ENSMUSG00000039153


Mus musculus

Features
Gene ID: ENSMUSG00000039153
  
Biological name :Runx2
  
Synonyms : Q08775 / runt related transcription factor 2 / Runx2
  
Possible biological names infered from orthology : Q13950
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B3
Gene start: 44495987
Gene end: 44814797
  
Corresponding Affymetrix probe sets: 10451061 (MoGene1.0st)   1424704_at (Mouse Genome 430 2.0 Array)   1425389_a_at (Mouse Genome 430 2.0 Array)   1426034_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124918
Ensembl peptide - ENSMUSP00000124494
Ensembl peptide - ENSMUSP00000125196
Ensembl peptide - ENSMUSP00000125498
Ensembl peptide - ENSMUSP00000125284
Ensembl peptide - ENSMUSP00000109198
Ensembl peptide - ENSMUSP00000109201
Ensembl peptide - ENSMUSP00000109202
Ensembl peptide - ENSMUSP00000123707
Ensembl peptide - ENSMUSP00000123743
Ensembl peptide - ENSMUSP00000124199
Ensembl peptide - ENSMUSP00000124374
NCBI entrez gene - 12393     See in Manteia.
MGI - MGI:99829
RefSeq - XM_006523548
RefSeq - NM_001145920
RefSeq - NM_001146038
RefSeq - NM_001271627
RefSeq - NM_001271630
RefSeq - NM_001271631
RefSeq - NM_009820
RefSeq - XM_006523540
RefSeq - XM_006523541
RefSeq - XM_006523542
RefSeq - XM_006523543
RefSeq - XM_006523544
RefSeq - XM_006523545
RefSeq - XM_006523547
RefSeq Peptide - NP_001258559
RefSeq Peptide - NP_001258560
RefSeq Peptide - NP_033950
RefSeq Peptide - NP_001258556
RefSeq Peptide - NP_001139510
RefSeq Peptide - NP_001139392
swissprot - F8WHN7
swissprot - E0CZ12
swissprot - Q08775
swissprot - Q1PAG7
swissprot - E0CY45
swissprot - E9PUK7
swissprot - E0CZC6
swissprot - F6TRA6
swissprot - F7CN98
swissprot - F7CZB5
Ensembl - ENSMUSG00000039153
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx2aENSDARG00000040261Danio rerio
 RUNX2ENSGALG00000040276Gallus gallus
 RUNX2ENSG00000124813Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Runx1 / runt related transcription factor 1 / Q01196*ENSMUSG0000002295254
Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*ENSMUSG0000007069148


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR021216  Protein of unknown function DUF2722
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0002051 osteoblast fate commitment IGI
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0002076 osteoblast development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030217 T cell differentiation IDA
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IMP
 biological_processGO:0045667 regulation of osteoblast differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048863 stem cell differentiation IDA
 biological_processGO:0071773 cellular response to BMP stimulus IMP
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IGI
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000084 abnormal fontanelle morphology "structural defect in the membranous interval at the margins of cranial bones in neonates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Runx2tm1Kish/Runx2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Mjo/Runx2+,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

 MP:0000103 nasal bone hypoplasia "reduced cell number in the bone which forms the nasal bridge" [J:53370]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000118 arrest of tooth development "failure of differentiation of the teeth" [J:18378]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000128 growth retardation of molars "developmental delay of the growth of the molars" [J:17489]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Runx2tm1Ldq/Runx2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

 MP:0000138 absent vertebrae "missing bony segments of the spinal column" [J:35802]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000158 absent sternum "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000175 absent bone marrow cell "lack of cells that make up the core cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Ldq/Runx2+
Genetic Background: involves: C57BL/6J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Ejm/Pdpk1tm1Ejm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp2tm5(Notch1)Ysa/Mesp2tm5(Notch1)Ysa,Psen1tm1Shs/Psen1tm1Shs
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
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Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Mjo/Runx2+,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003074 absent metacarpal bones "missing the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Hkiy/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Hkiy/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Runx2tm1Mjo/Runx2+,Satb2tm1Rug/Satb2+
Genetic Background: Not Specified

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elanetm1Sds/Elanetm1Sds
Genetic Background: B6.129X1-Elanetm1Sds

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Mjo/Runx2+,Zfp521tm2Ngc/Zfp521+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Mjo/Runx2+,Tg(Eno2tTA)#Nes/0,Tg(tetO-Zfp521)#Rbar/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Hivep3tm1Glm/Hivep3tm1Glm,Runx2tm1Mjo/Runx2+
Genetic Background: involves: C57BL/6

 MP:0004338 small clavicle "reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Hkiy/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004339 absent clavicle "missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004341 absent scapula "missing either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004385 interparietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004420 parietal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004440 absent occipital bone "absence of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004441 small occipital bone "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: FlnbGt(XD076)Byg/FlnbGt(XD076)Byg,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004462 small basisphenoid bone "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

 MP:0004690 ischium bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004693 pubic bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004900 absent zygomatic arch "absence of the bony arch that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Runx2tm1Kish/Runx2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0005359 growth retardation of incisors "developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005473 decreased triiodothyronine level "less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aestm1Grid/Aestm1Grid,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0008156 decreased diameter of tibia "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Satb2tm1Rug/Satb2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sor+,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129X1/SvJ

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Gss/Runx2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Ldq/Runx2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Ldq/Runx2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009899 hyoid bone hypoplasia "underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009912 decreased hyoid bone size "reduced size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Zfp521tm2Ngc/Zfp521+
Genetic Background: Not Specified

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010864 abnormal enamel knot morphology "any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8808404]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Satb2tm1Rug/Satb2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx2tm1Mjo/Runx2+,Satb2tm1Rug/Satb2+
Genetic Background: Not Specified

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Runx2tm1Ldq/Runx2tm1Ldq
Genetic Background: involves: C57BL/6J

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kcne12J/Kcne12J
Genetic Background: C57BL/6J-Kcne12J/J

Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Runx2tm1Javed/Runx2tm1Javed,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Runx2tm1Gss/Runx2tm1Gss
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Hkiy/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013616 decreased volumetric bone mineral density "reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Runx1tm1.1Stkd/Runx1tm1.1Stkd,Runx2tm1Mjo/Runx2tm1Mjo,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: FlnbGt(XD076)Byg/FlnbGt(XD076)Byg,Runx2tm1Mjo/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Runx2tm1Mjo/Runx2tm1Mjo
Genetic Background: Not Specified

 MP:0030371 delayed sagittal suture closure "late onset of fusion of the sagittal suture of the skull" [MGI:anna]
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Allelic Composition: Runx2tm1Hkiy/Runx2tm1Hkiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030393 delayed fontanelle closure "late onset of closure of one or more of the membranous intervals at the margins of cranial bones" [MGI:anna]
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Allelic Composition: Runx2tm1Kish/Runx2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030438 increased osteoblast proliferation "increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
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Allelic Composition: Runx2tm1Jals/Runx2tm1Jals
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0030498 abnormal dental lamina morphology "any structural anomaly of the U-shaped stripe of thickened oral epithelium marking the future tooth row; the primary dental lamina is the earliest morphological structure of the tooth formed in the embryo; local thickenings of the dental lamina from which individual teeth are initiated are known as tooth placodes" [https://www.ncbi.nlm.nih.gov/books/NBK27071/]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0030507 abnormal dental papilla morphology "any structural anomaly of the condensation of ectomesenchymal cells called odontoblasts seen in histologic sections of a developing tooth; the dental papilla lies below a cellular aggregation known as the enamel organ and differentiates into the dentin and dental pulp" [https://en.wikipedia.org/wiki/Dental_papilla]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0030521 abnormal cervical loop morphology "any structural anomaly of the most cervical part of an enamel organ where the inner enamel epithelium and the outer enamel epithelium merge in a loop, thus delineating the end of the anatomic crown and the site where root formation begins; to form the root region, the cervical loop begins to grow deeper into the surrounding ectomesenchyme of the dental sac, elongating and moving away from the newly completed crown area to enclose more of the dental papilla, forming Hertwig s epithelial root sheath (HERS)" [https://books.google.com/books?isbn=0323290868, https://books.google.com/books?isbn=1455754099, https://www.stembook.org/node/551]
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Allelic Composition: F9tm2(F9)Dws/F9tm2(F9)Dws
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000567 Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*  / reaction / complex
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / reaction
 ENSMUSG00000026313 Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*  / complex / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000020525 Ppm1d / Q9QZ67 / Protein phosphatase 1D / O15297* / protein phosphatase, Mg2+/Mn2+ dependent 1D*  / reaction
 ENSMUSG00000019789 Hey2 / Q9QUS4 / Hairy/enhancer-of-split related with YRPW motif protein 2 / Q9UBP5* / hes related family bHLH transcription factor with YRPW motif 2*  / reaction / complex
 ENSMUSG00000022528 Hes1 / P35428 / Transcription factor HES-1 / Q14469* / hes family bHLH transcription factor 1*  / complex / reaction
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000038331 Satb2 / Q8VI24 / special AT-rich sequence binding protein 2 / Q9UPW6* / SATB homeobox 2*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000028086 Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*  / reaction / complex
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000035799 P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / reaction / complex
 ENSMUSG00000055435 Maf / P54843 / Transcription factor Maf / O75444* / MAF bZIP transcription factor*  / reaction / complex
 ENSMUSG00000060284 Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*  / reaction / complex
 ENSMUSG00000028634 A2A884 / Hivep3 / Transcription factor HIVEP3 / Q5T1R4* / human immunodeficiency virus type I enhancer binding protein 3*  / complex / reaction
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000024420 Q6KAS7 / Zfp521 / zinc finger protein 521 / Q96K83* / ZNF521*  / reaction / complex
 ENSMUSG00000039615 Stub1 / Q9WUD1 / STIP1 homology and U-Box containing protein 1 / Q9UNE7*  / reaction / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / complex / reaction
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / reaction / complex
 ENSMUSG00000038193 Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*  / reaction / complex
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / reaction / complex
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / reaction / complex
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000006456 Rbm14 / Q8C2Q3 / RNA-binding protein 14 / Q96PK6* / RNA binding motif protein 14*  / complex / reaction
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / complex






 

1 s.

 
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