ENSMUSG00000042807


Mus musculus

Features
Gene ID: ENSMUSG00000042807
  
Biological name :Hecw2
  
Synonyms : E3 ubiquitin-protein ligase HECW2 / Hecw2 / Q6I6G8
  
Possible biological names infered from orthology : HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 / Q9P2P5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.1
Gene start: 53806876
Gene end: 54195168
  
Corresponding Affymetrix probe sets: 10354598 (MoGene1.0st)   1455150_at (Mouse Genome 430 2.0 Array)   1458464_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084942
Ensembl peptide - ENSMUSP00000095348
Ensembl peptide - ENSMUSP00000113283
NCBI entrez gene - 329152     See in Manteia.
MGI - MGI:2685817
RefSeq - XM_017321236
RefSeq - NM_001001883
RefSeq - NM_172655
RefSeq - XM_006496068
RefSeq - XM_006496069
RefSeq - XM_011238537
RefSeq - XM_017321235
RefSeq - XM_006496066
RefSeq - XM_006496067
RefSeq Peptide - NP_001001883
RefSeq Peptide - NP_766243
swissprot - Q6I6G8
swissprot - A3KPB7
Ensembl - ENSMUSG00000042807
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hecw2aENSDARG00000062447Danio rerio
 hecw2bENSDARG00000063253Danio rerio
 LO018629.1ENSDARG00000113848Danio rerio
 HECW2ENSGALG00000007944Gallus gallus
 HECW2ENSG00000138411Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSMUSG0000002130157
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*ENSMUSG0000002458920
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*ENSMUSG0000003221619
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759819
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105819
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*ENSMUSG0000003193018
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878017
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*ENSMUSG0000001836317
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR032348  E3 ubiquitin-protein ligase HECW1/2, N-terminal
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0072686 mitotic spindle ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Hcrttm1.1(KOMP)Vlcg/Hcrttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Hcrttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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