MP:0000030 | abnormal tympanic ring morphology | "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0000104 | abnormal sphenoid bone morphology | "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0000198 | hypophosphatemia | "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0000295 | poorly developed ventricular trabeculae | "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0000440 | domed skull | |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0000575 | dark foot pads | "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator] |
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0000678 | abnormal parathyroid gland morphology | "anomalous structure of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0000681 | abnormal thyroid gland morphology | "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000811 | hippocampal neuron degeneration | "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0001188 | hyperpigmentation | "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0001562 | abnormal circulating calcium level | "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0001951 | abnormal breathing | "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002249 | abnormal larynx morphology | "any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002591 | decreased mean corpuscular volume | "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki
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MP:0002823 | abnormal rib development | "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0002843 | decreased blood pressure | "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0002876 | abnormal thyroid physiology | "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002896 | abnormal bone mineralization | "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0002904 | increased circulating parathyroid hormone level | "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0002951 | small thyroid gland | "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0002985 | abnormal urine calcium level | "any change in the level of excretion of calcium in the urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm2Soff/Gnaqtm2Soff,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaq+,Tg(PTH-cre)4167Slib/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0003026 | decreased vascular smooth muscle contraction | "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0003056 | abnormal hyoid bone | "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0003071 | decreased vascular permeability | "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/? Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
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MP:0003235 | abnormal alisphenoid bone morphology | "malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0003503 | decreased activity of thyroid | |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003996 | clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0004452 | abnormal pterygoid process morphology | "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0004486 | decreased response of heart to induced stress | "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki
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MP:0004609 | vertebral fusion | "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0004697 | abnormal thyroid follicular cell | "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004876 | decreased mean arterial blood pressure | "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0004883 | abnormal blood vessel healing | "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0005039 | hypoxia | "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0005122 | increased circulating thyroid-stimulating hormone level | "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0005249 | abnormal palatine bone morphology | "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0005270 | abnormal zygomatic bone morphology | "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0005406 | abnormal heart size | "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0005409 | darkened coat color | "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0005441 | hypercalciuria | "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0005478 | decreased circulating thyroxine level | "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Abcg1tm1Dgen/Abcg1tm1Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005498 | hyporesponsive to tactile stimuli | "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0005567 | decreased circulating total protein level | "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0005574 | decreased breathing frequency | "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0005591 | decreased vasodilation | "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0005597 | decreased susceptibility to type I hypersensitivity reaction | "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Tg(Tek-cre/ERT2)1Soff/? Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
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MP:0006395 | abnormal epiphyseal plate morphology | "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0008805 | decreased circulating amylase level | "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1a(EUCOMM)Wtsi/Gna11tm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1a(EUCOMM)Wtsi/Cnrm
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MP:0008974 | proportional dwarf | "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0009142 | decreased prepulse inhibition | "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0010326 | malleus hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0010432 | common ventricle | "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0010640 | ventricular myocardium compact layer hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * C57BL/6
Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr Genetic Background: involves: 129P2/OlaHsd
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MP:0011276 | increased tail pigmentation | "visually detectable excess of pigment present on the tail surface" [MGI:csmith] |
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0011278 | increased ear pigmentation | "visually detectable excess of pigment present in the outer ear" [MGI:csmith] |
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Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0012045 | increased susceptibility to hypertension | "more likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [MGI:Nicole] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0013279 | increased fasted circulating glucose level | "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza] |
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H
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MP:0020106 | decreased nitrate level | "decreased level of nitrate ion in fluids and tissues" [GOC:NV] |
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Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N
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MP:0030029 | wide cranial sutures | "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537] |
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Allelic Composition: CrygdLop12/CrygdLop12 Genetic Background: involves: BALB/cJ * SJL/J
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MP:0030107 | incus hypoplasia | "underdevelopment or reduced size, usually due to reduced cell number, of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [MGI:anna] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0030128 | stapes hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the stirrup-shaped ossicle that is the smallest and innermost of the three auditory ossicles" [MGI:anna] |
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Allelic Composition: Gna11tm1Soff/Gna11+,Gnaqtm1Soff/Gnaqtm1Soff Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0030299 | lower jaw to upper jaw transformation | "homeotic transformation of lower jaw (mandibular) elements into upper jaw-like (maxillary) structures" [MGI:anna, PMID:22560091] |
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Allelic Composition: Kcnk3tm1.1Daba/Kcnk3tm1.1Daba,Kcnk9tm1.1Daba/Kcnk9tm1.1Daba Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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