MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0000194 | hypercalcemia | "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0001566 | hyperphosphatemia | "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0002221 | abnormal lymph organ size | "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002490 | abnormal circulating immunoglobulin concentration | "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002495 | increased IgA | "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
|
MP:0002591 | decreased mean corpuscular volume | "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0002966 | decreased circulating alkaline phosphatase level | "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0003795 | abnormal bone structure | |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0004946 | abnormal regulatory T cell physiology | "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0004973 | increased regulatory T cell number | "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0005466 | abnormal T helper 2 physiology | "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions
" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0005562 | decreased mean corpuscular hemoglobin | "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0005568 | increased circulating total protein level | "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008092 | abnormal T-helper 2 cell differentiation | "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008568 | abnormal interleukin secretion | "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008660 | increased interleukin-10 secretion | "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008672 | increased interleukin-13 secretion | "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0008702 | increased interleukin-5 secretion | "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0010088 | decreased circulating fructosamine level | "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|
MP:0012188 | increased regulatory T cell apoptosis | "increase in the number of regulatory T cells undergoing programmed cell death" [MGI:csmith] |
Show
Allelic Composition: Itchtm1.1Alta/Itchtm1.1Alta,Foxp3tm4(YFP/icre)Ayr/Foxp3+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
MP:0013278 | decreased fasted circulating glucose level | "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza] |
Show
Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+ Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp
|