ENSMUSG00000034161


Mus musculus

Features
Gene ID: ENSMUSG00000034161
  
Biological name :Scx
  
Synonyms : Q64124 / scleraxis / Scx
  
Possible biological names infered from orthology : Q7RTU7 / scleraxis bHLH transcription factor
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 76457452
Gene end: 76459458
  
Corresponding Affymetrix probe sets: 10424905 (MoGene1.0st)   1428983_at (Mouse Genome 430 2.0 Array)   1456291_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043668
NCBI entrez gene - 20289     See in Manteia.
MGI - MGI:102934
RefSeq - NM_198885
RefSeq Peptide - NP_942588
swissprot - Q53ZC3
swissprot - Q64124
Ensembl - ENSMUSG00000034161
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scxaENSDARG00000035695Danio rerio
 scxbENSDARG00000011635Danio rerio
 SCXENSG00000260428Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf15 / Q60756 / Transcription factor 15 / Q12870*ENSMUSG0000006807953
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*ENSMUSG0000002871728
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*ENSMUSG0000003819325
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*ENSMUSG0000003579925
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*ENSMUSG0000003404124
Hand1 / Q64279 / Heart- and neural crest derivatives-expressed protein 1 / O96004* / heart and neural crest derivatives expressed 1*ENSMUSG0000003733523
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*ENSMUSG0000000780522
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*ENSMUSG0000004854021
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*ENSMUSG0000002841720
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*ENSMUSG0000005125120


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0003188 heart valve formation IMP
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035989 tendon development IMP
 biological_processGO:0035990 tendon cell differentiation IMP
 biological_processGO:0035992 tendon formation IMP
 biological_processGO:0035993 deltoid tuberosity development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048706 embryonic skeletal system development IEP
 biological_processGO:0051216 cartilage development NAS
 biological_processGO:0060008 Sertoli cell differentiation ISS
 biological_processGO:0060325 face morphogenesis IEP
 biological_processGO:0061035 regulation of cartilage development IMP
 biological_processGO:0061036 positive regulation of cartilage development IMP
 biological_processGO:0061056 sclerotome development IEP
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 biological_processGO:0071773 cellular response to BMP stimulus IEP
 biological_processGO:2000543 positive regulation of gastrulation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Scxtm1.1Stzr/Scxtm1.1Stzr,Tg(Scx-GFP)1Stzr/0
Genetic Background: Not Specified

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Scxtm1.1Stzr/Scxtm1.1Stzr,Tg(Scx-GFP)1Stzr/0
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003097 abnormal tendon stiffness "altered ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Mao
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk,Tg(Col2a1-PTHLH)2Ecw/0,Tg(PTHLH)7Wmp/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Scxtm1.1Stzr/Scxtm1.1Stzr,Tg(Scx-GFP)1Stzr/0
Genetic Background: Not Specified

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Mao
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Mao
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Aph1btm1Bdes/Aph1btm1Bdes,Aph1ctm1.1Bdes/Aph1ctm1.1Bdes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr