Manteia

ENSMUSG00000037335

Mus musculus

Features

Gene ID:	ENSMUSG00000037335

Biological name :	Hand1

Synonyms :	Hand1 / Heart- and neural crest derivatives-expressed protein 1 / Q64279

Possible biological names infered from orthology :	heart and neural crest derivatives expressed 1 / O96004

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B1.3
Gene start:	57828705
Gene end:	57832818

Corresponding Affymetrix probe sets:	10386110 (MoGene1.0st) 1417525_at (Mouse Genome 430 2.0 Array) 1448750_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000046999 Ensembl peptide - ENSMUSP00000104473 Ensembl peptide - ENSMUSP00000124951 NCBI entrez gene - 15110 See in Manteia. MGI - MGI:103577 RefSeq - NM_008213 RefSeq Peptide - NP_032239 swissprot - Q5SQG0 swissprot - Q5SQG1 swissprot - Q64279 Ensembl - ENSMUSG00000037335

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HAND1	ENSGALG00000035104	Gallus gallus
HAND1	ENSG00000113196	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hand2 / Q61039 / Heart- and neural crest derivatives-expressed protein 2 / P61296* / heart and neural crest derivatives expressed 2*	ENSMUSG00000038193	55
Scx / Q64124 / scleraxis / Q7RTU7* / scleraxis bHLH transcription factor*	ENSMUSG00000034161	22
Tcf15 / Q60756 / Transcription factor 15 / Q12870*	ENSMUSG00000068079	21
Lyl1 / P27792 / Protein lyl-1 / P12980* / LYL1, basic helix-loop-helix family member*	ENSMUSG00000034041	20
Tal1 / P22091 / T cell acute lymphocytic leukemia 1 / P17542* / TAL bHLH transcription factor 1, erythroid differentiation factor*	ENSMUSG00000028717	20
P26687 / Twist1 / twist basic helix-loop-helix transcription factor 1 / Q15672* / twist family bHLH transcription factor 1*	ENSMUSG00000035799	19
Twist2 / twist basic helix-loop-helix transcription factor 2 / Q8WVJ9* / twist family bHLH transcription factor 2*	ENSMUSG00000007805	18
Nhlh2 / Q64221 / nescient helix loop helix 2 / Q02577*	ENSMUSG00000048540	16
Nhlh1 / Q02576 / nescient helix loop helix 1 / Q02575*	ENSMUSG00000051251	16
Tal2 / Q62282 / T cell acute lymphocytic leukemia 2 / Q16559* / TAL bHLH transcription factor 2*	ENSMUSG00000028417	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0001525	angiogenesis	IMP
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001707	mesoderm formation	IMP
biological_process	GO:0001709	cell fate determination	NAS
biological_process	GO:0001824	blastocyst development	IEA
biological_process	GO:0001829	trophectodermal cell differentiation	IEA
biological_process	GO:0001947	heart looping	IMP
biological_process	GO:0003007	heart morphogenesis	NAS
biological_process	GO:0003144	embryonic heart tube formation	IMP
biological_process	GO:0003218	cardiac left ventricle formation	ISO
biological_process	GO:0003219	cardiac right ventricle formation	ISO
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	ISO
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0030154	cell differentiation	IGI
biological_process	GO:0035050	embryonic heart tube development	IMP
biological_process	GO:0042475	odontogenesis of dentin-containing tooth	IGI
biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	ISO
biological_process	GO:0060411	cardiac septum morphogenesis	ISO
biological_process	GO:0060485	mesenchyme development	IGI
biological_process	GO:0060536	cartilage morphogenesis	IGI
biological_process	GO:0060707	trophoblast giant cell differentiation	IMP
biological_process	GO:0061371	determination of heart left/right asymmetry	IMP
biological_process	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005737	cytoplasm	ISO
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	ISO
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003713	transcription coactivator activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	ISO
molecular_function	GO:0019899	enzyme binding	IPI
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042803	protein homodimerization activity	IPI
molecular_function	GO:0043425	bHLH transcription factor binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IGI
molecular_function	GO:0044212	transcription regulatory region DNA binding	ISO
molecular_function	GO:0046982	protein heterodimerization activity	IPI
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000040	absent middle ear ossicles	"missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0000103	nasal bone hypoplasia	"reduced cell number in the bone which forms the nasal bridge" [J:53370]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0000108	midline facial cleft	"incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6
MP:0000270	abnormal heart tube morphology	"malformed embryonic heart " [J:37888]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6
MP:0000273	overriding aorta	"congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6
MP:0000279	ventricular hypoplasia	"reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi},Hand2^tm1Dsr/Hand2^tm1Dsr Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0000295	poorly developed ventricular trabeculae	"retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2⁺,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000455	abnormal maxilla morphology	"malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0000762	abnormal tongue morphology	"anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0000847	abnormal metencephalon morphology	"any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000934	abnormal telencephalon development	"malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0001680	abnormal mesoderm development	"failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi},Hand2^tm1Dsr/Hand2^tm1Dsr Genetic Background: involves: 129S7/SvEvBrd
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0001711	abnormal placenta		Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001712	abnormal placental development	"malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Hand1^tm2.1Jcc/Hand1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001713	reduced trophoblast cell number	"fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001716	abnormal placental labyrinth	"malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0001719	absent vitelline blood vessels	"missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001722	pale yolk sac	"bloodless yolk sac" [J:62571]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001724	abnormal extraembryonic endoderm formation	"malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]	Show Allelic Composition: Gh^Sma1/Gh⁺ Genetic Background: C3HeB/FeJ-Gh^Sma1
MP:0001727	abnormal embryo implantation	"failure or reduced ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Runx1^tm1Buch/Runx1^tm1Buch Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0002086	abnormal extraembryonic tissue morphology	"structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002127	abnormal cardiovascular system morphology	"abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi},Hand2^tm1Dsr/Hand2^tm1Dsr Genetic Background: involves: 129S7/SvEvBrd
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1Jcc/Hand1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Hand1^tm2Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^{tm1.1(EGFP/cre)Abfi}/Hand1⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor
