ENSGALG00000023296


Gallus gallus

Features
Gene ID: ENSGALG00000023296
  
Biological name :TAL1
  
Synonyms : TAL1 / T-cell acute lymphocytic leukemia protein 1 homolog
  
Possible biological names infered from orthology : P17542 / P22091 / TAL bHLH transcription factor 1, erythroid differentiation factor / T cell acute lymphocytic leukemia 1
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 21980018
Gene end: 21986222
  
Corresponding Affymetrix probe sets: Gga.6758.1.S1_at (Chicken Array)   Gga.6758.1.S1_s_at (Chicken Array)   Gga.6758.2.A1_at (Chicken Array)   Gga.752.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057207
Ensembl peptide - ENSGALP00000041680
NCBI entrez gene - 396298     See in Manteia.
RefSeq - NM_205352
RefSeq Peptide - NP_990683
swissprot - R4GHW3
swissprot - A0A1D5PW76
Ensembl - ENSGALG00000023296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tal1ENSDARG00000019930Danio rerio
 TAL1ENSG00000162367Homo sapiens
 Tal1ENSMUSG00000028717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TAL2 / TAL bHLH transcription factor 2 / Q16559* / Q62282* / T cell acute lymphocytic leukemia 2*ENSGALG0000002311417
TCF15 / transcription factor 15 / Q12870* / Q60756*ENSGALG0000002627617
TWIST2ENSGALG0000000427415
TWIST3ENSGALG0000004022015
HAND2 / heart and neural crest derivatives expressed 2 / P61296* / Q61039* / Heart- and neural crest derivatives-expressed protein 2 *ENSGALG0000003053015
TWIST1 / twist family bHLH transcription factor 1 / P26687* / Q15672* / twist basic helix-loop-helix transcription factor 1*ENSGALG0000004164015
NHLH1 / helix-loop-helix protein 1 / NHLH2* / Q02575* / Q02576* / Q02577* / Q64221* / nescient helix-loop-helix 2* / nescient helix-loop-helix 1*ENSGALG0000002581714
HAND1 / heart- and neural crest derivatives-expressed protein 1 / O96004* / Q64279* / heart and neural crest derivatives expressed 1*ENSGALG0000003510413


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0021527 spinal cord association neuron differentiation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030221 basophil differentiation IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043249 erythrocyte maturation IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045799 positive regulation of chromatin assembly or disassembly IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048699 generation of neurons IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060018 astrocyte fate commitment IEA
 biological_processGO:0060216 definitive hemopoiesis IEA
 biological_processGO:0060217 hemangioblast cell differentiation IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0060375 regulation of mast cell differentiation IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033193 Lsd1/2 complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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