ENSMUSG00000015501


Mus musculus

Features
Gene ID: ENSMUSG00000015501
  
Biological name :Hivep2
  
Synonyms : Hivep2 / Mus musculus human immunodeficiency virus type I enhancer binding protein 2 (Hivep2), transcript variant 2, mRNA. / Q3UHF7
  
Possible biological names infered from orthology : human immunodeficiency virus type I enhancer binding protein 2 / P31629
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A2
Gene start: 13966075
Gene end: 14151374
  
Corresponding Affymetrix probe sets: 10361807 (MoGene1.0st)   1422018_at (Mouse Genome 430 2.0 Array)   1434904_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015645
Ensembl peptide - ENSMUSP00000140150
Ensembl peptide - ENSMUSP00000140180
Ensembl peptide - ENSMUSP00000140290
NCBI entrez gene - 15273     See in Manteia.
MGI - MGI:1338076
RefSeq - XM_017313809
RefSeq - NM_001358782
RefSeq - NM_001358783
RefSeq - NM_010437
RefSeq - XM_011243131
RefSeq - XM_011243132
RefSeq - XM_011243133
RefSeq - XM_017313807
RefSeq - XM_017313808
RefSeq - XM_006512556
RefSeq - XM_006512558
RefSeq - XM_006512559
RefSeq - XM_006512561
RefSeq - XM_011243129
RefSeq - XM_011243130
RefSeq Peptide - NP_001345711
RefSeq Peptide - NP_001345712
RefSeq Peptide - NP_034567
swissprot - Q3UHF7
swissprot - A0A087WQF9
Ensembl - ENSMUSG00000015501
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hivep2aENSDARG00000039987Danio rerio
 hivep2bENSDARG00000018773Danio rerio
 HIVEP2ENSGALG00000013795Gallus gallus
 HIVEP2ENSG00000010818Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A884 / Hivep3 / Transcription factor HIVEP3 / Q5T1R4* / human immunodeficiency virus type I enhancer binding protein 3*ENSMUSG0000002863429
Hivep1 / human immunodeficiency virus type I enhancer binding protein 1 / P15822*ENSMUSG0000002136627
Zfp831 / zinc finger protein 831 / Q5JPB2* / ZNF831*ENSMUSG0000005060010


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046872 metal ion binding TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hivep2tm1Sis/Hivep2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Hivep2tm1Sis/Hivep2tm1Sis
Genetic Background: C.Cg-Hivep2tm1Sis

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Hivep2tm1Sis/Hivep2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hivep2tm1Sis/Hivep2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Hivep2tm1Sis/Hivep2tm1Sis,Tg(DO11.10)10Dlo/?
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA

 MP:0013593 enlarged thymus cortex "increased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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