Manteia

ENSMUSG00000034041

Mus musculus

Features

Gene ID:	ENSMUSG00000034041

Biological name :	Lyl1

Synonyms :	Lyl1 / P27792 / Protein lyl-1

Possible biological names infered from orthology :	LYL1, basic helix-loop-helix family member / P12980

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	C2
Gene start:	84701457
Gene end:	84704715

Corresponding Affymetrix probe sets:	10573419 (MoGene1.0st) 1419120_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046010 NCBI entrez gene - 17095 See in Manteia. MGI - MGI:96891 RefSeq - XM_006530745 RefSeq - NM_008535 RefSeq - XM_006530744 RefSeq Peptide - NP_032561 swissprot - P27792 Ensembl - ENSMUSG00000034041

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CABZ01066694.1	ENSDARG00000110178	Danio rerio
LYL1	ENSG00000104903	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*	ENSMUSG00000028717	37
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*	ENSMUSG00000028417	18
Tcf15 / Q60756 / Transcription factor 15 / Q12870*	ENSMUSG00000068079	18
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*	ENSMUSG00000034161	18
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*	ENSMUSG00000038193	17
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*	ENSMUSG00000037335	16
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*	ENSMUSG00000048540	16
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*	ENSMUSG00000035799	16
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*	ENSMUSG00000007805	15
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*	ENSMUSG00000051251	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001955	blood vessel maturation	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	ISO
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0030183	B cell differentiation	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0060216	definitive hemopoiesis	IMP
cellular_component	GO:0005634	nucleus	IBA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IBA
molecular_function	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	IBA
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001802	arrested B cell development	"inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lyl1^tm1Mago/Lyl1^tm1Mago Genetic Background: B6.129S7-Lyl1^tm1Mago
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nefm^tm1Jpj/Nefm^tm1Jpj Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Lyl1^tm1Mago/Lyl1^tm1Mago Genetic Background: B6.129S7-Lyl1^tm1Mago

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr