ENSG00000162367


Homo sapiens

Features
Gene ID: ENSG00000162367
  
Biological name :TAL1
  
Synonyms : P17542 / TAL1 / TAL bHLH transcription factor 1, erythroid differentiation factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p33
Gene start: 47216290
Gene end: 47232220
  
Corresponding Affymetrix probe sets: 1561651_s_at (Human Genome U133 Plus 2.0 Array)   206283_s_at (Human Genome U133 Plus 2.0 Array)   216925_s_at (Human Genome U133 Plus 2.0 Array)   216928_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360951
Ensembl peptide - ENSP00000294339
NCBI entrez gene - 6886     See in Manteia.
OMIM - 187040
RefSeq - NM_001290405
RefSeq - NM_003189
RefSeq - XM_017002191
RefSeq - NM_001287347
RefSeq - NM_001290403
RefSeq - NM_001290404
RefSeq - XM_005271160
RefSeq - XM_017002187
RefSeq - XM_017002188
RefSeq - XM_017002189
RefSeq - XM_017002190
RefSeq Peptide - NP_001274276
RefSeq Peptide - NP_001277332
RefSeq Peptide - NP_001277333
RefSeq Peptide - NP_001277334
RefSeq Peptide - NP_003180
swissprot - P17542
Ensembl - ENSG00000162367
  
Related genetic diseases (OMIM): 613065 - Leukemia, T-cell acute lymphocytic, somatic, 613065

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tal1ENSDARG00000019930Danio rerio
 TAL1ENSGALG00000023296Gallus gallus
 Tal1ENSMUSG00000028717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LYL1 / P12980 / LYL1, basic helix-loop-helix family memberENSG0000010490332
TAL2 / Q16559 / TAL bHLH transcription factor 2ENSG0000018605118
TCF15 / Q12870 / transcription factor 15ENSG0000012587817
SCX / Q7RTU7 / scleraxis bHLH transcription factorENSG0000026042817
Q15672 / TWIST1 / twist family bHLH transcription factor 1ENSG0000012269115
NHLH2 / Q02577 / nescient helix-loop-helix 2ENSG0000017755115
NHLH1 / Q02575 / nescient helix-loop-helix 1ENSG0000017178614
HAND2 / P61296 / heart and neural crest derivatives expressed 2ENSG0000016410714
Q8WVJ9 / TWIST2 / twist family bHLH transcription factor 2ENSG0000023360814
HAND1 / O96004 / heart and neural crest derivatives expressed 1ENSG0000011319613


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030221 basophil differentiation IEP
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045799 positive regulation of chromatin assembly or disassembly IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048699 generation of neurons IEA
 biological_processGO:0051781 positive regulation of cell division IMP
 biological_processGO:0060018 astrocyte fate commitment IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 biological_processGO:0060217 hemangioblast cell differentiation IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0060375 regulation of mast cell differentiation IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 cellular_componentGO:0000118 histone deacetylase complex IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033193 Lsd1/2 complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0006721 Acute lymphatic leukemia "A form of acute leukemia characterized by excess lympoblasts." [HPO:curators]
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 HP:0010982 Polygenic inheritance "A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci." [HPO:probinson, ISBN:978-0192628961]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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