ENSMUSG00000076431


Mus musculus

Features
Gene ID: ENSMUSG00000076431
  
Biological name :Sox4
  
Synonyms : Q06831 / Sox4 / Transcription factor SOX-4
  
Possible biological names infered from orthology : Q06945 / SRY-box 4
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 28948919
Gene end: 28953713
  
Corresponding Affymetrix probe sets: 10408450 (MoGene1.0st)   1419155_a_at (Mouse Genome 430 2.0 Array)   1419156_at (Mouse Genome 430 2.0 Array)   1419157_at (Mouse Genome 430 2.0 Array)   1433575_at (Mouse Genome 430 2.0 Array)   1443778_at (Mouse Genome 430 2.0 Array)   1449370_at (Mouse Genome 430 2.0 Array)   1458332_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100013
NCBI entrez gene - 20677     See in Manteia.
MGI - MGI:98366
RefSeq - NM_009238
RefSeq Peptide - NP_033264
swissprot - Q06831
Ensembl - ENSMUSG00000076431
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox4aENSDARG00000004588Danio rerio
 sox4bENSDARG00000098834Danio rerio
 SOX4ENSGALG00000036497Gallus gallus
 SOX4ENSG00000124766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sox11 / Q7M6Y2 / Transcription factor SOX-11 / P35716* / SRY-box 11*ENSMUSG0000006363237
Sox12 / Q04890 / Transcription factor SOX-12 / O15370* / SRY-box 12*ENSMUSG0000005181736
Sox10 / Q04888 / Transcription factor SOX-10 / P56693* / SRY-box 10*ENSMUSG0000003300620
Sox9 / Q04887 / Transcription factor SOX-9 / P48436* / SRY-box 9*ENSMUSG0000000056719
Sox7 / P40646 / SRY (sex determining region Y)-box 7 / Q9BT81* / SRY-box 7*ENSMUSG0000006306019
Sox8 / Q04886 / SRY (sex determining region Y)-box 8 / P57073* / SRY-box 8*ENSMUSG0000002417618
Sox3 / SRY-box 3 / P41225*ENSMUSG0000004517918
Sox18 / P43680 / Transcription factor SOX-18 / P35713* / SRY-box 18*ENSMUSG0000004647017
Sox1 / P53783 / Transcription factor SOX-1 / O00570* / SRY-box 1*ENSMUSG0000009601417
Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*ENSMUSG0000002590217
Sox2 / SRY-box 2 / P48431*ENSMUSG0000007463717
Sox15 / P43267 / SRY (sex determining region Y)-box 15 / O60248* / SRY-box 15*ENSMUSG0000004128716
Sox21 / Q811W0 / Transcription factor SOX-21 / Q9Y651* / SRY-box 21*ENSMUSG0000006151715
Sox14 / Q04892 / Transcription factor SOX-14 / O95416* / SRY-box 14*ENSMUSG0000005374714
Sry / Q05738 / sex determining region of Chr Y / Q05066* / sex determining region Y*ENSMUSG0000006903613


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR017386  Transcription factor SOX-11/4
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0002328 pro-B cell differentiation IMP
 biological_processGO:0003183 mitral valve morphogenesis IMP
 biological_processGO:0003211 cardiac ventricle formation IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003289 atrial septum primum morphogenesis IMP
 biological_processGO:0003357 noradrenergic neuron differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0014009 glial cell proliferation IMP
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0021782 glial cell development IMP
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0035019 somatic stem cell population maintenance IDA
 biological_processGO:0035910 ascending aorta morphogenesis IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042769 DNA damage response, detection of DNA damage IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IEA
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060174 limb bud formation IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0060563 neuroepithelial cell differentiation IMP
 biological_processGO:0060993 kidney morphogenesis IMP
 biological_processGO:0071333 cellular response to glucose stimulus IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2000761 positive regulation of N-terminal peptidyl-lysine acetylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0044798 nuclear transcription factor complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sox4Igt4/Sox4Igt4
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000287 heart valve hypoplasia "decreased number of cells of the heart valves, leading to decreased size or bulk" [J:45302]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001017 abnormal stellate ganglion morphology "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Sox11tm2.1Weg/Sox11tm2.1Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1Vlf/Sox4tm1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Sox11tm2.1Weg/Sox11tm2.1Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1Vlf/Sox4tm1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: M876b/Del(13)36H,Foxq1sa/Foxq1+
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Sox4Igt4/Sox4Igt4
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.1Weg/Sox11tm2.1Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1Vlf/Sox4tm1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Dac/Insr+,Sox4Igt4/Sox4+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sox4Igt4/Sox4+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003201 extremity edema "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004323 sternum hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004573 absent limb buds "missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Hoxa10tm1Ipc/Hoxa10+
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0005252 abnormal meibomian gland morphology "structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bbc3tm1Gpz/Bbc3tm1Gpz,Bnip3ltm1Ney/Bnip3ltm1Ney
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sox4Igt4/Sox4+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Sox4M91Ark/Sox4+
Genetic Background: involves: C3H/HeH

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0008068 absent retinal ganglion cell "absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0008510 absent retinal ganglion layer "absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0008514 absent retinal inner plexiform layer "absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Mesp2tm15.1(Lfng)Ysa/Mesp2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010395 abnormal branchial arch development "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0010417 subarterial ventricular septal defect "abnormal communications between the two lower chambers of the heart, located beneath the pulmonic valve, communicating with the RV outflow tract above the supraventricular crest, and are associated with aortic regurgitation secondary to the prolapse of the right aortic cusp" [http://emedicine.medscape.com]
Show

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010572 persistent right dorsal aorta "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010585 abnormal conotruncal ridge morphology "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010645 failure of conotruncal ridge closure "failure of the conotruncal ridges to develop from the conotruncus, meet at the midline and fuse to form the conotruncal septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010650 abnormal aorticopulmonary septum morphology "any structural anomaly of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Foxq1sa/Foxq1+,Sox4M91Ark/Del(13)36H
Genetic Background: involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sox5tm1Vlf/Sox5+,Sox6tm1Vlf/Sox6+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sox4Igt4/Sox4M91Ark
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Sox4Igt4/Sox4Igt4
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Sox4Igt4/Del(13)36H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Sox11tm2.1Weg/Sox11tm2.1Weg,Sox12tm2.1Weg/Sox12tm2.1Weg,Sox4tm1Vlf/Sox4tm1Vlf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011262 abnormal branchial arch mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Bicc1b2b222Clo/Bicc1b2b222Clo
Genetic Background: C57BL/6J-Bicc1b2b222Clo

Allelic Composition: Sox11tm2.2Weg/Sox11tm2.2Weg,Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Sox11tm2.2Weg/Sox11+,Sox4tm1.1Vlf/Sox4+
Genetic Background: involves: 129 * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / reaction / complex
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr