Manteia

ENSMUSG00000063632

Mus musculus

Features

Gene ID:	ENSMUSG00000063632

Biological name :	Sox11

Synonyms :	Q7M6Y2 / Sox11 / Transcription factor SOX-11

Possible biological names infered from orthology :	P35716 / SRY-box 11

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	A2
Gene start:	27334264
Gene end:	27342574

Corresponding Affymetrix probe sets:	10399725 (MoGene1.0st) 1429051_s_at (Mouse Genome 430 2.0 Array) 1429372_at (Mouse Genome 430 2.0 Array) 1436790_a_at (Mouse Genome 430 2.0 Array) 1453002_at (Mouse Genome 430 2.0 Array) 1453125_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000078070 NCBI entrez gene - 20666 See in Manteia. MGI - MGI:98359 RefSeq - NM_009234 RefSeq Peptide - NP_033260 swissprot - Q7M6Y2 Ensembl - ENSMUSG00000063632

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sox11a	ENSDARG00000077811	Danio rerio
sox11b	ENSDARG00000095743	Danio rerio
SOX11	ENSG00000176887	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*	ENSMUSG00000076431	41
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*	ENSMUSG00000051817	32
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*	ENSMUSG00000063060	22
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*	ENSMUSG00000033006	21
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*	ENSMUSG00000024176	21
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*	ENSMUSG00000025902	20
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*	ENSMUSG00000000567	20
Sox3 / SRY-box 3 / P41225*	ENSMUSG00000045179	19
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*	ENSMUSG00000096014	19
Sox2 / SRY-box 2 / P48431*	ENSMUSG00000074637	19
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*	ENSMUSG00000046470	19
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*	ENSMUSG00000061517	18
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*	ENSMUSG00000053747	18
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*	ENSMUSG00000041287	16
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*	ENSMUSG00000069036	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR009071	High mobility group box domain
IPR017386	Transcription factor SOX-11/4
IPR029551	Transcription factor SOX-11
IPR036910	High mobility group box domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0001501	skeletal system development	IMP
biological_process	GO:0001822	kidney development	IEA
biological_process	GO:0001841	neural tube formation	IMP
biological_process	GO:0002089	lens morphogenesis in camera-type eye	IMP
biological_process	GO:0003151	outflow tract morphogenesis	IMP
biological_process	GO:0003211	cardiac ventricle formation	IMP
biological_process	GO:0003357	noradrenergic neuron differentiation	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006412	translation	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0014003	oligodendrocyte development	IEA
biological_process	GO:0014009	glial cell proliferation	IMP
biological_process	GO:0014032	neural crest cell development	IMP
biological_process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IEA
biological_process	GO:0021510	spinal cord development	IMP
biological_process	GO:0021782	glial cell development	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030182	neuron differentiation	IEA
biological_process	GO:0030513	positive regulation of BMP signaling pathway	IMP
biological_process	GO:0035332	positive regulation of hippo signaling	IMP
biological_process	GO:0035914	skeletal muscle cell differentiation	IMP
biological_process	GO:0045666	positive regulation of neuron differentiation	IEA
biological_process	GO:0045669	positive regulation of osteoblast differentiation	IEA
biological_process	GO:0045778	positive regulation of ossification	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046887	positive regulation of hormone secretion	IMP
biological_process	GO:0048485	sympathetic nervous system development	IMP
biological_process	GO:0048557	embryonic digestive tract morphogenesis	IMP
biological_process	GO:0048704	embryonic skeletal system morphogenesis	IMP
biological_process	GO:0050672	negative regulation of lymphocyte proliferation	IEA
biological_process	GO:0050769	positive regulation of neurogenesis	IDA
biological_process	GO:0060022	hard palate development	IMP
biological_process	GO:0060023	soft palate development	IMP
biological_process	GO:0060174	limb bud formation	IMP
biological_process	GO:0060253	negative regulation of glial cell proliferation	IEA
biological_process	GO:0060412	ventricular septum morphogenesis	IMP
biological_process	GO:0060425	lung morphogenesis	IMP
biological_process	GO:0060548	negative regulation of cell death	IMP
biological_process	GO:0060563	neuroepithelial cell differentiation	IMP
biological_process	GO:0061029	eyelid development in camera-type eye	IMP
biological_process	GO:0061053	somite development	IMP
biological_process	GO:0061303	cornea development in camera-type eye	IMP
biological_process	GO:0061386	closure of optic fissure	IMP
biological_process	GO:0072395	signal transduction involved in cell cycle checkpoint	IEA
biological_process	GO:2000648	positive regulation of stem cell proliferation	IEA
biological_process	GO:2000678	negative regulation of transcription regulatory region DNA binding	IEA
biological_process	GO:2001111	positive regulation of lens epithelial cell proliferation	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001158	enhancer sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	ISO
molecular_function	GO:0008135	translation factor activity, RNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmpr2^tm1Mmue/Bmpr2⁺,Smad1^tm1Rjle/Smad1⁺ Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000159	abnormal xiphoid process	"malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺,Tead2^tm1Hssk/Tead2^tm1Hssk Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000287	heart valve hypoplasia	"decreased number of cells of the heart valves, leading to decreased size or bulk" [J:45302]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmpr2^tm1Mmue/Bmpr2⁺,Smad1^tm1Rjle/Smad1⁺ Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺,Tead2^tm1Hssk/Tead2^tm1Hssk Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000457	maxilla hypoplasia	"arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Bmpr2^tm1Mmue/Bmpr2⁺,Smad1^tm1Rjle/Smad1⁺ Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Bmpr2^tm1Mmue/Bmpr2⁺,Smad1^tm1Rjle/Smad1⁺ Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000762	abnormal tongue morphology	"anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bmpr2^tm1Mmue/Bmpr2⁺,Smad1^tm1Rjle/Smad1⁺ Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo
MP:0000930	wavy neural tube	"undulations in the embryonic neural tube" [J:37888]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001008	abnormal sympathetic ganglia morphology	"malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Sox11^tm1Weg/Sox11^tm1Weg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0001017	abnormal stellate ganglion morphology	"malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0001052	abnormal muscle innervation	"malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Sox11^tm2.1Weg/Sox11^tm2.1Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1Vlf/Sox4^tm1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001268	barrel chest	"distended circumference of the thoracic and abdominal areas" [J:55583]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Sox11^tm2.1Weg/Sox11^tm2.1Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1Vlf/Sox4^tm1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0001333	absent optic nerve	"absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001344	blepharoptosis	"ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Sox11^tm2.1Weg/Sox11^tm2.1Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1Vlf/Sox4^tm1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.1Weg/Sox11^tm2.1Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1Vlf/Sox4^tm1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002264	abnormal bronchus morphology	"any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0002691	small stomach	"reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002746	abnormal semilunar valve morphology	"malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺,Tead2^tm1Hssk/Tead2^tm1Hssk Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0003078	aphakia	"absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003203	increased neuron apoptosis	"increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003732	abnormal outer plexiform layer morphology	"malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0003861	abnormal nervous system development	"impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Sox11^tm1Weg/Sox11^tm1Weg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0004187	cardia bifida	"failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0004251	failure of looping morphogenesis	"failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004322	abnormal sternebra morphology	"any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0004323	sternum hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, in the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0004452	abnormal pterygoid process morphology	"any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004573	absent limb buds	"missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0005109	abnormal talus morphology	"malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005170	cleft lip	"defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0005252	abnormal meibomian gland morphology	"structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0005574	decreased breathing frequency	"fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0006073	abnormal retinal bipolar cell morphology	"anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0006221	optic nerve hypoplasia	"less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008068	absent retinal ganglion cell	"absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008106	decreased amacrine cell number	"reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008265	abnormal hippocampus CA2 region morphology		Show Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008277	abnormal sternum ossification	"anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008283	small hippocampus	"reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0008458	abnormal cortical ventricular zone morphology	"any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0008507	thin retinal ganglion layer	"reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008510	absent retinal ganglion layer	"absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008511	thin retinal inner nuclear layer	"reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0008514	absent retinal inner plexiform layer	"absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0009284	abnormal sympathetic neuron innervation	"defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo,Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺ Genetic Background: involves: 129S7/SvEvBrd
MP:0009450	abnormal axon fasiculation	"anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0009674	decreased birth weight	"reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0009728	abnormal calcaneum morphology	"any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009768	impaired somite development	"atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0009885	abnormal palatal shelf elevation	"any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0009888	palatal shelves fail to meet at midline	"polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm1.1Llei/Sox11^tm1.1Llei Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0010082	sternebra fusion	"appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0010395	abnormal branchial arch development	"abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺,Tead2^tm1Hssk/Tead2^tm1Hssk Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0010454	abnormal truncus arteriosis septation	"anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0010785	abnormal stomach pyloric region morphology	"any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Msr1^tm1Csk/Msr1^tm1Csk Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Sox11^tm1.2Llei/Sox11^tm1.2Llei Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0011261	abnormal limb mesenchyme morphology	"any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.1Weg/Sox11^tm2.1Weg,Sox12^tm2.1Weg/Sox12^tm2.1Weg,Sox4^tm1Vlf/Sox4^tm1Vlf Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0011262	abnormal branchial arch mesenchyme morphology	"any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Bicc1^b2b222Clo/Bicc1^b2b222Clo Genetic Background: C57BL/6J-Bicc1^b2b222Clo Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg,Sox4^tm1.1Vlf/Sox4^tm1.1Vlf Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0030005	increased retinal apoptosis	"increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Sox4^tm1Vlf/Sox4^tm1Vlf,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
MP:0030026	small Meckel s cartilage	"reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]	Show Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
MP:0030029	wide cranial sutures	"an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]	Show Allelic Composition: Sox11^tm2.2Weg/Sox11⁺,Sox4^tm1.1Vlf/Sox4⁺ Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Sox11^tm2.2Weg/Sox11^tm2.2Weg Genetic Background: involves: 129 * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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