ENSMUSG00000024960


Mus musculus

Features
Gene ID: ENSMUSG00000024960
  
Biological name :Plcb3
  
Synonyms : P51432 / phospholipase C, beta 3 / Plcb3
  
Possible biological names infered from orthology : Q01970
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6953714
Gene end: 6969759
  
Corresponding Affymetrix probe sets: 10465521 (MoGene1.0st)   1448661_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025912
NCBI entrez gene - 18797     See in Manteia.
MGI - MGI:104778
RefSeq - XM_006526767
RefSeq - NM_001290349
RefSeq - NM_008874
RefSeq - XM_006526766
RefSeq Peptide - NP_001277278
RefSeq Peptide - NP_032900
swissprot - P51432
Ensembl - ENSMUSG00000024960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcb3ENSDARG00000068246Danio rerio
 PLCB3ENSG00000149782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*ENSMUSG0000005117754
Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*ENSMUSG0000004006143
Plcb4 / phospholipase C, beta 4 / Q15147*ENSMUSG0000003994336
Plch2 / A2AP18 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 / O75038* / phospholipase C eta 2*ENSMUSG0000002905523
Plch1 / Q4KWH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 / Q4KWH8* / phospholipase C eta 1*ENSMUSG0000003683423
Plcl2 / Q8K394 / Inactive phospholipase C-like protein 2 / Q9UPR0* / phospholipase C like 2*ENSMUSG0000003891022
Plcl1 / Q3USB7 / Inactive phospholipase C-like protein 1 / Q15111* / phospholipase C like 1 (inactive)*ENSMUSG0000003834921
Plcd1 / Q8R3B1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 / P51178* / phospholipase C delta 1*ENSMUSG0000001066020
Plcd4 / Q8K3R3 / phospholipase C, delta 4 / Q9BRC7*ENSMUSG0000002617319
Plcd3 / Q8K2J0 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 / Q8N3E9* / phospholipase C delta 3*ENSMUSG0000002093719
Plcz1 / Q8K4D7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 / Q86YW0* / phospholipase C zeta 1*ENSMUSG0000003023017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR014815  Phospholipase C-beta, C-terminal domain
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR016280  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Synthesis of IP3 and IP4 in the cytosol
Acetylcholine regulates insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G beta:gamma signalling through PLC beta
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Presynaptic function of Kainate receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004270 analgesia "inability to sense pain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0009449 increased platelet ATP level "increased concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040061 Plcb2 / A3KGF7 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 / Q00722* / phospholipase C beta 2*  / reaction
 ENSMUSG00000024960 Plcb3 / P51432 / phospholipase C, beta 3 / Q01970*  / reaction
 ENSMUSG00000051177 Plcb1 / Q9Z1B3 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 / Q9NQ66* / phospholipase C beta 1*  / reaction
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / reaction / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000039943 Plcb4 / phospholipase C, beta 4 / Q15147*  / reaction
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / reaction / complex
 ENSMUSG00000001985 Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*  / complex / reaction






 

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