ENSMUSG00000021301


Mus musculus

Features
Gene ID: ENSMUSG00000021301
  
Biological name :Hecw1
  
Synonyms : E3 ubiquitin-protein ligase HECW1 / Hecw1 / Q8K4P8
  
Possible biological names infered from orthology : HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 / Q76N89
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 14226438
Gene end: 14523228
  
Corresponding Affymetrix probe sets: 10407841 (MoGene1.0st)   1440656_at (Mouse Genome 430 2.0 Array)   1441101_at (Mouse Genome 430 2.0 Array)   1456527_at (Mouse Genome 430 2.0 Array)   1460030_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152688
Ensembl peptide - ENSMUSP00000106145
Ensembl peptide - ENSMUSP00000152215
Ensembl peptide - ENSMUSP00000152279
Ensembl peptide - ENSMUSP00000152351
NCBI entrez gene - 94253     See in Manteia.
MGI - MGI:2444115
RefSeq - XM_017315651
RefSeq - XM_006516813
RefSeq - XM_006516814
RefSeq - XM_006516815
RefSeq - XM_006516816
RefSeq - XM_017315649
RefSeq - XM_017315650
RefSeq - NM_001081348
RefSeq - XM_006516809
RefSeq - XM_006516810
RefSeq - XM_006516811
RefSeq - XM_006516812
RefSeq Peptide - NP_001074817
swissprot - A0A1Y7VMF2
swissprot - A0A1Y7VJB7
swissprot - A0A1Y7VJ41
swissprot - A0A1Y7VJ05
swissprot - Q8K4P8
Ensembl - ENSMUSG00000021301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hecw1bENSDARG00000004291Danio rerio
 si:ch211-188f17.1ENSDARG00000100958Danio rerio
 HECW1ENSGALG00000037193Gallus gallus
 HECW1ENSG00000002746Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000004280756
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*ENSMUSG0000002458920
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*ENSMUSG0000002759819
Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*ENSMUSG0000004105819
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*ENSMUSG0000003193018
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*ENSMUSG0000003221618
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*ENSMUSG0000001836317
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*ENSMUSG0000003878016
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*ENSMUSG0000003882214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000569  HECT domain
 IPR001202  WW domain
 IPR032348  E3 ubiquitin-protein ligase HECW1/2, N-terminal
 IPR035892  C2 domain superfamily
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Degradation of DVL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex / reaction






 

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