ENSMUSG00000028800


Mus musculus

Features
Gene ID: ENSMUSG00000028800
  
Biological name :Hdac1
  
Synonyms : Hdac1 / Histone deacetylase 1 / O09106
  
Possible biological names infered from orthology : Q13547
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 129516104
Gene end: 129542713
  
Corresponding Affymetrix probe sets: 10447004 (MoGene1.0st)   10516605 (MoGene1.0st)   1448246_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099657
NCBI entrez gene - 433759     See in Manteia.
MGI - MGI:108086
RefSeq - NM_008228
RefSeq Peptide - NP_032254
swissprot - O09106
swissprot - Q58E49
Ensembl - ENSMUSG00000028800
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hdac1ENSDARG00000015427Danio rerio
 HDAC1ENSGALG00000003297Gallus gallus
 HDAC1ENSG00000116478Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*ENSMUSG0000006106299
Hdac2 / histone deacetylase 2 / Q92769*ENSMUSG0000001977786
Hdac3 / histone deacetylase 3 / O15379*ENSMUSG0000002445453
Hdac8 / Q8VH37 / Histone deacetylase 8 / Q9BY41*ENSMUSG0000006756733
Hdac11 / Q91WA3 / Histone deacetylase 11 / Q96DB2*ENSMUSG0000003424518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000286  Histone deacetylase family
 IPR003084  Histone deacetylase
 IPR023696  Ureohydrolase domain superfamily
 IPR023801  Histone deacetylase domain
 IPR037138  Histone deacetylase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006346 methylation-dependent chromatin silencing ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation ISO
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0009913 epidermal cell differentiation IGI
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010870 positive regulation of receptor biosynthetic process ISO
 biological_processGO:0016575 histone deacetylation ISO
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0030182 neuron differentiation IGI
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IGI
 biological_processGO:0043922 negative regulation by host of viral transcription ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IGI
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway ISO
 biological_processGO:0060789 hair follicle placode formation IGI
 biological_processGO:0061029 eyelid development in camera-type eye IGI
 biological_processGO:0061198 fungiform papilla formation IGI
 biological_processGO:0070932 histone H3 deacetylation IDA
 biological_processGO:0070933 histone H4 deacetylation IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0000118 histone deacetylase complex IPI
 cellular_componentGO:0000785 chromatin ISO
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016580 Sin3 complex ISO
 cellular_componentGO:0016581 NuRD complex ISO
 cellular_componentGO:0017053 transcriptional repressor complex IPI
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004407 histone deacetylase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IDA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
 molecular_functionGO:0033558 protein deacetylase activity ISO
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0035851 Krueppel-associated box domain binding IPI
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0051059 NF-kappaB binding ISO
 molecular_functionGO:0070491 repressing transcription factor binding ISO
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Formation of the beta-catenin:TCF transactivating complex
Downregulation of SMAD2/3:SMAD4 transcriptional activity
HDACs deacetylate histones
Deactivation of the beta-catenin transactivating complex
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000384 distorted hair follicle pattern "twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001267 enlarged chest "wider diameter, or distended chest cavity" [J:18048]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Hdac2tm1.2Eno/Hdac2tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Raratm3.1Ipc/Raratm3.1Ipc
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Avy/A,Dnmt1MommeD2/Dnmt1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Bidtm1.1Ast/Bidtm1.1Ast
Genetic Background: involves: BALB/cJ * C57BL/6 * NZB

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002015 epithelioid cysts "abnormal membraneous sacs appearing in an epithelium" [J:51296]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2ctm1Bnno/Grin2ctm1Bnno
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Avy/A,Dnmt1MommeD2/Dnmt1+
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0004027 trisomy "presence of an extra chromosome in an otherwise diploid chromosome set" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

Allelic Composition: Hdac1tm1.1Shmc/Hdac1tm1.1Shmc,Hdac2tm1.1Shmc/Hdac2+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt,Tg(Fcer2a-cre)5Mbu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Trp53tm1Brd/Trp53+
Genetic Background: B6.129-Trp53tm1Brd Nf1tm1Fcr

 MP:0009598 thin epidermis stratum granulosum "decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010037 ectopic melanocytes "pigment producing cells are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010683 dilated hair follicle infundibulum "the luminal space of the hair follicle infundibulum is increased in volume or area, sometimes with an increase of contained fluid or sebum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2tm1.1Eno,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Avy/A,Dnmt1MommeD2/Dnmt1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Grin2ctm1Bnno/Grin2ctm1Bnno
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Hdac1tm1.2Pmt/Hdac1tm1.2Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Hdac1tm1Ics/Hdac1tm1Ics,Hdac2tm1.1Rdp/Hdac2tm1.1Rdp,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0012176 abnormal head development "anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]
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Allelic Composition: Hdac1tm1Sei/Hdac1tm1Sei
Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0012404 abnormal nail color "a variation in an expected nail color, that may be due to infection, inflammation or other causes" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Hdac1tm1.1Eno/Hdac1tm1.1Eno,Hdac2tm1.1Eno/Hdac2+,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0012405 abnormal nail matrix morphology "any structural anomaly of the nail-forming area of the nail bed comprised of a germinal matrix, responsible for most of the nail production, and the sterile matrix, a secondary site of nail production which is tightly adherent to the nail plate" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0013740 Meibomian gland hyperplasia "overdevelopment or increased size, usually due to an increased number of cells, of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate" [MGI:Anna, PMID:23792463]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0030038 abnormal periorbital region morphology "any structural anomaly of the region around the eye socket" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2.1Ksvo/Gt(ROSA)26Sortm2.1Ksvo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / complex / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / complex / reaction
 ENSMUSG00000042557 Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*  / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction
 ENSMUSG00000047407 Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*  / reaction / complex
 ENSMUSG00000062175 Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*  / reaction / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000049300 Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*  / reaction / complex
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000032280 Tle3 / Q08122 / transducin-like enhancer of split 3 / Q04726*  / complex
 ENSMUSG00000027985 Lef1 / P27782 / Lymphoid enhancer-binding factor 1 / Q9UJU2*  / complex
 ENSMUSG00000008305 Tle1 / Q62440 / Transducin-like enhancer protein 1 / Q04724* / transducin like enhancer of split 1*  / complex
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000019777 Hdac2 / histone deacetylase 2 / Q92769*  / complex
 ENSMUSG00000029249 Rest / Q8VIG1 / RE1-silencing transcription factor / Q13127*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex
 ENSMUSG00000034771 Tle2 / Q9WVB2 / transducin-like enhancer of split 2 / Q04725*  / complex
 ENSMUSG00000037896 Rcor1 / Q8CFE3 / REST corepressor 1 / Q9UKL0*  / complex
 ENSMUSG00000036940 Kdm1a / Q6ZQ88 / Mus musculus lysine (K)-specific demethylase 1A (Kdm1a), transcript variant 3, mRNA. / O60341* / lysine demethylase 1A*  / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024642 Tle4 / Q62441 / Transducin-like enhancer protein 4 / Q04727* / transducin like enhancer of split 4*  / complex






 

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