ENSMUSG00000048540


Mus musculus

Features
Gene ID: ENSMUSG00000048540
  
Biological name :Nhlh2
  
Synonyms : nescient helix loop helix 2 / Nhlh2 / Q64221
  
Possible biological names infered from orthology : Q02577
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 102010076
Gene end: 102015492
  
Corresponding Affymetrix probe sets: 10494795 (MoGene1.0st)   1436888_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064355
Ensembl peptide - ENSMUSP00000142746
Ensembl peptide - ENSMUSP00000143362
NCBI entrez gene - 18072     See in Manteia.
MGI - MGI:97324
RefSeq - NM_178777
RefSeq - XM_006501112
RefSeq Peptide - NP_848892
swissprot - Q64221
Ensembl - ENSMUSG00000048540
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nhlh2ENSDARG00000025495Danio rerio
 NHLH1ENSGALG00000025817Gallus gallus
 NHLH2ENSG00000177551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125166
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSMUSG0000002871738
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404133
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*ENSMUSG0000003416132
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579928
Tcf15 / Q60756 / Transcription factor 15 / Q12870*ENSMUSG0000006807927
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780527
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733526
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*ENSMUSG0000003819324
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*ENSMUSG0000002841724


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007617 mating behavior IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042698 ovulation cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001376 abnormal mating receptivity "deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ngfrtm1b(EUCOMM)Wtsi/Ngfrtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ngfrtm1b(EUCOMM)Wtsi/H

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bfsp1tm1Pgf/Bfsp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0002716 small preputial glands "reduced size of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:82312]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004156 abnormal QT variability "anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx20tm1Sev/Tbx20tm1.1Sev,Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss

 MP:0005188 small penis "in comparison to the norm, reduced size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0005189 abnormal anogenital distance "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006110 ventricular fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006277 abnormal parasympathetic nervous system physiology "anomaly in the function of the craniosacral portion of the autonomic nervous system" [Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:78031]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Nhlh1tm1Thbr/Nhlh1tm1Thbr,Nhlh2tm1Thbr/Nhlh2tm1Thbr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0009018 short estrus "decrease in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0009732 ventricular premature beat "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
Show

Allelic Composition: Nhlh2tm1Thbr/Nhlh2tm1Thbr,Tg(Pomc-EGFP)1Low/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(Gnrh1-cre)1Dlc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
Show

Allelic Composition: Nhlh2tm2Thbr/Nhlh2tm2Thbr,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr