ENSMUSG00000061751


Mus musculus

Features
Gene ID: ENSMUSG00000061751
  
Biological name :Kalrn
  
Synonyms : A2CG49 / Kalirin / Kalrn
  
Possible biological names infered from orthology : kalirin RhoGEF kinase / O60229
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 33974258
Gene end: 34573532
  
Corresponding Affymetrix probe sets: 10439138 (MoGene1.0st)   1429796_at (Mouse Genome 430 2.0 Array)   1436066_at (Mouse Genome 430 2.0 Array)   1440970_at (Mouse Genome 430 2.0 Array)   1442341_at (Mouse Genome 430 2.0 Array)   1442554_s_at (Mouse Genome 430 2.0 Array)   1448023_at (Mouse Genome 430 2.0 Array)   1457690_at (Mouse Genome 430 2.0 Array)   1457899_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110611
Ensembl peptide - ENSMUSP00000110604
Ensembl peptide - ENSMUSP00000110612
Ensembl peptide - ENSMUSP00000123416
Ensembl peptide - ENSMUSP00000116188
Ensembl peptide - ENSMUSP00000110624
Ensembl peptide - ENSMUSP00000110617
Ensembl peptide - ENSMUSP00000110615
Ensembl peptide - ENSMUSP00000110614
Ensembl peptide - ENSMUSP00000076088
Ensembl peptide - ENSMUSP00000087084
Ensembl peptide - ENSMUSP00000110597
Ensembl peptide - ENSMUSP00000110599
Ensembl peptide - ENSMUSP00000110603
NCBI entrez gene - 545156     See in Manteia.
MGI - MGI:2685385
RefSeq - XM_017317082
RefSeq - XM_017317071
RefSeq - XM_017317072
RefSeq - XM_017317073
RefSeq - XM_017317074
RefSeq - XM_017317075
RefSeq - XM_017317076
RefSeq - XM_017317077
RefSeq - XM_017317078
RefSeq - XM_017317079
RefSeq - XM_017317080
RefSeq - XM_017317081
RefSeq - NM_001164268
RefSeq - NM_177357
RefSeq - XM_006522363
RefSeq - XM_006522364
RefSeq - XM_006522370
RefSeq - XM_006522380
RefSeq - XM_006522381
RefSeq - XM_006522382
RefSeq - XM_006522383
RefSeq - XM_006522385
RefSeq - XM_006522386
RefSeq - XM_011245951
RefSeq - XM_011245952
RefSeq - XM_011245953
RefSeq - XM_011245954
RefSeq - XM_011245955
RefSeq - XM_011245956
RefSeq - XM_011245957
RefSeq - XM_011245958
RefSeq - XM_011245959
RefSeq - XM_011245960
RefSeq - XM_011245961
RefSeq - XM_011245963
RefSeq - XM_011245965
RefSeq - XM_011245966
RefSeq - XM_011245967
RefSeq - XM_011245968
RefSeq - XM_011245969
RefSeq - XM_011245970
RefSeq Peptide - NP_796331
RefSeq Peptide - NP_001157740
swissprot - D3Z534
swissprot - D3Z532
swissprot - D3Z4R2
swissprot - D3Z560
swissprot - F6QYT9
swissprot - A2CG49
swissprot - A0A0A0MQF1
swissprot - B1B1A7
swissprot - D3Z535
Ensembl - ENSMUSG00000061751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FP015810.1ENSDARG00000112749Danio rerio
 kalrnaENSDARG00000104119Danio rerio
 kalrnbENSDARG00000063538Danio rerio
 KALRNENSGALG00000011744Gallus gallus
 KALRNENSG00000160145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*ENSMUSG0000002226377
Mcf2l / MCF.2 cell line derived transforming sequence like / O15068*ENSMUSG000000314429
Mcf2 / MCF.2 cell line derived transforming sequence / P10911*ENSMUSG000000311398
Arhgef25 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant 3, mRNA. / Q86VW2* / Rho guanine nucleotide exchange factor 25*ENSMUSG000000194672
Q4VAC9 / Plekhg3 / Pleckstrin homology domain-containing family G member 3 / A1L390* / pleckstrin homology and RhoGEF domain containing G3*ENSMUSG000000526091
Plekhg1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSMUSG000000406241
Plekhg2 / pleckstrin homology and RhoGEF domain containing G2 / Q9H7P9*ENSMUSG000000375521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018159  Spectrin/alpha-actinin
 IPR028569  Kalirin
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009612 response to mechanical stimulus IMP
 biological_processGO:0014909 smooth muscle cell migration IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0046959 habituation IMP
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0048659 smooth muscle cell proliferation IDA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060125 negative regulation of growth hormone secretion IMP
 biological_processGO:0060137 maternal process involved in parturition IMP
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IMP
 biological_processGO:0061368 behavioral response to formalin induced pain IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Kalrntm1Ppen/Kalrn+
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

Allelic Composition: Kalrntm2.1Npl/Kalrn+
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0003506 acromegaly "excessive secretion of growth hormone resulting in progressive enlargement of the face, hands, feet, head, and thorax; organomegaly and impaired glucose homeostasis may ensue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0003838 abnormal milk ejection "impaired milk ejection reflex in response to suckling during lactation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36926]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kalrntm2.1Npl/Kalrn+
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

Allelic Composition: Kalrntm2.1Npl/Kalrn+
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm5Mal/Lattm5Mal
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Kalrntm2.1Npl/Kalrn+
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0012010 parturition failure "the process of labor and delivery in female animals does not initiate or complete" [MGI:csmith]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

 MP:0030567 abnormal I band morphology "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
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Allelic Composition: Kalrntm2.1Npl/Kalrntm2.1Npl
Genetic Background: B6.Cg-Kalrntm2.1Npl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / complex / reaction
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / complex / reaction
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction / complex






 

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