ENSMUSG00000018363


Mus musculus

Features
Gene ID: ENSMUSG00000018363
  
Biological name :Smurf2
  
Synonyms : A2A5Z6 / E3 ubiquitin-protein ligase SMURF2 / Smurf2
  
Possible biological names infered from orthology : Q9HAU4 / SMAD specific E3 ubiquitin protein ligase 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106820066
Gene end: 106920715
  
Corresponding Affymetrix probe sets: 10392259 (MoGene1.0st)   10392261 (MoGene1.0st)   1429045_at (Mouse Genome 430 2.0 Array)   1429046_at (Mouse Genome 430 2.0 Array)   1454894_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129269
Ensembl peptide - ENSMUSP00000090177
Ensembl peptide - ENSMUSP00000099356
NCBI entrez gene - 66313     See in Manteia.
MGI - MGI:1913563
RefSeq - NM_025481
RefSeq - XM_006533936
RefSeq - XM_017314705
RefSeq Peptide - NP_079757
swissprot - A2A5Z6
Ensembl - ENSMUSG00000018363
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A9JRZ0ENSDARG00000038067Danio rerio
 SMURF2ENSGALG00000003566Gallus gallus
 Q9HAU4ENSG00000108854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878076
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*ENSMUSG0000002458941
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105840
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759840
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*ENSMUSG0000003193039
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*ENSMUSG0000003221638
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSMUSG0000002130136
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000004280735
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0030579 ubiquitin-dependent SMAD protein catabolic process ISO
 biological_processGO:1901165 positive regulation of trophoblast cell migration ISO
 cellular_componentGO:0000151 ubiquitin ligase complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Asymmetric localization of PCP proteins
Degradation of AXIN
Hedgehog on state
Ub-specific processing proteases
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Smotm1b(KOMP)Wtsi/Bay

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009309 small intestine adenocarcinoma "malignant neoplasm of epithelial cells in the small intestine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

Allelic Composition: Smurf1tm1Wran/Smurf1+,Smurf2tm1Wran/Smurf2tm1Wran
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Ptch1tm1Bjw/Ptch1tm1Bjw,Tcf21tm1(cre)Seq/Tcf21+
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Smurf2Gt(RRA098)Byg/Smurf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Vash2tm1Ysat/Vash2+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000021466 Ptch1 / Q61115 / Mus musculus patched 1 (Ptch1), transcript variant 2, mRNA. / Q13635* / patched 1*  / complex / reaction
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSMUSG00000000142 Axin2 / O88566 / Q9Y2T1*  / complex / reaction
 ENSMUSG00000005699 Pard6a / Q9Z101 / Partitioning defective 6 homolog alpha / Q9NPB6* / par-6 family cell polarity regulator alpha*  / reaction / complex
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSMUSG00000024182 Axin1 / O15169*  / reaction / complex






 

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