ENSG00000104903


Homo sapiens

Features
Gene ID: ENSG00000104903
  
Biological name :LYL1
  
Synonyms : LYL1 / LYL1, basic helix-loop-helix family member / P12980
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.13
Gene start: 13099033
Gene end: 13103161
  
Corresponding Affymetrix probe sets: 210044_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264824
Ensembl peptide - ENSP00000468122
NCBI entrez gene - 4066     See in Manteia.
OMIM - 151440
RefSeq - XM_017026817
RefSeq - NM_005583
RefSeq - XM_005259912
RefSeq - XM_017026816
RefSeq Peptide - NP_005574
swissprot - K7ER61
swissprot - P12980
Ensembl - ENSG00000104903
  
Related genetic diseases (OMIM): 151440 - Leukemia, T-cell acute lymphoblastoid

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01066694.1ENSDARG00000110178Danio rerio
 Lyl1ENSMUSG00000034041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TAL1 / P17542 / TAL bHLH transcription factor 1, erythroid differentiation factorENSG0000016236738
SCX / Q7RTU7 / scleraxis bHLH transcription factorENSG0000026042819
TAL2 / Q16559 / TAL bHLH transcription factor 2ENSG0000018605119
TCF15 / Q12870 / transcription factor 15ENSG0000012587818
NHLH1 / Q02575 / nescient helix-loop-helix 1ENSG0000017178617
HAND2 / P61296 / heart and neural crest derivatives expressed 2ENSG0000016410717
Q15672 / TWIST1 / twist family bHLH transcription factor 1ENSG0000012269117
NHLH2 / Q02577 / nescient helix-loop-helix 2ENSG0000017755117
Q8WVJ9 / TWIST2 / twist family bHLH transcription factor 2ENSG0000023360816
HAND1 / O96004 / heart and neural crest derivatives expressed 1ENSG0000011319616


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001955 blood vessel maturation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0060216 definitive hemopoiesis IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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