ENSMUSG00000024985


Mus musculus

Features
Gene ID: ENSMUSG00000024985
  
Biological name :Tcf7l2
  
Synonyms : Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box
  
Possible biological names infered from orthology : Q9NQB0 / transcription factor 7 like 2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 55741810
Gene end: 55933654
  
Corresponding Affymetrix probe sets: 10464084 (MoGene1.0st)   1425229_a_at (Mouse Genome 430 2.0 Array)   1426639_a_at (Mouse Genome 430 2.0 Array)   1429427_s_at (Mouse Genome 430 2.0 Array)   1429428_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107279
Ensembl peptide - ENSMUSP00000107278
Ensembl peptide - ENSMUSP00000107280
Ensembl peptide - ENSMUSP00000123428
Ensembl peptide - ENSMUSP00000119759
Ensembl peptide - ENSMUSP00000118661
Ensembl peptide - ENSMUSP00000118042
Ensembl peptide - ENSMUSP00000107291
Ensembl peptide - ENSMUSP00000107287
Ensembl peptide - ENSMUSP00000107286
Ensembl peptide - ENSMUSP00000107284
Ensembl peptide - ENSMUSP00000107283
Ensembl peptide - ENSMUSP00000107281
Ensembl peptide - ENSMUSP00000042950
Ensembl peptide - ENSMUSP00000050081
Ensembl peptide - ENSMUSP00000107273
Ensembl peptide - ENSMUSP00000107276
NCBI entrez gene - 21416     See in Manteia.
MGI - MGI:1202879
RefSeq - XM_017318135
RefSeq - XM_006526895
RefSeq - XM_006526897
RefSeq - XM_017318110
RefSeq - XM_017318111
RefSeq - XM_017318112
RefSeq - XM_017318113
RefSeq - XM_017318114
RefSeq - XM_017318115
RefSeq - XM_017318116
RefSeq - XM_017318117
RefSeq - XM_017318118
RefSeq - XM_017318119
RefSeq - XM_017318120
RefSeq - XM_017318121
RefSeq - XM_017318122
RefSeq - XM_017318123
RefSeq - XM_017318124
RefSeq - XM_017318125
RefSeq - XM_017318126
RefSeq - XM_017318127
RefSeq - XM_017318128
RefSeq - XM_017318129
RefSeq - XM_017318130
RefSeq - XM_017318131
RefSeq - XM_017318132
RefSeq - XM_017318133
RefSeq - XM_017318134
RefSeq - NM_001142918
RefSeq - NM_001142919
RefSeq - NM_001142920
RefSeq - NM_001142921
RefSeq - NM_001142922
RefSeq - NM_001142923
RefSeq - NM_001142924
RefSeq - NM_001331140
RefSeq - NM_001331143
RefSeq - NM_009333
RefSeq - XM_006526860
RefSeq - XM_006526861
RefSeq - XM_006526862
RefSeq - XM_006526863
RefSeq - XM_006526866
RefSeq - XM_006526867
RefSeq - XM_006526869
RefSeq - XM_006526885
RefSeq - XM_006526888
RefSeq - XM_006526890
RefSeq - XM_006526894
RefSeq Peptide - NP_001136396
RefSeq Peptide - NP_001318069
RefSeq Peptide - NP_001318072
RefSeq Peptide - NP_033359
RefSeq Peptide - NP_001136393
RefSeq Peptide - NP_001136394
RefSeq Peptide - NP_001136395
RefSeq Peptide - NP_001136390
RefSeq Peptide - NP_001136391
RefSeq Peptide - NP_001136392
swissprot - F6WBK9
swissprot - F6WPX2
swissprot - F6XQR1
swissprot - E9QQ91
swissprot - Q3V1G9
swissprot - Q924A0
swissprot - A0A0R4J1F7
swissprot - A0A0R4J1F9
swissprot - E9QQ90
swissprot - E9QQ89
swissprot - E9Q990
swissprot - D3Z2K5
swissprot - D3Z1L0
swissprot - D3Z002
swissprot - D3YWT3
swissprot - A0A0R4J1G1
swissprot - A0A0R4J1G0
Ensembl - ENSMUSG00000024985
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf7l2ENSDARG00000004415Danio rerio
 TCF7L2ENSGALG00000008883Gallus gallus
 Q9NQB0ENSG00000148737Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf7l1 / transcription factor 7 like 1 / Q9HCS4*ENSMUSG0000005579960
Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*ENSMUSG0000002798542
Tcf7 / Q00417 / transcription factor 7, T cell specific / P36402* / transcription factor 7*ENSMUSG0000000078226


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR013558  CTNNB1 binding, N-teminal
 IPR024940  Transcription factor TCF/LEF
 IPR027397  Catenin binding domain superfamily
 IPR028773  Transcription factor 7-like
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0005977 glycogen metabolic process IMP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030282 bone mineralization IGI
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030538 embryonic genitalia morphogenesis IGI
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032252 secretory granule localization IMP
 biological_processGO:0032350 regulation of hormone metabolic process IEA
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IMP
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043570 maintenance of DNA repeat elements IEA
 biological_processGO:0043588 skin development IGI
 biological_processGO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045722 positive regulation of gluconeogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046621 negative regulation of organ growth IMP
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IMP
 biological_processGO:0048557 embryonic digestive tract morphogenesis IGI
 biological_processGO:0048619 embryonic hindgut morphogenesis IGI
 biological_processGO:0048625 myoblast fate commitment IEA
 biological_processGO:0048641 regulation of skeletal muscle tissue development IMP
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048713 regulation of oligodendrocyte differentiation IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060325 face morphogenesis IGI
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1901142 insulin metabolic process IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0070369 beta-catenin-TCF7L2 complex IEA
 cellular_componentGO:0071664 catenin-TCF7L2 complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IGI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0045295 gamma-catenin binding IEA
 molecular_functionGO:0070016 armadillo repeat domain binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Repression of WNT target genes
RUNX3 regulates WNT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pnpla2tm1Rze/Pnpla2tm1Rze,Tg(Myh6-Pnpla2)94Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2em2Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em3Nobr/Tcf7l2em3Nobr
Genetic Background: involves: CD-1

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000339 decreased intestinal cell number "fewer than expected number of terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000636 enlarged pituitary gland "increased size of pituitary gland" [J:50053]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Tcf7l2tm3.1(cre/ERT2)Mrc/Tcf7l2+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tcf7l2tm1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdcd1tm1.1Liux/Pdcd1tm1.1Liux,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax7tm1(cre/ERT2)Gaka/Pax7+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l2tm1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: ApcMin/Apc+,Tcf7l2tm2.2Mrc/Tcf7l2+
Genetic Background: involves: C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0003686 abnormal eye muscle morphology "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l2tm3.1(cre/ERT2)Mrc/Tcf7l2+,Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004463 basisphenoid bone foramen "the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008130 abnormal pituitary intermediate lobe "any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0008366 enlarged adenohypophysis "increased size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt3ltm1Imx/Flt3ltm1Imx
Genetic Background: involves: C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2em2Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em3Nobr/Tcf7l2em3Nobr
Genetic Background: involves: CD-1

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2em2Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em3Nobr/Tcf7l2em3Nobr
Genetic Background: involves: CD-1

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2em1Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2+
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010158 abnormal intestine development "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010602 abnormal pulmonary valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010667 abnormal umbilical vein morphology "any structural anomaly of the vein that returns oxygenated blood from the placenta to the fetus through the umbilical cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010802 abnormal intestinal enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Narfltm1.1Fsl/Narfltm1.1Fsl,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm1.1(EGFP/cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tcf7l2em1Nobr/Tcf7l2em1Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em2Nobr/Tcf7l2em2Nobr
Genetic Background: involves: CD-1

Allelic Composition: Tcf7l2em3Nobr/Tcf7l2em3Nobr
Genetic Background: involves: CD-1

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6-Tcf7l2tm1a(EUCOMM)Wtsi

 MP:0011513 abnormal vertebral artery morphology "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013186 abnormal basilar artery morphology "any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm1.1(EGFP/cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.1Mrc
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl

Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0013792 abnormal small intestine goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm1.1(EGFP/cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Tcf7l2tm1.1(EGFP/cre)Mrc/Tcf7l2tm1.1(EGFP/cre)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013862 abnormal cecum position "abnormal placement of the large sac normally located at the ileum and large intestine junction" [ISBN:0-683-40008-8]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013876 absent ductus venosus valve "absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013943 abnormal ureter topology "abnormal position of the tube that conducts the urine from the renal pelvis to the bladder" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013945 abnormal elbow joint morphology 
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013977 symmetric azygos veins 
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013985 abnormal umbilical vein topology "abnormal position of the umbilical vein in relationship to other umbilical cord structures" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014021 heterochrony 
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014076 absent Paneth cells "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021611 Tert / O70372 / telomerase reverse transcriptase / O14746*  / complex / reaction
 ENSMUSG00000030079 P60122 / Ruvbl1 / RuvB-like protein 1 / Q9Y265* / RuvB like AAA ATPase 1*  / reaction / complex
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / reaction / complex
 ENSMUSG00000038256 Bcl9 / Q9D219 / B-cell CLL/lymphoma 9 protein / O00512* / B cell CLL/lymphoma 9*  / complex / reaction
 ENSMUSG00000042487 Leo1 / Q5XJE5 / RNA polymerase-associated protein LEO1 / Q8WVC0* / LEO1 homolog, Paf1/RNA polymerase II complex component*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000034910 Pygo1 / Q9D0P5 / pygopus 1 / Q9Y3Y4* / pygopus family PHD finger 1*  / reaction / complex
 ENSMUSG00000076431 Sox4 / Q06831 / Transcription factor SOX-4 / Q06945* / SRY-box 4*  / complex / reaction
 ENSMUSG00000025902 Sox17 / Q61473 / Transcription factor SOX-17 / Q9H6I2* / SRY-box 17*  / complex / reaction
 ENSMUSG00000070643 Sox13 / Q04891 / Transcription factor SOX-13 / Q9UN79* / SRY-box 13*  / reaction / complex
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / reaction / complex
 ENSMUSG00000037373 Ctbp1 / O88712 / C-terminal-binding protein 1 / Q13363*  / reaction / complex
 ENSMUSG00000026361 Cdc73 / Q8JZM7 / Parafibromin / Q6P1J9* / cell division cycle 73*  / reaction / complex
 ENSMUSG00000063382 Bcl9l / Q67FY2 / Mus musculus B cell CLL/lymphoma 9-like (Bcl9l), transcript variant 2, mRNA. / Q86UU0* / B cell CLL/lymphoma 9 like*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000047824 Pygo2 / pygopus 2 / Q9BRQ0* / pygopus family PHD finger 2*  / reaction / complex
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / complex / reaction
 ENSMUSG00000017376 Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*  / reaction






 

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