ENSGALG00000041640


Gallus gallus

Features
Gene ID: ENSGALG00000041640
  
Biological name :TWIST1
  
Synonyms : TWIST1 / twist family bHLH transcription factor 1
  
Possible biological names infered from orthology : P26687 / Q15672 / twist basic helix-loop-helix transcription factor 1
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 29649182
Gene end: 29651300
  
Corresponding Affymetrix probe sets: Gga.3973.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060441
Ensembl peptide - ENSGALP00000045092
NCBI entrez gene - 395491     See in Manteia.
RefSeq - NM_204739
RefSeq Peptide - NP_990070
swissprot - Q9PVG4
swissprot - A0A1L1RNS3
Ensembl - ENSGALG00000041640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q15672ENSG00000122691Homo sapiens
 P26687ENSMUSG00000035799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TWIST2ENSGALG0000000427469
TWIST3ENSGALG0000004022059
TCF15 / transcription factor 15 / Q12870* / Q60756*ENSGALG0000002627626
TAL1 / T-cell acute lymphocytic leukemia protein 1 homolog / P22091* / P17542* / T cell acute lymphocytic leukemia 1* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSGALG0000002329625
HAND2 / heart and neural crest derivatives expressed 2 / P61296* / Q61039* / Heart- and neural crest derivatives-expressed protein 2 *ENSGALG0000003053024
HAND1 / heart- and neural crest derivatives-expressed protein 1 / O96004* / Q64279* / heart and neural crest derivatives expressed 1*ENSGALG0000003510421
TAL2 / TAL bHLH transcription factor 2 / Q16559* / Q62282* / T cell acute lymphocytic leukemia 2*ENSGALG0000002311418
NHLH1 / helix-loop-helix protein 1 / NHLH2* / Q02575* / Q02576* / Q02577* / Q64221* / nescient helix-loop-helix 2* / nescient helix-loop-helix 1*ENSGALG0000002581717


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR015789  Twist-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0003180 aortic valve morphogenesis IEA
 biological_processGO:0003183 mitral valve morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033128 negative regulation of histone phosphorylation IEA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035137 hindlimb morphogenesis IEA
 biological_processGO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0044092 negative regulation of molecular function IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0060421 positive regulation of heart growth IMP
 biological_processGO:0060900 embryonic camera-type eye formation IEA
 biological_processGO:0060973 cell migration involved in heart development IMP
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:1902725 negative regulation of satellite cell differentiation IMP
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IEA
 biological_processGO:2000147 positive regulation of cell motility IEA
 biological_processGO:2000276 negative regulation of oxidative phosphorylation uncoupler activity IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 biological_processGO:2000780 negative regulation of double-strand break repair IEA
 biological_processGO:2000793 cell proliferation involved in heart valve development IEA
 biological_processGO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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