Manteia

ENSDARG00000008305

Danio rerio

Features

Gene ID:	ENSDARG00000008305

Biological name :	hand2

Synonyms :	hand2 / heart and neural crest derivatives expressed 2

Possible biological names infered from orthology :	Heart- and neural crest derivatives-expressed protein 2 / P61296 / Q61039

Species:	Danio rerio

Chr. number:	1
Strand:	-1
Band:
Gene start:	38193147
Gene end:	38195012

Corresponding Affymetrix probe sets:	Dr.8328.1.S1_at (Zebrafish Array) NM_131626_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000022921 NCBI entrez gene - 58150 See in Manteia. RefSeq - NM_131626 RefSeq Peptide - NP_571701 swissprot - A2BDM6 ZFIN ID - ZDB-GENE-000511-1 Ensembl - ENSDARG00000008305

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HAND2	ENSGALG00000030530	Gallus gallus
HAND2	ENSG00000164107	Homo sapiens
Hand2	ENSMUSG00000038193	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
scxb / scleraxis bHLH transcription factor b / SCX* / Q7RTU7* / Q64124* / scleraxis* / scleraxis bHLH transcription factor*	ENSDARG00000011635	22
tcf15 / transcription factor 15	ENSDARG00000067544	22
twist1a / twist family bHLH transcription factor 1a / Q8WVJ9* / TWIST1* / TWIST2* / P26687* / Q15672* / twist family bHLH transcription factor 1* / twist family bHLH transcription factor 2*...	ENSDARG00000030402	21
twist1b / twist family bHLH transcription factor 1b / Q8WVJ9* / TWIST1* / TWIST2* / P26687* / Q15672* / twist family bHLH transcription factor 1* / twist family bHLH transcription factor 2*...	ENSDARG00000076010	21
tal1 / O93507 / T-cell acute lymphocytic leukemia 1 / P22091* / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*	ENSDARG00000019930	21
twist2 / Q15672* / Q8WVJ9* / TWIST1* / P26687* / twist family bHLH transcription factor 2* / twist family bHLH transcription factor 1* / twist basic helix-loop-helix transcription factor 1*...	ENSDARG00000078266	21
scxa / scleraxis bHLH transcription factor a / SCX* / Q7RTU7* / Q64124* / scleraxis* / scleraxis bHLH transcription factor*	ENSDARG00000035695	20
twist3	ENSDARG00000019646	20
si:ch211-246m6.4	ENSDARG00000042857	20
CABZ01066694.1 / LYL1* / P12980* / P27792* / Protein lyl-1 * / LYL1, basic helix-loop-helix family member*	ENSDARG00000110178	17
nhlh2 / nescient helix loop helix 2 / NHLH1* / Q02575* / Q64221* / Q02576* / Q02577* / nescient helix-loop-helix 1*	ENSDARG00000025495	15
tal2 / T-cell acute lymphocytic leukemia 2 / Q16559* / Q62282* / TAL bHLH transcription factor 2*	ENSDARG00000042041	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000009	cardiac ventricle	cardiac ventricle shape , abnormal cardiac ventricle decreased size , abnormal cardiac ventricle structure , abnormal	Show
ZFA:0000028	heart primordium	heart primordium unfused from heart primordium , abnormal heart primordium myocardial precursor decreased amount , abnormal	Show
ZFA:0000054	pericardium	pericardium edematous , abnormal	Show
ZFA:0000095	pharyngeal arch 3-7 skeleton	pharyngeal arch 3-7 skeleton aplastic , abnormal pharyngeal arch 3-7 skeleton quality , abnormal	Show
ZFA:0000108	fin	fin quality , abnormal	Show
ZFA:0000114	heart	heart morphology , abnormal heart quality , abnormal heart malformed , abnormal	Show
ZFA:0000115	heart rudiment	heart rudiment bifurcated , abnormal	Show
ZFA:0000121	lateral plate mesoderm	lateral plate mesoderm decreased width , abnormal	Show
ZFA:0000123	liver	liver duplicated , abnormal	Show
ZFA:0000140	pancreas	pancreas duplicated , abnormal	Show
ZFA:0000141	pectoral fin bud	pectoral fin bud decreased size , abnormal	Show
ZFA:0000191	dentary	dentary shape , abnormal	Show
ZFA:0000236	mandibular muscle	mandibular muscle wholly dorsalized , abnormal	Show
ZFA:0000257	pectoral fin cartilage	pectoral fin cartilage absent , abnormal	Show
ZFA:0000292	surface structure	surface structure quality , abnormal	Show
ZFA:0000360	heart tube	heart tube absent , abnormal heart tube aplastic , abnormal	Show
ZFA:0000422	retroarticular	retroarticular distended , abnormal	Show
ZFA:0000471	atrium	atrium shape , abnormal atrium decreased size , abnormal	Show
ZFA:0001072	thyroid follicle	thyroid follicle aplastic , abnormal thyroid follicle decreased amount , abnormal	Show
ZFA:0001081	thyroid primordium	thyroid primordium decreased size , abnormal thyroid primordium aplastic , abnormal	Show
ZFA:0001155	enteric nervous system	enteric nervous system neuron decreased amount , abnormal	Show
ZFA:0001161	pectoral fin	pectoral fin quality , abnormal	Show
ZFA:0001205	Meckel s cartilage	Meckels cartilage aplastic , abnormal Meckels cartilage decreased size , abnormal Meckels cartilage decreased length , abnormal	Show
ZFA:0001306	pharyngeal arch	pharyngeal arch joint absent , abnormal	Show
ZFA:0001338	intestine	intestine smooth muscle cell morphology , abnormal intestine neuron decreased amount , abnormal	Show
ZFA:0001400	ceratohyal cartilage	ceratohyal cartilage aplastic , abnormal	Show
ZFA:0001439	anatomical system	anatomical system quality , abnormal	Show
ZFA:0001453	pectoral fin field	pectoral fin field decreased size , abnormal	Show
ZFA:0001510	basihyal cartilage	basihyal cartilage aplastic , abnormal	Show
ZFA:0001511	interhyal cartilage	interhyal cartilage absent , abnormal	Show
ZFA:0001572	superior cervical ganglion	superior cervical ganglion physical object quality , abnormal	Show
ZFA:0001611	pharyngeal arch 2	pharyngeal arch 2 joint increased distribution , abnormal	Show
ZFA:0001612	pharyngeal arch 1	pharyngeal arch 1 mesenchyme physical object quality , abnormal pharyngeal arch 1 joint absent , abnormal pharyngeal arch 1 mesenchyme increased area , abnormal	Show
ZFA:0005057	epicardium	epicardium aplastic , abnormal	Show
ZFA:0009181	vascular associated smooth muscle cell	vascular associated smooth muscle cell absent , abnormal	Show
ZFA:0009234	cardiac muscle myoblast	cardiac muscle myoblast decreased amount , abnormal	Show
ZFA:0009288	primordial germ cell	primordial germ cell dispersed , abnormal primordial germ cell mislocalised anteriorly , abnormal	Show
ZFA:0009316	cardiac muscle cell	cardiac muscle cell organization quality , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr