ENSMUSG00000007815


Mus musculus

Features
Gene ID: ENSMUSG00000007815
  
Biological name :Rhoa
  
Synonyms : Q9QUI0 / ras homolog family member A / Rhoa
  
Possible biological names infered from orthology : P61586
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 108306129
Gene end: 108337934
  
Corresponding Affymetrix probe sets: 10515493 (MoGene1.0st)   10588893 (MoGene1.0st)   1437628_s_at (Mouse Genome 430 2.0 Array)   1443768_at (Mouse Genome 430 2.0 Array)   1450632_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141967
Ensembl peptide - ENSMUSP00000007959
Ensembl peptide - ENSMUSP00000141572
NCBI entrez gene - 11848     See in Manteia.
MGI - MGI:1096342
RefSeq - NM_001313961
RefSeq - NM_001313962
RefSeq - NM_016802
RefSeq Peptide - NP_001300891
RefSeq Peptide - NP_001300890
RefSeq Peptide - NP_058082
swissprot - Q4VAE6
swissprot - A0A0A6YWJ1
swissprot - Q9QUI0
swissprot - A0A0A6YXF6
Ensembl - ENSMUSG00000007815
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhoabENSDARG00000094673Danio rerio
 RHOAENSG00000067560Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*ENSMUSG0000000223392
Rhob / P62746 / ras homolog family member B / P62745*ENSMUSG0000005436484
4930544G11Rik / RIKEN cDNA 4930544G11 geneENSMUSG0000003646383
Rhod / P97348 / ras homolog family member D / O00212*ENSMUSG0000004184551
Rnd3 / P61588 / Rho-related GTP-binding protein RhoE / P61587* / Rho family GTPase 3*ENSMUSG0000001714450
Rnd2 / Q9QYM5 / Rho family GTPase 2 / P52198*ENSMUSG0000000131349
Rhof / Q8BYP3 / ras homolog family member F (in filopodia) / Q9HBH0* / ras homolog family member F, filopodia associated*ENSMUSG0000002944947
Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*ENSMUSG0000005485543


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0002363 alpha-beta T cell lineage commitment IMP
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction ISS
 biological_processGO:0007519 skeletal muscle tissue development IDA
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IMP
 biological_processGO:0010975 regulation of neuron projection development IDA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0021861 forebrain radial glial cell differentiation IMP
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030521 androgen receptor signaling pathway IDA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway IDA
 biological_processGO:0033688 regulation of osteoblast proliferation IMP
 biological_processGO:0034329 cell junction assembly IEA
 biological_processGO:0035385 Roundabout signaling pathway ISO
 biological_processGO:0036089 cleavage furrow formation IEA
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway IEA
 biological_processGO:0042476 odontogenesis IEP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0043366 beta selection IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046039 GTP metabolic process IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0060193 positive regulation of lipase activity ISO
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061383 trabecula morphogenesis IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071803 positive regulation of podosome assembly IGI
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:0090324 negative regulation of oxidative phosphorylation IMP
 biological_processGO:0097498 endothelial tube lumen extension ISO
 biological_processGO:1902766 skeletal muscle satellite cell migration ISS
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1903673 mitotic cleavage furrow formation ISO
 biological_processGO:1904695 positive regulation of vascular smooth muscle contraction IMP
 biological_processGO:1905244 regulation of modification of synaptic structure IEA
 biological_processGO:1990869 cellular response to chemokine IEA
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0051022 Rho GDP-dissociation inhibitor binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Axonal growth inhibition (RHOA activation)
Rho GTPase cycle
PI3K/AKT activation
Axonal growth stimulation
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
G beta:gamma signalling through PI3Kgamma
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
PCP/CE pathway
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate KTN1
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins
Ovarian tumor domain proteases
ERBB2 Regulates Cell Motility
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
SLIT2:ROBO1 increases RHOA activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009689 abnormal neural tube ventricular layer morphology "any structural anomaly of the layer of undifferentiated, proliferating cells that line the neural tube lumen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012091 increased midbrain size "greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Rhoatm1Yuyo/Rhoatm1Yuyo,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Ighmtm1.1Aak/Ighmtm1.1Aak
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction
 ENSMUSG00000049612 Omg / oligodendrocyte myelin glycoprotein / P23515*  / reaction / complex
 ENSMUSG00000040158 Q9DBG9 / Tax1bp3 / Tax1-binding protein 3 / O14907*  / complex / reaction
 ENSMUSG00000041498 Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*  / reaction / complex
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction
 ENSMUSG00000020458 Rtn4 / Q99P72 / reticulon 4 / Q9NQC3*  / complex / reaction
 ENSMUSG00000074657 Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*  / reaction / complex
 ENSMUSG00000038943 Prc1 / Q99K43 / protein regulator of cytokinesis 1 / O43663*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / reaction / complex
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction
 ENSMUSG00000024862 Klc2 / kinesin light chain 2 / Q9H0B6*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000034930 Rtkn / Q8C6B2 / Rhotekin / Q9BST9*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000036634 Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*  / reaction / complex
 ENSMUSG00000058230 Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*  / complex / reaction
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / reaction / complex
 ENSMUSG00000003872 B / Lin7b / O88951 / Q9HAP6* / lin-7 homolog B, crumbs cell polarity complex component*  / complex / reaction
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction
 ENSMUSG00000021262 Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000026259 Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*  / reaction
 ENSMUSG00000022832 Ropn1 / Q9ESG2 / Ropporin-1 / Q9HAT0* / ROPN1B* / Q9BZX4* / rhophilin associated tail protein 1* / rhophilin associated tail protein 1B*  / reaction / complex
 ENSMUSG00000022580 Rhpn1 / Q61085 / Rhophilin-1 / Q8TCX5* / rhophilin Rho GTPase binding protein 1*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000030494 Rhpn2 / Q8BWR8 / Rhophilin-2 / Q8IUC4* / rhophilin Rho GTPase binding protein 2*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction / complex
 ENSMUSG00000004591 Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000031139 Mcf2 / MCF.2 cell line derived transforming sequence / P10911*  / reaction
 ENSMUSG00000041977 Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*  / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000034574 Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*  / complex / reaction
 ENSMUSG00000059495 Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*  / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex






 

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