ENSMUSG00000028634


Mus musculus

Features
Gene ID: ENSMUSG00000028634
  
Biological name :Hivep3
  
Synonyms : A2A884 / Hivep3 / Transcription factor HIVEP3
  
Possible biological names infered from orthology : human immunodeficiency virus type I enhancer binding protein 3 / Q5T1R4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 119733784
Gene end: 120138045
  
Corresponding Affymetrix probe sets: 10507675 (MoGene1.0st)   10507677 (MoGene1.0st)   1421150_at (Mouse Genome 430 2.0 Array)   1429134_at (Mouse Genome 430 2.0 Array)   1439660_at (Mouse Genome 430 2.0 Array)   1450132_at (Mouse Genome 430 2.0 Array)   1458802_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081330
Ensembl peptide - ENSMUSP00000101914
Ensembl peptide - ENSMUSP00000130249
NCBI entrez gene - 16656     See in Manteia.
MGI - MGI:106589
RefSeq - XM_011240453
RefSeq - XM_006502816
RefSeq - XM_006502817
RefSeq - XM_011240452
RefSeq - NM_010657
RefSeq - XM_006502815
RefSeq Peptide - NP_034787
swissprot - F7D7H6
swissprot - A2A884
Ensembl - ENSMUSG00000028634
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hivep3aENSDARG00000075928Danio rerio
 hivep3bENSDARG00000037154Danio rerio
 HIVEP3ENSGALG00000027365Gallus gallus
 HIVEP3ENSG00000127124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hivep2 / Q3UHF7 / Mus musculus human immunodeficiency virus type I enhancer binding protein 2 (Hivep2), transcript variant 2, mRNA. / P31629* / human immunodeficiency virus type I enhancer ...ENSMUSG0000001550130
Hivep1 / human immunodeficiency virus type I enhancer binding protein 1 / P15822*ENSMUSG0000002136629
Zfp831 / zinc finger protein 831 / Q5JPB2* / ZNF831*ENSMUSG0000005060012


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR034729  Zinc finger CCHC HIVEP-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Hrrh/Hrrh
Genetic Background: RHJ/LeJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrrh/Hrrh
Genetic Background: RHJ/LeJ

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Runx2tm1Mjo/Runx2+
Genetic Background: involves: C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hrrh/Hrrh
Genetic Background: RHJ/LeJ

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3+
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atf4tm1Tow/Atf4tm1Tow,Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: 129 * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hrrh/Hrrh
Genetic Background: RHJ/LeJ

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm3Glm/Hivep3+,Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129 * C57BL/6J * SJL * SJL/J

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm1Glm/Hivep3+
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Atf4tm1Tow/Atf4tm1Tow,Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: 129 * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hivep3tm2Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3+
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm2Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Atf4tm1Tow/Atf4tm1Tow,Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Nfatc1tm3Glm/Nfatc1tm3Glm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0012072 decreased susceptibility to osteoporosis "reduced likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility" [MGI:csmith]
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Allelic Composition: Hivep3tm3Glm/Hivep3tm3Glm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL/J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: C57BL/6

Allelic Composition: Atf4tm1Tow/Atf4tm1Tow,Hivep3tm1Glm/Hivep3tm1Glm
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / reaction / complex
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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