1.0st)   1452481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124364
Ensembl peptide - ENSMUSP00000099583
NCBI entrez gene - 18796     See in Manteia.
MGI - MGI:107465
RefSeq - XM_017316359
RefSeq - NM_001290790
RefSeq - NM_177568
RefSeq - XM_017316357
RefSeq Peptide - NP_001277719
RefSeq Peptide - NP_808236
swissprot - E9PYI3
swissprot - A3KGF7
Ensembl - ENSMUSG00000040061
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLCB2ENSDARG00000090381Danio rerio
 PLCB2ENSGALG00000042105Gallus gallus
 PLCB2ENSG00000137841Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117747
Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*ENSMUSG0000002496045
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994334
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905523
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891023
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683423
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834921
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093720
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617320
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066019
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028403  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0050913 sensory perception of bitter taste IMP
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Acetylcholine regulates insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001985 abnormal gustatory system physiology "anomalous perception of taste" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0001986 taste sensitivity/ preferences 
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129S1/Sv

 MP:0002409 decreased susceptibility to infection "reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0004209 abnormal sweet taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0004210 abnormal bitter taste sensitivity "changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0009449 increased platelet ATP level "increased concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0011678 abnormal vomeronasal sensory neuron physiology "any functional anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
Show

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039943 Plcb4 / phospholipase C, beta 4 / Q15147*  / reaction
 ENSMUSG00000040061 Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*  / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000024960 Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*  / reaction
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000051177 Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*  / reaction
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / reaction / complex
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / reaction / complex
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / reaction / complex






 

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