ENSG00000177551


Homo sapiens

Features
Gene ID: ENSG00000177551
  
Biological name :NHLH2
  
Synonyms : nescient helix-loop-helix 2 / NHLH2 / Q02577
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.1
Gene start: 115836377
Gene end: 115843917
  
Corresponding Affymetrix probe sets: 214497_s_at (Human Genome U133 Plus 2.0 Array)   215228_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000322087
Ensembl peptide - ENSP00000405062
Ensembl peptide - ENSP00000358519
NCBI entrez gene - 4808     See in Manteia.
OMIM - 162361
RefSeq - NM_005599
RefSeq - XM_017001370
RefSeq - NM_001111061
RefSeq Peptide - NP_001104531
RefSeq Peptide - NP_005590
swissprot - A0A024R0I7
swissprot - Q02577
swissprot - A6PVY9
Ensembl - ENSG00000177551
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nhlh2ENSDARG00000025495Danio rerio
 NHLH1ENSGALG00000025817Gallus gallus
 Nhlh2ENSMUSG00000048540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NHLH1 / Q02575 / nescient helix-loop-helix 1ENSG0000017178666
TAL1 / P17542 / TAL bHLH transcription factor 1, erythroid differentiation factorENSG0000016236738
LYL1 / P12980 / LYL1, basic helix-loop-helix family memberENSG0000010490335
SCX / Q7RTU7 / scleraxis bHLH transcription factorENSG0000026042831
Q15672 / TWIST1 / twist family bHLH transcription factor 1ENSG0000012269128
Q8WVJ9 / TWIST2 / twist family bHLH transcription factor 2ENSG0000023360827
TCF15 / Q12870 / transcription factor 15ENSG0000012587826
HAND1 / O96004 / heart and neural crest derivatives expressed 1ENSG0000011319625
TAL2 / Q16559 / TAL bHLH transcription factor 2ENSG0000018605124
HAND2 / P61296 / heart and neural crest derivatives expressed 2ENSG0000016410724


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007617 mating behavior IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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