ENSMUSG00000038193


Mus musculus

Features
Gene ID: ENSMUSG00000038193
  
Biological name :Hand2
  
Synonyms : Hand2 / Heart- and neural crest derivatives-expressed protein 2 / Q61039
  
Possible biological names infered from orthology : heart and neural crest derivatives expressed 2 / P61296
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B2
Gene start: 57320983
Gene end: 57324633
  
Corresponding Affymetrix probe sets: 10571860 (MoGene1.0st)   1422221_at (Mouse Genome 430 2.0 Array)   1436041_at (Mouse Genome 430 2.0 Array)   1443854_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044983
NCBI entrez gene - 15111     See in Manteia.
MGI - MGI:103580
RefSeq - NM_010402
RefSeq Peptide - NP_034532
swissprot - Q61039
Ensembl - ENSMUSG00000038193
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hand2ENSDARG00000008305Danio rerio
 HAND2ENSGALG00000030530Gallus gallus
 HAND2ENSG00000164107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733554
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*ENSMUSG0000003416124
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404122
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSMUSG0000002871722
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579922
Tcf15 / Q60756 / Transcription factor 15 / Q12870*ENSMUSG0000006807920
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780519
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*ENSMUSG0000004854015
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125115
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*ENSMUSG0000002841714


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003219 cardiac right ventricle formation IMP
 biological_processGO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
 biological_processGO:0003266 regulation of secondary heart field cardioblast proliferation IMP
 biological_processGO:0003278 apoptotic process involved in heart morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0010463 mesenchymal cell proliferation IMP
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034103 regulation of tissue remodeling IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042733 embryonic digit morphogenesis IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0043586 tongue development IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048485 sympathetic nervous system development IDA
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048935 peripheral nervous system neuron development IDA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060485 mesenchyme development IGI
 biological_processGO:0060536 cartilage morphogenesis IGI
 biological_processGO:0060982 coronary artery morphogenesis IMP
 biological_processGO:0061032 visceral serous pericardium development IMP
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IMP
 biological_processGO:0061325 cell proliferation involved in outflow tract morphogenesis IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1903929 primary palate development IMP
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000763 positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process IMP
 biological_processGO:2000764 positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0033613 activating transcription factor binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IGI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi,Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2+,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0000430 absent maxillary shelf "missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hand2tm1Cse/Hand2tm1Cse,Osr2tm2(cre)Jian/Osr2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: involves: 129/Sv

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrg1tm1Lwr/Nrg1tm1Lwr
Genetic Background: involves: 129/Sv

Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

 MP:0001026 abnormal adrenergic neuron morphology "malformation or absence of the neurons that release catecholamines at a synapse after an impulse" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insig1tm1.1Mbjg/Insig1tm1.1Mbjg,Insig2tm1Mbjg/Insig2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi,Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi,Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm1Brn/Brca2tm1Cam,Krastm4Tyj/Kras+,Trp53tm3Tyj/Trp53+,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1tm2Eno
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2+,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Mef2c-cre)#Blk/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1.2Zllr/Hand2tm1.2Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2tm1Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003228 abnormal sinus venosus "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0003649 reduced right ventricle 
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Mef2c-cre)#Blk/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003854 abnormal forelimb stylopod morphology 
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Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0003872 absent right ventricle "missing the lower right chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003874 absent branchial arches "missing the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2+,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand2tm1.2Zllr/Hand2tm1.2Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0004448 abnormal presphenoid bone morphology "any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004453 abnormal pterygoid bone morphology "any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm2.1(Hand1)Abfi/Hand1tm2.1(Hand1)Abfi,Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2tm1Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2tm1Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Cse/Hand2+,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008374 abnormal manubrium morphology "any structural abnormality in the handle of the malleus, which extends downward, inward, and backward from the neck of the malleus and is embedded throughout its length in the tympanic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0008382 gonial bone hypoplasia "underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Gli3Xt-J/Gli3Xt-J,Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129/Sv * BALB/cJ * C3H/HeJ * C57BL/6 * SJL

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1.1Zllr/Hand2tm1.2Zllr,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hand2tm1Cse/Hand2tm1Cse,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Eno/Hand2tm1Eno
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hand2tm1Cse/Hand2tm1Cse,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009893 cleft primary palate "congenital fissure of the tissues normally uniting to form the primary palate" [PMID:16680722]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009904 tongue hypoplasia "underdevelopment of the tongue, usually due to a deficiency in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0009914 abnormal hyoid bone lesser horn morphology "any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Osr2tm2(cre)Jian/Osr2+,Tg(CAG-Nog)1Ych/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(DBH-cre)1Cse/0
Genetic Background: involves: 129S1/Sv

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Cse/Hand2+,Tg(DBH-cre)1Cse/0
Genetic Background: involves: 129S1/Sv

 MP:0010355 abnormal first branchial arch artery morphology "any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Mef2c-cre)#Blk/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0010422 heart right ventricle hypoplasia "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Mef2c-cre)#Blk/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0010465 aberrant origin of the right subclavian artery "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0010580 decreased heart left ventricle size "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2tm1Eno,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand1tm1Eno/Hand1tm2Eno,Hand2tm1Eno/Hand2+,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno
Genetic Background: Not Specified

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr,Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1.1Majh/Hand2tm1.1Majh,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA * DBA/2

Allelic Composition: Hand2tm1Majh/Hand2tm1Majh
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: Hand2tm2Eno/Hand2tm2Eno
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(DBH-cre)1Cse/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hand2tm1Cse/Hand2+,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Mef2c-cre)#Blk/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hand2tm1Cse/Hand2+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

Allelic Composition: Hand2tm1Dsr/Hand2tm2.1Dsr,Tg(Tbx1-cre)#Dsr/0
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012511 dilated aortic sac "abnormally stretched or widened aperture of the luminal space of the endothelial lined dilation that is located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates" [MGI:anna]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hand2tm1.2Zllr/Hand2tm1.2Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013166 small forelimb buds "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Hand2tm1.2Zllr/Hand2tm1.2Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0030339 absent second pharyngeal arch artery "failure to develop or absence of the second pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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