ENSGALG00000004386


Gallus gallus

Features
Gene ID: ENSGALG00000004386
  
Biological name :SOX9
  
Synonyms : P48434 / SOX9 / Transcription factor SOX-9
  
Possible biological names infered from orthology : P48436 / Q04887 / SRY-box 9
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 8866456
Gene end: 8869366
  
Corresponding Affymetrix probe sets: Gga.4543.1.S1_at (Chicken Array)   Gga.5505.1.S1_at (Chicken Array)   Gga.890.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037718
NCBI entrez gene - 374148     See in Manteia.
RefSeq - NM_204281
RefSeq Peptide - NP_989612
swissprot - P48434
Ensembl - ENSGALG00000004386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox9aENSDARG00000003293Danio rerio
 SOX9ENSG00000125398Homo sapiens
 Sox9ENSMUSG00000000567Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOX10 / Q9W757 / Transcription factor SOX-10 / Q04888* / P56693* / SRY-box 10*ENSGALG0000001229054
SOX8 / transcription factor SOX-8 / Q04886* / P57073* / SRY-box 8* / SRY (sex determining region Y)-box 8*ENSGALG0000000526352
SOX17* / Q61473* / Q9H6I2* / SRY-box 17* / Transcription factor SOX-17 *ENSGALG0000003299421
SOX18 / transcription factor SOX-18 / P35713* / P43680* / SRY-box 18*ENSGALG0000003411820
SOX17 / transcription factor SOX-17 / Q61473* / Q9H6I2* / SRY-box 17*ENSGALG0000003285120
SOX7* / Q9BT81* / P40646* / SRY-box 7* / AC105001.2* / SRY (sex determining region Y)-box 7*ENSGALG0000004129619
SOX4 / transcription factor SOX-4 / Q06831* / Q06945* / SRY-box 4*ENSGALG0000003649717
SOX2 / P48430 / Transcription factor SOX-2 / P48431* / SRY-box 2*ENSGALG0000004346016
SOX1 / transcription factor SOX-1 / O00570* / P53783* / SRY-box 1*ENSGALG0000003035315
SOX12 / SRY-box 12 / O15370* / Q04890* / Transcription factor SOX-12 *ENSGALG0000003595114
SOX14 / Q9W7R6 / Transcription factor SOX-14 / Q04892* / O95416* / SRY-box 14*ENSGALG0000003735214
SOX21 / Q9W7R5 / Transcription factor SOX-21 / Q9Y651* / Q811W0* / SRY-box 21*ENSGALG0000003515713


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal
 IPR029548  Transcription factor SOX-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEP
 biological_processGO:0001708 cell fate specification IEA
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001894 tissue homeostasis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0002683 negative regulation of immune system process IEA
 biological_processGO:0003170 heart valve development IEP
 biological_processGO:0003179 heart valve morphogenesis IEA
 biological_processGO:0003188 heart valve formation IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA
 biological_processGO:0003415 chondrocyte hypertrophy IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010564 regulation of cell cycle process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0014036 neural crest cell fate specification IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0019100 male germ-line sex determination IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030238 male sex determination IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IEA
 biological_processGO:0030858 positive regulation of epithelial cell differentiation IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0030903 notochord development IEA
 biological_processGO:0030916 otic vesicle formation IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032808 lacrimal gland development IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IMP
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035622 intrahepatic bile duct development IEA
 biological_processGO:0036032 neural crest cell delamination IMP
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IEA
 biological_processGO:0048566 embryonic digestive tract development IMP
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060008 Sertoli cell differentiation IEA
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060018 astrocyte fate commitment IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060174 limb bud formation IEA
 biological_processGO:0060221 retinal rod cell differentiation IEA
 biological_processGO:0060290 transdifferentiation IMP
 biological_processGO:0060350 endochondral bone morphogenesis IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060487 lung epithelial cell differentiation IEA
 biological_processGO:0060512 prostate gland morphogenesis IEA
 biological_processGO:0060517 epithelial cell proliferation involved in prostatic bud elongation IEA
 biological_processGO:0060532 bronchus cartilage development IEA
 biological_processGO:0060534 trachea cartilage development IEA
 biological_processGO:0060729 intestinal epithelial structure maintenance IEA
 biological_processGO:0060784 regulation of cell proliferation involved in tissue homeostasis IEA
 biological_processGO:0061035 regulation of cartilage development IDA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0061046 regulation of branching involved in lung morphogenesis IEA
 biological_processGO:0061138 morphogenesis of a branching epithelium IEA
 biological_processGO:0061145 lung smooth muscle development IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070168 negative regulation of biomineral tissue development IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070384 Harderian gland development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071300 cellular response to retinoic acid IEP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071504 cellular response to heparin IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071599 otic vesicle development IEA
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 biological_processGO:0072034 renal vesicle induction IEA
 biological_processGO:0072170 metanephric tubule development IEA
 biological_processGO:0072189 ureter development IEA
 biological_processGO:0072190 ureter urothelium development IEA
 biological_processGO:0072193 ureter smooth muscle cell differentiation IEA
 biological_processGO:0072197 ureter morphogenesis IEA
 biological_processGO:0072289 metanephric nephron tubule formation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0090184 positive regulation of kidney development IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090300 positive regulation of neural crest formation IMP
 biological_processGO:0097065 anterior head development IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IEA
 biological_processGO:1902027 positive regulation of cartilage condensation IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903011 negative regulation of bone development IMP
 biological_processGO:2000020 positive regulation of male gonad development IEA
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IEA
 biological_processGO:2000741 positive regulation of mesenchymal stem cell differentiation IEA
 biological_processGO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0035326 enhancer binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0044390 ubiquitin-like protein conjugating enzyme binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0097157 pre-mRNA intronic binding IEA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / complex / reaction






 

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