ENSMUSG00000047407


Mus musculus

Features
Gene ID: ENSMUSG00000047407
  
Biological name :Tgif1
  
Synonyms : P70284 / TGFB-induced factor homeobox 1 / Tgif1
  
Possible biological names infered from orthology : Q15583
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.3
Gene start: 70844205
Gene end: 70853546
  
Corresponding Affymetrix probe sets: 10452633 (MoGene1.0st)   1422286_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124970
Ensembl peptide - ENSMUSP00000125247
Ensembl peptide - ENSMUSP00000139438
Ensembl peptide - ENSMUSP00000130930
Ensembl peptide - ENSMUSP00000127139
Ensembl peptide - ENSMUSP00000060512
Ensembl peptide - ENSMUSP00000113192
Ensembl peptide - ENSMUSP00000115375
Ensembl peptide - ENSMUSP00000124168
NCBI entrez gene - 21815     See in Manteia.
MGI - MGI:1194497
RefSeq - XM_011246363
RefSeq - NM_001164074
RefSeq - NM_001164075
RefSeq - NM_001164076
RefSeq - NM_001164077
RefSeq - NM_009372
RefSeq - XM_006524031
RefSeq - XM_006524032
RefSeq Peptide - NP_001157548
RefSeq Peptide - NP_001157546
RefSeq Peptide - NP_001157547
RefSeq Peptide - NP_001157549
RefSeq Peptide - NP_033398
swissprot - F6TUU5
swissprot - G3UWC5
swissprot - A0A087WNP4
swissprot - E0CXJ4
swissprot - Q3TVD4
swissprot - E0CYI0
swissprot - P70284
swissprot - D3Z0Q5
Ensembl - ENSMUSG00000047407
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgif1ENSDARG00000059337Danio rerio
 TGIF1ENSGALG00000014795Gallus gallus
 TGIF1ENSG00000177426Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*ENSMUSG0000006217539
Tgif2lx2 / TGFB-induced factor homeobox 2-like, X-linked 2 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG0000010019422
Tgif2lx1 / TGFB-induced factor homeobox 2-like, X-linked 1 / Q8IUE1* / Q8IUE0* / TGIF2LX* / TGIF2LY* / TGFB induced factor homeobox 2 like, X-linked* / TGFB induced factor homeobox 2 like, Y-linked*ENSMUSG0000010013322
Meis2 / P97367 / Homeobox protein Meis2 / O14770* / Meis homeobox 2*ENSMUSG0000002721021
Meis1 / Q60954 / Homeobox protein Meis1 / O00470* / Meis homeobox 1*ENSMUSG0000002016021
Pknox2 / Q8BG99 / Homeobox protein PKNOX2 / Q96KN3* / PBX/knotted 1 homeobox 2*ENSMUSG0000003593419
O70477 / Pknox1 / Homeobox protein PKNOX1 / P55347* / PBX/knotted 1 homeobox 1*ENSMUSG0000000670517
Meis3 / P97368 / Homeobox protein Meis3 / Q99687* / Meis homeobox 3*ENSMUSG0000004142017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR008422  Homeobox KN domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010470 regulation of gastrulation IGI
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0038092 nodal signaling pathway IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IMP
 biological_processGO:0060041 retina development in camera-type eye IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008432 JUN kinase binding ISO
 molecular_functionGO:0070410 co-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1tm1Ychn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1tm1Ychn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1Fia/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Tgif1tm1Dwot/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Ychn/Tgif1tm1Ychn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0000935 abnormal folding of telencephalic vesicles "malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001784 abnormal fluid regulation "anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1+,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm2Mim
Genetic Background: involves: C57BL/6

Allelic Composition: Tgif1tm1Jxd/Tgif1tm1Jxd
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129 * C57BL/6)

Allelic Composition: Tgif1tm1Caw/Tgif1tm1Caw
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002767 situs ambiguus "abnormal organ position" [J:62608]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0003639 abnormal response to vitamins "altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shhtm2Amc/Shhtm2Amc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Tgif1tm1Dwot/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0004739 conductive hearing loss "progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1tm1Ychn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0011192 decreased embryonic epiblast cell proliferation "reduction in the expansion rate of the embryonic epiblast cells by cell division" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0011525 abnormal placenta intervillous maternal lacunae morphology "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0011529 increased placenta intervillous maternal lacunae size "increased size of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ednrbs-Btlr/Ednrbs-Btlr
Genetic Background: C57BL/6J-Ednrbs-Btlr

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012258 philtrum hypoplasia "underdevelopment or reduced size of the philtrum, usually due to a reduced number of cells" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012523 abnormal upper lip morphology "any structural anomaly of the muscular fold forming the superior border of the mouth" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0013227 small brain ventricles "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
Show

Allelic Composition: Tgif1tm1Ychn/Tgif1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030226 middle ear polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the middle ear" [MGI:anna]
Show

Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr