ENSMUSG00000028717


Mus musculus

Features
Gene ID: ENSMUSG00000028717
  
Biological name :Tal1
  
Synonyms : P22091 / Tal1 / T cell acute lymphocytic leukemia 1
  
Possible biological names infered from orthology : P17542 / TAL bHLH transcription factor 1, erythroid differentiation factor
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D1
Gene start: 115056426
Gene end: 115071755
  
Corresponding Affymetrix probe sets: 10507131 (MoGene1.0st)   1449389_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030489
Ensembl peptide - ENSMUSP00000121437
Ensembl peptide - ENSMUSP00000124983
Ensembl peptide - ENSMUSP00000125202
NCBI entrez gene - 21349     See in Manteia.
MGI - MGI:98480
RefSeq - XM_006502916
RefSeq - NM_001287388
RefSeq - NM_011527
RefSeq - XM_006502910
RefSeq - XM_006502912
RefSeq - XM_006502913
RefSeq - XM_006502914
RefSeq - XM_006502915
RefSeq - XM_006502909
RefSeq Peptide - NP_001274317
RefSeq Peptide - NP_035657
swissprot - P22091
swissprot - Q3TZH7
swissprot - A2AD40
Ensembl - ENSMUSG00000028717
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tal1ENSDARG00000019930Danio rerio
 TAL1ENSGALG00000023296Gallus gallus
 TAL1ENSG00000162367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404131
Tcf15 / Q60756 / Transcription factor 15 / Q12870*ENSMUSG0000006807919
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*ENSMUSG0000002841718
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*ENSMUSG0000003416117
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*ENSMUSG0000004854016
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579916
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*ENSMUSG0000003819315
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125114
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780514
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733513


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030220 platelet formation IMP
 biological_processGO:0030221 basophil differentiation IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045637 regulation of myeloid cell differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045799 positive regulation of chromatin assembly or disassembly IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060018 astrocyte fate commitment IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060217 hemangioblast cell differentiation IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0060375 regulation of mast cell differentiation IMP
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IPI
 cellular_componentGO:0033193 Lsd1/2 complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjc1tm2.1Kni/Gjc1tm2.1Kni
Genetic Background: Not Specified

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Tal1tm2Sho/Tal1tm2Sho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kidins220tm1.2Fces/Kidins220tm1.2Fces
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tal1Hpt/Tal1+
Genetic Background: HPT/Le

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(tTA)Roos/?,Lhx3tm1(cre)Slp/Lhx3+,Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0009328 delayed heart looping "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tal1tm1Wehi/Tal1tm1Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Scarb1tm1Kri/Scarb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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