ENSMUSG00000020888


Mus musculus

Features
Gene ID: ENSMUSG00000020888
  
Biological name :Dvl2
  
Synonyms : Dvl2 / Q60838 / Segment polarity DVL-2
  
Possible biological names infered from orthology : dishevelled segment polarity protein 2 / O14641
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70000595
Gene end: 70012301
  
Corresponding Affymetrix probe sets: 10377704 (MoGene1.0st)   1417207_at (Mouse Genome 430 2.0 Array)   1448616_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019362
Ensembl peptide - ENSMUSP00000099635
Ensembl peptide - ENSMUSP00000140073
NCBI entrez gene - 13543     See in Manteia.
MGI - MGI:106613
RefSeq - NM_007888
RefSeq Peptide - NP_031914
swissprot - Q60838
Ensembl - ENSMUSG00000020888
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dvl2ENSDARG00000056184Danio rerio
 DVL2ENSG00000004975Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*ENSMUSG0000000323368
Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*ENSMUSG0000002907158
Dixdc1 / Dixin / Q80Y83 / Q155Q3* / DIX domain containing 1*ENSMUSG0000003206410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008341  Dishevelled-2
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007379 segment specification IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016055 Wnt signaling pathway NAS
 biological_processGO:0022007 convergent extension involved in neural plate elongation IMP
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0035282 segmentation IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0060029 convergent extension involved in organogenesis IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IGI
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0150012 positive regulation of neuron projection arborization IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton NAS
 cellular_componentGO:0005886 plasma membrane IGI
 cellular_componentGO:0005938 cell cortex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*/EGFP)4Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2/EGFP)2Awb/?
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2/EGFP)2Awb/?,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002632 vestigial tail "a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*/EGFP)4Awb/?
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Slc6a3tm2Mca/Slc6a3tm2Mca
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Dvl2tm1Awb/Dvl2+,Dvl3tm1Awb/Dvl3tm1Awb
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / reaction / complex
 ENSMUSG00000018293 Pfn1 / P62962 / profilin 1 / P07737*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000034574 Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*  / reaction / complex
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction / complex
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / reaction / complex
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex / reaction
 ENSMUSG00000012282 Wnt8a / Q64527 / wingless-type MMTV integration site family, member 8A / Q9H1J5* / Wnt family member 8A*  / complex
 ENSMUSG00000044548 Dact1 / Q8R4A3 / Dapper homolog 1 / Q9NYF0* / dishevelled binding antagonist of beta catenin 1*  / reaction / complex
 ENSMUSG00000036961 Wnt8b / wingless-type MMTV integration site family, member 8B / Q93098* / Wnt family member 8B*  / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / reaction / complex
 ENSMUSG00000050288 Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*  / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex / reaction
 ENSMUSG00000044674 Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*  / complex / reaction
 ENSMUSG00000026455 Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*  / complex / reaction
 ENSMUSG00000022997 Wnt1 / P04426 / wingless-type MMTV integration site family, member 1 / P04628* / Wnt family member 1*  / complex / reaction
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / complex
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / reaction / complex
 ENSMUSG00000024867 P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*  / reaction / complex
 ENSMUSG00000024387 Csnk2b / P67871 / Casein kinase II subunit beta / P67870* / casein kinase 2 beta*  / reaction
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000046707 O54833 / Csnk2a2 / Casein kinase II subunit alpha / P19784* / casein kinase 2 alpha 2*  / reaction
 ENSMUSG00000015957 Wnt11 / P48615 / wingless-type MMTV integration site family, member 11 / O96014* / Wnt family member 11*  / complex / reaction
 ENSMUSG00000041075 Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*  / complex / reaction
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction
 ENSMUSG00000101523 Q60737 / Gm10031 / predicted pseudogene 10031 / Q8NEV1* / P68400* / CSNK2A1* / CSNK2A3* / casein kinase 2 alpha 1* / casein kinase 2 alpha 3*  / reaction






 

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