ENSMUSG00000000567


Mus musculus

Features
Gene ID: ENSMUSG00000000567
  
Biological name :Sox9
  
Synonyms : Q04887 / Sox9 / Transcription factor SOX-9
  
Possible biological names infered from orthology : P48436 / SRY-box 9
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 112782224
Gene end: 112787760
  
Corresponding Affymetrix probe sets: 10382328 (MoGene1.0st)   1424950_at (Mouse Genome 430 2.0 Array)   1433889_at (Mouse Genome 430 2.0 Array)   1451538_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000579
NCBI entrez gene - 20682     See in Manteia.
MGI - MGI:98371
RefSeq - NM_011448
RefSeq Peptide - NP_035578
swissprot - Q04887
Ensembl - ENSMUSG00000000567
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox9aENSDARG00000003293Danio rerio
 SOX9ENSGALG00000004386Gallus gallus
 SOX9ENSG00000125398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300653
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417646
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590221
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647020
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306020
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*ENSMUSG0000007643117
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601416
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463716
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517916
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363216
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181715
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128714
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151714
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374713
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903612


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022151  Sox developmental protein N-terminal
 IPR029548  Transcription factor SOX-9
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001502 cartilage condensation ISS
 biological_processGO:0001503 ossification IEP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEP
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002062 chondrocyte differentiation ISS
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0002683 negative regulation of immune system process IMP
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0003188 heart valve formation IMP
 biological_processGO:0003203 endocardial cushion morphogenesis IMP
 biological_processGO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA
 biological_processGO:0003415 chondrocyte hypertrophy IMP
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0007417 central nervous system development IEP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010564 regulation of cell cycle process IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0014036 neural crest cell fate specification ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0019100 male germ-line sex determination IMP
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030238 male sex determination IGI
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IMP
 biological_processGO:0030858 positive regulation of epithelial cell differentiation IMP
 biological_processGO:0030879 mammary gland development IEP
 biological_processGO:0030903 notochord development IEP
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IEA
 biological_processGO:0032808 lacrimal gland development IMP
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035622 intrahepatic bile duct development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IGI
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060008 Sertoli cell differentiation IMP
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060018 astrocyte fate commitment IGI
 biological_processGO:0060041 retina development in camera-type eye IGI
 biological_processGO:0060174 limb bud formation IEP
 biological_processGO:0060221 retinal rod cell differentiation IGI
 biological_processGO:0060350 endochondral bone morphogenesis IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060487 lung epithelial cell differentiation IMP
 biological_processGO:0060512 prostate gland morphogenesis IMP
 biological_processGO:0060517 epithelial cell proliferation involved in prostatic bud elongation IMP
 biological_processGO:0060532 bronchus cartilage development IMP
 biological_processGO:0060534 trachea cartilage development IMP
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0060784 regulation of cell proliferation involved in tissue homeostasis IMP
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0061046 regulation of branching involved in lung morphogenesis IMP
 biological_processGO:0061138 morphogenesis of a branching epithelium IMP
 biological_processGO:0061145 lung smooth muscle development IMP
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070168 negative regulation of biomineral tissue development IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070384 Harderian gland development IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IDA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:0071504 cellular response to heparin IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071599 otic vesicle development IEP
 biological_processGO:0071773 cellular response to BMP stimulus ISS
 biological_processGO:0072034 renal vesicle induction IMP
 biological_processGO:0072170 metanephric tubule development IEP
 biological_processGO:0072189 ureter development IGI
 biological_processGO:0072190 ureter urothelium development IEP
 biological_processGO:0072193 ureter smooth muscle cell differentiation IMP
 biological_processGO:0072197 ureter morphogenesis IGI
 biological_processGO:0072289 metanephric nephron tubule formation IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090184 positive regulation of kidney development IGI
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0097065 anterior head development IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1901203 positive regulation of extracellular matrix assembly IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:2000020 positive regulation of male gonad development IEA
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IMP
 biological_processGO:2000741 positive regulation of mesenchymal stem cell differentiation IEA
 biological_processGO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis IMP
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0097157 pre-mRNA intronic binding IDA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Men1tm1Mmey/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Sox9tm4.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Gnai2tm2.1Lbi/Gnai2tm2.1Lbi,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gnai2tm2.1Lbi/Gnai2+,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000158 absent sternum "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm3.1Tlu/Sox9tm3.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000282 abnormal atrial septum morphology "abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Sox9tm1Gsr/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+,Tg(SFTPC-rtTA)5Jaw/0
Genetic Background: Not Specified

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000440 domed skull 
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Magel2tm1.1Mus/Magel2+
Genetic Background: B6.129S2-Magel2tm1.1Mus

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000574 abnormal foot pad morphology "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+
Genetic Background: 129S/Sv-Col2a1tm1(SOX9)Crm

Allelic Composition: Sox9tm4.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Sox9tm4.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm3.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rev3ltm1Ndew/Rev3ltm1Ndew,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrtm1Ofc/Atrtm1Ofc,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrtm1Ofc/Atrtm1Ofc,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Men1tm1Mmey/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9tm1(cre/ERT2)Haak
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

Allelic Composition: Sox9tm1(cre/ERT2)Haak/Sox9+
Genetic Background: B6.129S7-Sox9tm1(cre/ERT2)Haak

Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * CD-1

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Sox9tm2.1Crm/Sox9tm2.1Crm
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002256 abnormal laryngeal cartilage morphology "any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Trp53tm1Elee/Trp53tm1Elee,Tg(Wap-rtTA-cre)10Whl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9+,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Sox9tm1Gsr/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002785 absent Leydig cells "lack of the interstitial cells of the seminiferous tubules that secrete testosterone " [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002898 absent cartilage "absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm3.1Tlu/Sox9tm3.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0003417 premature endochondral bone ossification "early onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Sox9tm4.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0003589 abnormal ureter physiology "anomalous function of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003854 abnormal forelimb stylopod morphology 
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Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm3.1Tlu/Sox9tm3.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm3.1Tlu/Sox9tm3.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004204 absent stapes "absence of the smallest and innermost of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004318 absent incus "absence of the middle of the three auditory ossicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004319 absent malleus "absence of the largest of the three auditory ossicles, which resembles a club or hammer" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004343 small scapula "reduced size of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004344 scapular bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm3.1Tlu/Sox9tm3.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * SJL) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL)

 MP:0004347 abnormal scapular spine morphology "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004439 absent Meckel s cartilage "absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004506 abnormal pubic bone morphology "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnai2tm2.1Lbi/Gnai2tm2.1Lbi,Gnai3tm1Lbi/Gnai3tm1Lbi,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004692 small pubic bone "reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004880 lung cysts 
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm4.1Tlu/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

Allelic Composition: Sox9tm4.1Tlu/Sox9tm4.1Tlu,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
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Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005354 abnormal ilium morphology "structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129S4/SvJae * CD-1

Allelic Composition: Sox9tm2Gsr/Sox9tm2Gsr
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
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Allelic Composition: Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: C.Cg-Tnfrsf9tm1Byk

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Lmx1b,ALPP)Rjo/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005652 sex reversal "development of the reproductive system is inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Mtz/Ppargtm1.1Mtz
Genetic Background: involves: C57BL/6

Allelic Composition: Sox8tm1Weg/Sox8tm1Weg,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+,Tg(tetO-Vegfa)1Kesh/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0006107 abnormal atrioventricular canal morphology "malformation or anomaly in development of the common canal connecting the primordial atrium and ventricle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93610]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0006121 mitral valve calcification "pathologic deposition of calcium salts in the mitral valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9+,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm2.1Crm/Sox9tm2.1Crm
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006424 absent testis cords "missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [J:104330, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008384 absent nasal capsule "absence of the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008385 absent basisphenoid bone "absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008386 absent styloid process "absence of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone to join the tympanic portion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009139 failure of Mullerian duct regression "failure of the transient embryonic paramesonephric ducts, which normally develop into the oviduct, uterus, cervix and upper vagina in the female, to regress in the male; persistence of Mullerian ducts is typically consistent with a loss of anti-Mullerian hormone signaling and may allow development of the female reproductive tract in males" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009186 decreased PP cell number "reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009247 meteorism "swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam17tm1.2Bbl/Adam17tm1.2Bbl,Sox9tm3(cre)Crm/Sox9+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sox9tm2Crm/Sox9+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0009910 bifurcated tongue "tongue is split into two halves at the anterior tip; this is normal in some animals such as reptiles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0009915 absent hyoid bone lesser horns "absence of shorter and more medial of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0010587 conotruncal ridge hypoplasia "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0010684 abnormal hair follicle outer root sheath morphology "any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010686 abnormal hair follicle matrix region morphology "any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath" [PMID:19211055]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Col2a1tm1(SOX9)Crm/Col2a1+,Sox9tm1Crm/Sox9+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Sox9tm2Crm/Sox9+,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Zap70m3Btlr/Zap70m3Btlr
Genetic Background: C57BL/6J-Zap70m3Btlr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Sox9tm2.1Crm/Sox9tm2.1Crm
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc13a5tm1.2Helf/Slc13a5+
Genetic Background: B6.Cg-Slc13a5tm1.2Helf

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1tm1M,Tg(tetO-Foxg1)1Lai/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011195 increased hair follicle apoptosis "greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops" [MGI:mnk]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011210 abnormal temporomandibular joint morphology "any structural anomaly of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones" [ISBN:0-683-40008-8]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

 MP:0011426 abnormal ureter smooth muscle morphology "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * NMRI

Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0011480 impaired ureteric peristalsis "any anomaly in the wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, thus propelling urine from the kidney pelvis to the urinary bladder" [MGI:anna]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI * SJL

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Sox9Bbfc/Sox9+
Genetic Background: C57BL/6J-Sox9Bbfc/GrsrJ

 MP:0012756 impaired cranial neural crest cell differentiation "abnormal or arrest of differentiation or patterning of the cranial neural crest cells" [MGI:anna]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Krt19tm1(cre)Mmt/Krt19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013013 abnormal trunk neural crest cell morphology "any structural anomaly of the neural crest cells (NCCs) that arise from the trunk neural crest (located between the vagal and sacral neural crest) and differentiate into a variety of cell types, including melanocytes, the neurons and glia of the dorsal root and sympathetic ganglia, Schwann (precursor) cells, chromaffin cells of the adrenal medulla, and the nerve clusters surrounding the aorta" [http://www.ncbi.nlm.nih.gov/books/NBK10065/, MGI:anna]
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Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0013014 increased trunk neural crest cell apoptosis "increased number of trunk neural crest cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Sox8tm1Weg/Sox8+,Sox9tm2Crm/Sox9tm2Crm,Tg(Nr5a1-cre)5Asc/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Zap70m3Btlr/Zap70m3Btlr
Genetic Background: C57BL/6J-Zap70m3Btlr

 MP:0030162 absent hyoid bone body "absence of the main curve of the hyoid bone from which the horns extend" [MGI:anna]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

 MP:0030588 decreased pancreatic alpha cell mass "reduced total physical bulk or volume of a pancreatic alpha cell compared to the normal state" [MGI:anna]
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Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129S4/SvJae * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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