ENSMUSG00000024589


Mus musculus

Features
Gene ID: ENSMUSG00000024589
  
Biological name :Nedd4l
  
Synonyms : Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : Q96PU5
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 64887705
Gene end: 65217831
  
Corresponding Affymetrix probe sets: 10456254 (MoGene1.0st)   1423269_a_at (Mouse Genome 430 2.0 Array)   1423270_at (Mouse Genome 430 2.0 Array)   1437400_at (Mouse Genome 430 2.0 Array)   1441305_at (Mouse Genome 430 2.0 Array)   1456044_at (Mouse Genome 430 2.0 Array)   1457374_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153052
Ensembl peptide - ENSMUSP00000132838
Ensembl peptide - ENSMUSP00000153107
Ensembl peptide - ENSMUSP00000153594
Ensembl peptide - ENSMUSP00000153537
Ensembl peptide - ENSMUSP00000153526
Ensembl peptide - ENSMUSP00000079280
NCBI entrez gene - 83814     See in Manteia.
MGI - MGI:1933754
RefSeq - XM_017318016
RefSeq - XM_006526377
RefSeq - XM_006526378
RefSeq - XM_006526379
RefSeq - XM_006526380
RefSeq - XM_006526382
RefSeq - XM_011247044
RefSeq - XM_011247047
RefSeq - XM_017318015
RefSeq - NM_001114386
RefSeq - NM_031881
RefSeq - XM_006526370
RefSeq - XM_006526371
RefSeq - XM_006526373
RefSeq - XM_006526374
RefSeq - XM_006526376
RefSeq Peptide - NP_114087
RefSeq Peptide - NP_001107858
swissprot - A0A286YDR6
swissprot - G3X9H8
swissprot - E9PXB7
swissprot - A0A286YCM8
swissprot - A0A286YCR1
swissprot - A0A286YDV4
Ensembl - ENSMUSG00000024589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nedd4lENSDARG00000060006Danio rerio
 ENSGALG00000034584Gallus gallus
 ENSGALG00000031355Gallus gallus
 NEDD4LENSG00000049759Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*ENSMUSG0000003221657
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105834
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759834
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*ENSMUSG0000003193032
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*ENSMUSG0000002130132
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000004280732
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*ENSMUSG0000001836331
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878029
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR024928  E3 ubiquitin-protein ligase, SMURF1 type
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901380 negative regulation of potassium ion transmembrane transport IEA
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IEA
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0019870 potassium channel inhibitor activity IEA
 molecular_functionGO:0019871 sodium channel inhibitor activity IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Stimuli-sensing channels
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Klf1tm1Tow/Klf1tm1Tow,Tg(HBB)#Tow/0
Genetic Background: Not Specified

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Klf1tm1Tow/Klf1tm1Tow,Tg(HBB)#Tow/0
Genetic Background: Not Specified

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010858 pulmonary epithelial necrosis "pathological cell death in the lung epithelium, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0010861 increased respiratory mucosa goblet cell number "greater number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0014206 decreased intestinal epithelial sodium ion transmembrane transport 
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Allelic Composition: Cisd2tm1Tfts/Cisd2tm1Tfts
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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