ENSMUSG00000031930


Mus musculus

Features
Gene ID: ENSMUSG00000031930
  
Biological name :Wwp2
  
Synonyms : Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / Wwp2
  
Possible biological names infered from orthology : O00308
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 107436365
Gene end: 107558595
  
Corresponding Affymetrix probe sets: 10575184 (MoGene1.0st)   10575211 (MoGene1.0st)   1438482_at (Mouse Genome 430 2.0 Array)   1442162_at (Mouse Genome 430 2.0 Array)   1448145_at (Mouse Genome 430 2.0 Array)   1448146_at (Mouse Genome 430 2.0 Array)   1456714_at (Mouse Genome 430 2.0 Array)   1457499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148813
Ensembl peptide - ENSMUSP00000132224
Ensembl peptide - ENSMUSP00000148365
Ensembl peptide - ENSMUSP00000148679
NCBI entrez gene - 66894     See in Manteia.
MGI - MGI:1914144
RefSeq - XM_006531301
RefSeq - NM_025830
RefSeq - XM_006531299
RefSeq Peptide - NP_080106
swissprot - A0A1D5RLH0
swissprot - Q3TXI7
swissprot - Q9DBH0
swissprot - I3RSH5
swissprot - A0A1D5RM92
Ensembl - ENSMUSG00000031930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wwp2ENSDARG00000061345Danio rerio
 WWP2ENSGALG00000000699Gallus gallus
 WWP2ENSG00000198373Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105863
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759856
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*ENSMUSG0000002458936
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*ENSMUSG0000001836334
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*ENSMUSG0000003221633
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000004280732
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSMUSG0000002130132
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878031
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006858 extracellular transport ISO
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032410 negative regulation of transporter activity ISO
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0051224 negative regulation of protein transport ISO
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IMP
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IGI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity
NOTCH3 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0008575 increased circulating interferon-beta level "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0030082 long lower incisors "increased length or overgrowth of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038146 Notch3 / Q61982 / Neurogenic locus notch homolog protein 3 Notch 3 extracellular truncation Notch 3 intracellular domain / Q9UM47*  / reaction / complex






 

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