Manteia

ENSMUSG00000041058

Mus musculus

Features

Gene ID:	ENSMUSG00000041058

Biological name :	Wwp1

Synonyms :	Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Wwp1

Possible biological names infered from orthology :	Q9H0M0

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	A3
Gene start:	19608303
Gene end:	19708993

Corresponding Affymetrix probe sets:	10511755 (MoGene1.0st) 1427097_at (Mouse Genome 430 2.0 Array) 1427098_at (Mouse Genome 430 2.0 Array) 1452299_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041627 Ensembl peptide - ENSMUSP00000103881 NCBI entrez gene - 107568 See in Manteia. MGI - MGI:1861728 RefSeq - XM_006537546 RefSeq - NM_001276292 RefSeq - NM_001355222 RefSeq - NM_177327 RefSeq - XM_006537545 RefSeq Peptide - NP_796301 RefSeq Peptide - NP_001263221 RefSeq Peptide - NP_001342151 swissprot - Q8BZZ3 Ensembl - ENSMUSG00000041058

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Itch / Q8C863 / E3 ubiquitin-protein ligase Itchy / Q96J02* / itchy E3 ubiquitin protein ligase*	ENSMUSG00000027598	60
Wwp2 / Q9DBH0 / WW domain containing E3 ubiquitin protein ligase 2 / O00308*	ENSMUSG00000031930	59
Nedd4l / neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase / Q96PU5*	ENSMUSG00000024589	36
Nedd4 / P46935 / neural precursor cell expressed, developmentally down-regulated 4 / P46934* / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase*	ENSMUSG00000032216	33
Hecw1 / Q8K4P8 / E3 ubiquitin-protein ligase HECW1 / Q76N89* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1*	ENSMUSG00000021301	33
A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*	ENSMUSG00000018363	33
Hecw2 / Q6I6G8 / E3 ubiquitin-protein ligase HECW2 / Q9P2P5* / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2*	ENSMUSG00000042807	32
Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*	ENSMUSG00000038780	31
Hace1 / Q3U0D9 / E3 ubiquitin-protein ligase HACE1 / Q8IYU2* / HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1*	ENSMUSG00000038822	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000008	C2 domain
IPR000569	HECT domain
IPR001202	WW domain
IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
IPR035892	C2 domain superfamily
IPR035983	HECT, E3 ligase catalytic domain
IPR036020	WW domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0016567	protein ubiquitination	TAS
biological_process	GO:0030217	T cell differentiation	TAS
biological_process	GO:0030324	lung development	TAS
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IDA

Pathways (from Reactome)

Pathway description

Downregulation of ERBB4 signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011710	increased osteoblast differentiation		Show Allelic Composition: Apc^Min/Apc⁺ Genetic Background: (AKR/J x C57BL/6J-Apc^Min)F1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000441	Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*	/ complex
ENSMUSG00000039153	Runx2 / Q08775 / runt related transcription factor 2 / Q13950*	/ complex / reaction
ENSMUSG00000025915	Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*	/ complex
ENSMUSG00000017868	Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*	/ complex
ENSMUSG00000031431	Q9Z2S7 / Tsc22d3 / TSC22 domain family protein 3 / Q99576* / TSC22 domain family member 3*	/ complex
ENSMUSG00000019970	Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*	/ complex
ENSMUSG00000028634	A2A884 / Hivep3 / Transcription factor HIVEP3 / Q5T1R4* / human immunodeficiency virus type I enhancer binding protein 3*	/ reaction / complex
ENSMUSG00000062209	Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr