ENSGALG00000030530


Gallus gallus

Features
Gene ID: ENSGALG00000030530
  
Biological name :HAND2
  
Synonyms : HAND2 / heart and neural crest derivatives expressed 2
  
Possible biological names infered from orthology : Heart- and neural crest derivatives-expressed protein 2 / P61296 / Q61039
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 43676569
Gene end: 43677709
  
Corresponding Affymetrix probe sets: GgaAffx.21783.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045960
Ensembl peptide - ENSGALP00000049911
NCBI entrez gene - 395813     See in Manteia.
RefSeq - NM_204966
RefSeq Peptide - NP_990297
swissprot - A0A1D5PAZ4
swissprot - A0A1D5NZZ0
Ensembl - ENSGALG00000030530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hand2ENSDARG00000008305Danio rerio
 HAND2ENSG00000164107Homo sapiens
 Hand2ENSMUSG00000038193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HAND1 / heart- and neural crest derivatives-expressed protein 1 / O96004* / Q64279* / heart and neural crest derivatives expressed 1*ENSGALG0000003510450
TWIST1 / twist family bHLH transcription factor 1 / P26687* / Q15672* / twist basic helix-loop-helix transcription factor 1*ENSGALG0000004164021
TAL1 / T-cell acute lymphocytic leukemia protein 1 homolog / P22091* / P17542* / T cell acute lymphocytic leukemia 1* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSGALG0000002329621
TWIST3ENSGALG0000004022019
TWIST2ENSGALG0000000427419
TCF15 / transcription factor 15 / Q12870* / Q60756*ENSGALG0000002627619
NHLH1 / helix-loop-helix protein 1 / NHLH2* / Q02575* / Q02576* / Q02577* / Q64221* / nescient helix-loop-helix 2* / nescient helix-loop-helix 1*ENSGALG0000002581714
TAL2 / TAL bHLH transcription factor 2 / Q16559* / Q62282* / T cell acute lymphocytic leukemia 2*ENSGALG0000002311414


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003219 cardiac right ventricle formation IEA
 biological_processGO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
 biological_processGO:0003266 regulation of secondary heart field cardioblast proliferation IEA
 biological_processGO:0003278 apoptotic process involved in heart morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0010463 mesenchymal cell proliferation IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0034103 regulation of tissue remodeling IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043586 tongue development IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048935 peripheral nervous system neuron development IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060485 mesenchyme development IEA
 biological_processGO:0060536 cartilage morphogenesis IEA
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0061032 visceral serous pericardium development IEA
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IEA
 biological_processGO:0061325 cell proliferation involved in outflow tract morphogenesis IEA
 biological_processGO:0061371 determination of heart left/right asymmetry IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1903929 primary palate development IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000763 positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process IEA
 biological_processGO:2000764 positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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