ENSMUSG00000028417


Mus musculus

Features
Gene ID: ENSMUSG00000028417
  
Biological name :Tal2
  
Synonyms : Q62282 / Tal2 / T cell acute lymphocytic leukemia 2
  
Possible biological names infered from orthology : Q16559 / TAL bHLH transcription factor 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B2
Gene start: 53779705
Gene end: 53788712
  
Corresponding Affymetrix probe sets: 10505059 (MoGene1.0st)   1450517_at (Mouse Genome 430 2.0 Array)   1460309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030124
NCBI entrez gene - 21350     See in Manteia.
MGI - MGI:99540
RefSeq - NM_009317
RefSeq Peptide - NP_033343
swissprot - Q2TB09
swissprot - Q62282
Ensembl - ENSMUSG00000028417
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tal2ENSDARG00000042041Danio rerio
 TAL2ENSGALG00000023114Gallus gallus
 TAL2ENSG00000186051Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSMUSG0000002871754
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404147
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*ENSMUSG0000003416138
Tcf15 / Q60756 / Transcription factor 15 / Q12870*ENSMUSG0000006807935
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579933
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780533
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*ENSMUSG0000004854031
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125131
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733528
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*ENSMUSG0000003819328


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0021794 thalamus development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000776 abnormal inferior colliculus "dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0002892 reduced size of superior colliculus "decreased size of the paired superior eminence of the mesencephalic tectum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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