ENSMUSG00000031139


Mus musculus

Features
Gene ID: ENSMUSG00000031139
  
Biological name :Mcf2
  
Synonyms : Mcf2 / MCF.2 cell line derived transforming sequence
  
Possible biological names infered from orthology : P10911
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A6
Gene start: 60055956
Gene end: 60179089
  
Corresponding Affymetrix probe sets: 10604765 (MoGene1.0st)   1419021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154494
Ensembl peptide - ENSMUSP00000033478
Ensembl peptide - ENSMUSP00000067075
Ensembl peptide - ENSMUSP00000099070
NCBI entrez gene - 109904     See in Manteia.
MGI - MGI:96932
RefSeq - XM_017318350
RefSeq - XM_017318343
RefSeq - XM_017318344
RefSeq - XM_017318345
RefSeq - XM_017318346
RefSeq - XM_017318347
RefSeq - XM_017318348
RefSeq - XM_017318349
RefSeq - NM_001289730
RefSeq - NM_001289731
RefSeq - NM_133197
RefSeq - XM_006527743
RefSeq - XM_006527750
RefSeq Peptide - NP_001276659
RefSeq Peptide - NP_001276660
RefSeq Peptide - NP_573460
swissprot - A2AEU1
swissprot - A2AET8
swissprot - Q8BLE2
swissprot - Q8C067
Ensembl - ENSMUSG00000031139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcf2aENSDARG00000022895Danio rerio
 mcf2bENSDARG00000056603Danio rerio
 MCF2ENSGALG00000006562Gallus gallus
 MCF2ENSG00000101977Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcf2l / MCF.2 cell line derived transforming sequence like / O15068*ENSMUSG0000003144240
Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*ENSMUSG0000002226325
Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*ENSMUSG0000006175112
Plekhg1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSMUSG0000004062411
Arhgef25 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant 3, mRNA. / Q86VW2* / Rho guanine nucleotide exchange factor 25*ENSMUSG0000001946711
Q4VAC9 / Plekhg3 / Pleckstrin homology domain-containing family G member 3 / A1L390* / pleckstrin homology and RhoGEF domain containing G3*ENSMUSG0000005260911
Plekhg2 / pleckstrin homology and RhoGEF domain containing G2 / Q9H7P9*ENSMUSG0000003755210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Galk1tm1Stb/Galk1tm1Stb,Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction






 

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