ENSMUSG00000068079


Mus musculus

Features
Gene ID: ENSMUSG00000068079
  
Biological name :Tcf15
  
Synonyms : Q60756 / Tcf15 / Transcription factor 15
  
Possible biological names infered from orthology : Q12870
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 152143561
Gene end: 152149097
  
Corresponding Affymetrix probe sets: 10477069 (MoGene1.0st)   1449592_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086511
NCBI entrez gene - 21407     See in Manteia.
MGI - MGI:104664
RefSeq - NM_009328
RefSeq - XM_006499100
RefSeq Peptide - NP_033354
swissprot - Q60756
Ensembl - ENSMUSG00000068079
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TCF15ENSGALG00000026276Gallus gallus
 TCF15ENSG00000125878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*ENSMUSG0000003416156
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSMUSG0000002871731
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404126
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579925
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780525
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733524
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*ENSMUSG0000003819322
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125119
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*ENSMUSG0000002841719
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*ENSMUSG0000004854018


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042755 eating behavior IMP
 biological_processGO:0043583 ear development IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0048644 muscle organ morphogenesis IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0050884 neuromuscular process controlling posture IMP
 biological_processGO:0060231 mesenchymal to epithelial transition IMP
 biological_processGO:1903053 regulation of extracellular matrix organization IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000078 abnormal supraoccipital bone morphology "malformed upper part of the occipital bone" [J:61509]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000080 abnormal exoccipital bone morphology "malformed lateral part of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006295 absent sclerotome "absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae" [J:60303, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008149 abnormal rib-vertebral column attachment "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012248 absent dermatome "absence of the mesoderm that is derived from the somite that is fated to become the dermis" [MGI:anna]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0012249 absent myotome "absence of the mesoderm that is derived from the somite that is fated to become the musculature" [MGI:anna]
Show

Allelic Composition: Tal1tm2Wehi/Tal1tm2Wehi
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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