ENSGALG00000040276


Gallus gallus

Features
Gene ID: ENSGALG00000040276
  
Biological name :RUNX2
  
Synonyms : runt related transcription factor 2 / RUNX2
  
Possible biological names infered from orthology : Q08775 / Q13950
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 109770191
Gene end: 109917314
  
Corresponding Affymetrix probe sets: Gga.157.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050655
NCBI entrez gene - 373919     See in Manteia.
RefSeq - XM_015285083
RefSeq - NM_204128
RefSeq - XM_015285081
RefSeq - XM_015285082
RefSeq - XM_015285080
RefSeq Peptide - NP_989459
swissprot - Q8UVG3
Ensembl - ENSGALG00000040276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx2aENSDARG00000040261Danio rerio
 RUNX2ENSG00000124813Homo sapiens
 Runx2ENSMUSG00000039153Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RUNX1 / runt related transcription factor 1 / Q01196*ENSGALG0000001602258
RUNX3 / runt related transcription factor 3 / Q13761* / Q64131*ENSGALG0000004337256


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002051 osteoblast fate commitment IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0035115 embryonic forelimb morphogenesis IEA
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0045667 regulation of osteoblast differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060591 chondroblast differentiation IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 biological_processGO:1990079 cartilage homeostasis IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by RUNX2
Regulation of RUNX2 expression and activity
RUNX2 regulates osteoblast differentiation
RUNX2 regulates bone development


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000035610 PPM1D / protein phosphatase, Mg2+/Mn2+ dependent 1D / O15297* / Q9QZ67* / Protein phosphatase 1D *  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000041432 STUB1 / Q5ZHY5 / STIP1 homology and U box-containing protein 1 / Q9UNE7* / Q9WUD1*  / reaction / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000004386 SOX9 / P48434 / Transcription factor SOX-9 / Q04887* / P48436* / SRY-box 9*  / complex / reaction






 

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