MP:0002189	abnormal myocardial trabeculae morphology	"malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0002584	small ectoplacental cone		Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2⁺,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0002745	abnormal atrioventricular valve morphology	"malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0002824	abnormal chorioallantoic fusion	"abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002836	abnormal chorion	"malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0003105	abnormal heart atrium morphology	"structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2^tm1Eno,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0003235	abnormal alisphenoid bone morphology	"malformation in either of the broad curved winglike expanses on each side of the sphenoid bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93183, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0003567	abnormal cardiomyocyte proliferation	"anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6
MP:0003843	abnormal sagittal suture morphology	"malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2⁺,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2os1^em1Eno/Hand2os1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004076	abnormal vitelline vascular remodelling	"anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gh^Sma1/Gh⁺ Genetic Background: C3HeB/FeJ-Gh^Sma1
MP:0004251	failure of looping morphogenesis	"failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004377	small frontal bone	"reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004385	interparietal bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004455	pterygoid bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, in the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004461	basisphenoid bone hypoplasia	"underdevelopment or reduced size, usually due to reduced cell number, in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004470	small nasal bone	"reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004473	absent nasal bone	"absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004556	enlarged allantois	"increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0004592	small mandible	"reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004726	abnormal nasal capsule morphology	"any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,Tg(Mpz-cre)94Imeg/0 Genetic Background: Not Specified
MP:0004869	frontal bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the forehead and roof of the eye orbit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004871	premaxilla hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, in the anterior and interior portion of the maxilla" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004872	absent nasal septum	"absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004899	absent squamosal bone	"absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004915	abnormal Reichert s cartilage	"any structural abnormality of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0005029	abnormal amnion	"malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005033	abnormal trophoblast cells	"anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005221	abnormal rostral-caudal axis patterning	"anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi},Hand2^tm1Dsr/Hand2^tm1Dsr Genetic Background: involves: 129S7/SvEvBrd
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2^tm1Eno,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2^tm1Eno/Hand2^tm1Eno Genetic Background: Not Specified
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2^tm1Eno,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2^tm1Eno/Hand2^tm1Eno Genetic Background: Not Specified
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0006113	abnormal heart septum morphology	"abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified
MP:0006372	impaired placental function	"reduction in the ability of the placenta to supply nutrients or remove waste" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified
MP:0008959	abnormal spongiotrophoblast cell morphology	"any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009653	abnormal palate development	"abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,Tg(Mpz-cre)94Imeg/0 Genetic Background: Not Specified
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0009887	abnormal palatal shelf fusion at midline	"any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0009895	decreased palatine shelf size	"reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0009897	decreased maxillary shelf size	"reduced size of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0010395	abnormal branchial arch development	"abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0010432	common ventricle	"the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2os1^em1Eno/Hand2os1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010498	abnormal interventricular septum muscular part morphology	"any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0010580	decreased heart left ventricle size	"less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0010831	partial lethality	"the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010940	abnormal maxillary prominence morphology		Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hand1^tm1Cse/Hand1^tm1Cse Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster) Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2os1^em1Eno/Hand2os1⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Gh^Sma1/Gh⁺ Genetic Background: C3HeB/FeJ-Gh^Sma1
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2^tm1Eno,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Hand1^tm1Eno/Hand1^tm2Eno,Hand2^tm1Eno/Hand2⁺,Tg(Nkx2-5-cre)9Eno/0 Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) Allelic Composition: Hand1^tm1Eno/Hand1⁺,Hand2^tm1Eno/Hand2^tm1Eno Genetic Background: Not Specified Allelic Composition: Hand1^{tm1.1(EGFP/cre)Abfi}/Hand1^{tm1.1(EGFP/cre)Abfi} Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor Allelic Composition: Hand1^{tm2(Hand1)Abfi}/Hand1^{tm2(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Hand1^tm1(tTA)Prri/Hand1⁺,Tg(tetO-Hand1)1Prri/0 Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Hand1^{tm2.1(Hand1)Abfi}/Hand1^{tm2.1(Hand1)Abfi} Genetic Background: Not Specified Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011203	abnormal parietal yolk sac morphology	"any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]	Show Allelic Composition: Hand1^tm1Jcc/Hand1^tm1Jcc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0011205	excessive folding of visceral yolk sac	"the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]	Show Allelic Composition: Esx1^tm1Bhr/Y Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013933	short Meckel s cartilage		Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0030112	zygomatic bone hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the quadrilateral bone that forms the prominence of the cheek" [MGI:anna]	Show Allelic Composition: Hand1^tm3Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0030122	temporal bone squamous part hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 Allelic Composition: Hand1^tm4Abfi/Hand1⁺,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: C3H * C57BL/6
MP:0030124	middle ear ossicle hypoplasia	"underdevelopment or reduced size of the three bones of the middle ear, usually due to reduced cell number" [MGI:anna]	Show Allelic Composition: Hand1^tm2Eno/Hand1^tm4Abfi,E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺ Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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