ENSMUSG00000024420


Mus musculus

Features
Gene ID: ENSMUSG00000024420
  
Biological name :Zfp521
  
Synonyms : Q6KAS7 / Zfp521 / zinc finger protein 521
  
Possible biological names infered from orthology : Q96K83 / ZNF521
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 13687013
Gene end: 13972733
  
Corresponding Affymetrix probe sets: 10457587 (MoGene1.0st)   1439909_at (Mouse Genome 430 2.0 Array)   1451332_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025288
NCBI entrez gene - 225207     See in Manteia.
MGI - MGI:95459
RefSeq - XM_011246894
RefSeq - NM_145492
RefSeq - XM_006525819
RefSeq - XM_006525820
RefSeq Peptide - NP_663467
swissprot - Q6KAS7
Ensembl - ENSMUSG00000024420
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znf521ENSDARG00000086825Danio rerio
 ZNF521ENSGALG00000015112Gallus gallus
 Q96K83ENSG00000198795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80TS5 / Zfp423 / zinc finger protein 423 / Q2M1K9* / ZNF423*ENSMUSG0000004533362


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048663 neuron fate commitment IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1l1tm1a(EUCOMM)Hmgu/Npc1l1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003795 abnormal bone structure 
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Runx2tm1Mjo/Runx2+
Genetic Background: Not Specified

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0008938 decreased pituitary gland weight "reduction in the average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0009393 abnormal resting posture "atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0009911 increased hyoid bone size "greater size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

 MP:0009912 decreased hyoid bone size "reduced size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Runx2tm1Mjo/Runx2+,Zfp521tm2Ngc/Zfp521+
Genetic Background: Not Specified

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0012204 abnormal neuronal stem cell physiology "any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors" [CL:0000047]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

 MP:0013308 decreased adrenal gland weight "reduced average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [MGI:anna]
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Allelic Composition: Zfp521tm1Nokh/Zfp521tm1Nokh
Genetic Background: B6J.Cg-Zfp521tm1Nokh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / complex / reaction






 

1 s.

 
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