ENSDARG00000019930


Danio rerio

Features
Gene ID: ENSDARG00000019930
  
Biological name :tal1
  
Synonyms : O93507 / tal1 / T-cell acute lymphocytic leukemia 1
  
Possible biological names infered from orthology : P17542 / P22091 / TAL bHLH transcription factor 1, erythroid differentiation factor
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 16535575
Gene end: 16545330
  
Corresponding Affymetrix probe sets: Dr.1458.1.S1_at (Zebrafish Array)   NM_213237_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000077498
NCBI entrez gene - 30766     See in Manteia.
RefSeq - NM_213237
RefSeq Peptide - NP_998402
swissprot - O93507
ZFIN ID - ZDB-GENE-980526-501
Ensembl - ENSDARG00000019930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TAL1ENSGALG00000023296Gallus gallus
 TAL1ENSG00000162367Homo sapiens
 Tal1ENSMUSG00000028717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CABZ01066694.1 / LYL1* / P12980* / P27792* / Protein lyl-1 * / LYL1, basic helix-loop-helix family member*ENSDARG0000011017825
tal2 / T-cell acute lymphocytic leukemia 2 / Q16559* / Q62282* / TAL bHLH transcription factor 2*ENSDARG0000004204118
tcf15 / transcription factor 15ENSDARG0000006754417
scxa / scleraxis bHLH transcription factor a / SCX* / Q7RTU7* / Q64124* / scleraxis* / scleraxis bHLH transcription factor*ENSDARG0000003569516
twist3ENSDARG0000001964616
scxb / scleraxis bHLH transcription factor b / SCX* / Q7RTU7* / Q64124* / scleraxis* / scleraxis bHLH transcription factor*ENSDARG0000001163515
twist1b / twist family bHLH transcription factor 1b / Q8WVJ9* / TWIST1* / TWIST2* / P26687* / Q15672* / twist family bHLH transcription factor 1* / twist family bHLH transcription factor 2*...ENSDARG0000007601015
twist1a / twist family bHLH transcription factor 1a / Q8WVJ9* / TWIST1* / TWIST2* / P26687* / Q15672* / twist family bHLH transcription factor 1* / twist family bHLH transcription factor 2*...ENSDARG0000003040215
twist2 / Q15672* / Q8WVJ9* / TWIST1* / P26687* / twist family bHLH transcription factor 2* / twist family bHLH transcription factor 1* / twist basic helix-loop-helix transcription factor 1*...ENSDARG0000007826615
si:ch211-246m6.4ENSDARG0000004285714
nhlh2 / nescient helix loop helix 2 / NHLH1* / Q02575* / Q64221* / Q02576* / Q02577* / nescient helix-loop-helix 1*ENSDARG0000002549514
hand2 / heart and neural crest derivatives expressed 2 / P61296* / Q61039* / Heart- and neural crest derivatives-expressed protein 2 *ENSDARG0000000830513


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0003160 endocardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030099 myeloid cell differentiation IEP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IMP
 biological_processGO:0048368 lateral mesoderm development IMP
 biological_processGO:0048823 nucleate erythrocyte development IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0060214 endocardium formation IMP
 biological_processGO:0060215 primitive hemopoiesis IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060217 hemangioblast cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood nucleate erythrocyte absent , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta alkaline phosphatase activity decreased occurrence , abnormal
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 ZFA:0000028 heart primordium heart primordium presumptive endocardium aplastic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000471 atrium atrium lacks all parts of type ventricular endocardium , abnormal
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 ZFA:0001079 blood vasculature blood vasculature lacks parts or has fewer parts of type blood vessel , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
intersegmental vessel malformed , abnormal
intersegmental vessel absent , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus decreased amount , abnormal
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 ZFA:0001320 endocardium endocardium decreased anterior-posterior diameter , abnormal
endocardium aggregated , abnormal
endocardium cardiac muscle cell differentiation process quality , abnormal
endocardium cell-cell junction mislocalised , abnormal
endocardium cell-cell junction organization decreased process quality , abnormal
endocardium endothelial cell obtuse , abnormal
endocardium endothelial cell aggregated , abnormal
endocardium morphology , abnormal
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 ZFA:0001615 ventricular endocardium ventricular endocardium aggregated , abnormal
ventricular endocardium epithelium aplastic , abnormal
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 ZFA:0001724 presumptive endocardium presumptive endocardium morphogenesis of an epithelial sheet decreased process quality , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature decreased size , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta lacks all parts of type hematopoietic stem cell , abnormal
ventral wall of dorsal aorta endothelial cell apoptotic , abnormal
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 ZFA:0005037 post-vent vasculature post-vent vasculature decreased size , abnormal
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 ZFA:0005040 posterior lateral mesoderm posterior lateral mesoderm morphology , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell apoptotic , abnormal
hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte immature , abnormal
nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009324 myeloid cell myeloid cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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