Manteia

ENSMUSG00000045333

Mus musculus

Features

Gene ID:	ENSMUSG00000045333

Biological name :	Zfp423

Synonyms :	Q80TS5 / Zfp423 / zinc finger protein 423

Possible biological names infered from orthology :	Q2M1K9 / ZNF423

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	C3
Gene start:	87661810
Gene end:	87959595

Corresponding Affymetrix probe sets:	10580473 (MoGene1.0st) 1419380_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000052379 Ensembl peptide - ENSMUSP00000105282 Ensembl peptide - ENSMUSP00000129724 Ensembl peptide - ENSMUSP00000134103 Ensembl peptide - ENSMUSP00000134575 NCBI entrez gene - 94187 See in Manteia. MGI - MGI:1891217 RefSeq - XM_011248560 RefSeq - XM_006531539 RefSeq - XM_011248561 RefSeq - NM_001310520 RefSeq - NM_033327 RefSeq - XM_017313033 RefSeq Peptide - NP_201584 RefSeq Peptide - NP_001297449 swissprot - Q80TS5 swissprot - G3UYI9 swissprot - G3UW89 swissprot - G3UZP1 Ensembl - ENSMUSG00000045333

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
A1L1R6	ENSDARG00000059707	Danio rerio
znf423	ENSDARG00000095732	Danio rerio
ZNF423	ENSGALG00000003891	Gallus gallus
Q2M1K9	ENSG00000102935	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q6KAS7 / Zfp521 / zinc finger protein 521 / Q96K83* / ZNF521*	ENSMUSG00000024420	62

Protein motifs (from Interpro)

Interpro ID	Name
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007219	Notch signaling pathway	IDA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030513	positive regulation of BMP signaling pathway	IDA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0000820	abnormal choroid plexus morphology	"malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000825	dilated lateral ventricles	"increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000829	dilated fourth ventricle	"enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0000846	abnormal medulla oblongata	"anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0000850	absent cerebellum	"missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000851	cerebellum hypoplasia	"reduced cell number in the cerebellum" [MGI:CLS, J:45302]	Show Allelic Composition: Zfp423^nur12/Zfp423^Gt(XH542)Byg Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0000854	abnormal cerebellum development	"malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000856	abnormal cerebellar plate morphology	"malformed embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium" [J:45302]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000864	abnormal vermis	"malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0000865	absent vermis	"missing narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000866	vermis hypoplasia	"reduced cell number in the vermis" [J:61509]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0000885	ectopic Purkinje cell	"Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Bcl2^tm1Mpin/Bcl2^tm1Mpin,Tg(SFTPC-RAF1-BxB)1Urr/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Zfp423^tm1.1Ngc/Zfp423^tm1.1Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^nur12/Zfp423^Gt(XH542)Byg Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Zfp423^tm1.1Ngc/Zfp423^tm1.1Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^tm1.1Ngc/Zfp423^tm1.1Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^tm1.1Ngc/Zfp423^tm1.1Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hnf1b^tm2Mya/Hnf1b^tm2Mya Genetic Background: involves: 129S2/SvPas Allelic Composition: Zfp423^tm1.1Ngc/Zfp423^tm1.1Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0002196	acallosal	"absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H
MP:0002237	abnormal nasal cavity morphology	"any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0004097	abnormal cerebellar cortex morphology	"any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Zfp423^nur12/Zfp423^nur12 Genetic Background: involves: BALB/c * C57BL/6 * C3H Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0005236	abnormal olfactory nerve morphology	"anomalous structure of the first cranial nerve, which conveys the sense of smell" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0006092	abnormal olfactory neuron morphology	"malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]	Show Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺,Omp^tm4(cre)Mom/Omp⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Omp^tm1Mom/Omp⁺,Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129S2/SvPas
MP:0008221	abnormal hippocampal commissure morphology	"any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0008534	enlarged fourth ventricle	"increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0008572	abnormal Purkinje cell dendrite morphology	"any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0008789	abnormal olfactory epithelium morphology	"any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0009719	reduced cerebellar foliation	"the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0009804	abnormal interventricular foramen morphology	"any structural anomaly of the paired channels that connect the lateral and third ventricles and allows cerebrospinal fluid produced in the lateral ventricles to flow into the third ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009965	abnormal cerebellum lateral hemisphere morphology	"any structural anomaly of the most lateral paired regions of the cerebellum; the lateral zone receives input from the parietal cortex via pontocerebellar mossy fibers regarding the location and position of the body and integrates input signals with indications of muscle activity" [http://www.spiritus-temporis.com/cerebellum/anatomy.html, ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0009968	abnormal cerebellar granule cell proliferation	"any anomaly in the ability of a cerebellar granule cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0011083	complete lethality at weaning	"premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]	Show Allelic Composition: Cntnap1^tm1Pele/Cntnap1^tm1Pele Genetic Background: Not Specified Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: Not Specified
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Zfp423^Gt(XB409)Byg/Zfp423^Gt(XB409)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012263	decreased hindbrain size	"size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]	Show Allelic Composition: Zfp423^tm1.2Ngc/Zfp423^tm1.2Ngc Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1
MP:0020527	small thalamus	"decreased size of the thalamus" [MGI:smb]	Show Allelic Composition: Zfp423^tm1Reed/Zfp423^tm1Reed Genetic Background: involves: 129 * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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