ENSMUSG00000024563


Mus musculus

Features
Gene ID: ENSMUSG00000024563
  
Biological name :Smad2
  
Synonyms : Mothers against decapentaplegic homolog 2 / Q62432 / Smad2
  
Possible biological names infered from orthology : Q15796 / SMAD family member 2
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E3
Gene start: 76241580
Gene end: 76305731
  
Corresponding Affymetrix probe sets: 10456764 (MoGene1.0st)   1420634_a_at (Mouse Genome 430 2.0 Array)   1442062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109563
Ensembl peptide - ENSMUSP00000132851
Ensembl peptide - ENSMUSP00000130115
Ensembl peptide - ENSMUSP00000129232
Ensembl peptide - ENSMUSP00000125883
Ensembl peptide - ENSMUSP00000025453
Ensembl peptide - ENSMUSP00000089439
NCBI entrez gene - 17126     See in Manteia.
MGI - MGI:108051
RefSeq - XM_017317842
RefSeq - NM_001252481
RefSeq - NM_001311070
RefSeq - NM_010754
RefSeq - XM_006525699
RefSeq Peptide - NP_001297999
RefSeq Peptide - NP_001239410
RefSeq Peptide - NP_034884
swissprot - E9PXA8
swissprot - E9Q3M0
swissprot - E9PZV6
swissprot - E9Q5P9
swissprot - Q62432
Ensembl - ENSMUSG00000024563
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad2ENSDARG00000006389Danio rerio
 ENSGALG00000014184Gallus gallus
 SMAD2ZENSGALG00000036001Gallus gallus
 SMAD2ENSG00000175387Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*ENSMUSG0000003240284
Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*ENSMUSG0000002154061
Smad1 / P70340 / SMAD family member 1 / Q15797*ENSMUSG0000003168160
Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*ENSMUSG0000002779658
Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*ENSMUSG0000002451540
Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*ENSMUSG0000003686725
Smad7 / O35253 / SMAD family member 7 / O15105*ENSMUSG0000002588024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily
 IPR036578  SMAD MH1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007182 common-partner SMAD protein phosphorylation ISO
 biological_processGO:0007183 SMAD protein complex assembly ISO
 biological_processGO:0007352 zygotic specification of dorsal/ventral axis ISO
 biological_processGO:0007369 gastrulation IGI
 biological_processGO:0007389 pattern specification process IGI
 biological_processGO:0007492 endoderm development IGI
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009749 response to glucose IGI
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0009880 embryonic pattern specification IGI
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030073 insulin secretion IGI
 biological_processGO:0030324 lung development IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway ISO
 biological_processGO:0031016 pancreas development IGI
 biological_processGO:0032924 activin receptor signaling pathway ISO
 biological_processGO:0035265 organ growth IGI
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0038092 nodal signaling pathway ISO
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048340 paraxial mesoderm morphogenesis IMP
 biological_processGO:0048589 developmental growth IGI
 biological_processGO:0048617 embryonic foregut morphogenesis IGI
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IGI
 biological_processGO:0051098 regulation of binding IDA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060039 pericardium development IGI
 biological_processGO:0060395 SMAD protein signal transduction IGI
 biological_processGO:0070723 response to cholesterol ISO
 biological_processGO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032444 activin responsive factor complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0071141 SMAD protein complex ISO
 cellular_componentGO:0071144 heteromeric SMAD protein complex ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019902 phosphatase binding ISO
 molecular_functionGO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0070410 co-SMAD binding ISO
 molecular_functionGO:0070411 I-SMAD binding ISO
 molecular_functionGO:0070412 R-SMAD binding ISO
 molecular_functionGO:0070878 primary miRNA binding ISO
 molecular_functionGO:0097718 disordered domain specific binding ISO


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm2Knk
Genetic Background: B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm2Knk
Genetic Background: B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Relnrl-tg/Relnrl-tg
Genetic Background: involves: C3H * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: H2-T3tm2.1(CAG-EGFP)Maoh/H2-T3tm2.1(CAG-EGFP)Maoh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1.2Mwst/Smad2tm1.2Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Apctm1Mmt/Apc+,Smad2tm2Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Allelic Composition: Apctm1Mmt/Apc+,Smad2tm1Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Mwst/Smad2tm1.2Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2tm1.2Mwst/Smad2+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Smad2tm1Kato/Smad2tm1Kato
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Smad2tm2Kato/Smad2tm2Kato
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad2tm2.1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

Allelic Composition: Smad2m1Mag/Smad2tm1Rob
Genetic Background: either: (involves: 129S/Sv * 129S/SvEv * Black Swiss) or (involves: 129S/Sv * 129S/SvEv * C57BL/6)

Allelic Composition: Smad2tm1Rak/Smad2tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Kato/Smad2tm1Kato
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Smad2tm2Kato/Smad2tm2Kato
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbatm1Zuk/Inhbatm3Zuk,Inhbbtm1Jae/Inhbbtm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk14tm1Mms/Mapk14tm1Mms
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smad2tm1.1Mwst/Smad2tm1.1Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2tm1.1Mwst/Smad2tm1.2Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Smad2tm2Rob/Smad2tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Smad2m1Mag/Smad2+
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Mmt/Apc+,Smad2tm2Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

Allelic Composition: Apctm1Mmt/Apc+,Smad2tm1Kato/Smad2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst/Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst
Genetic Background: involves: C57BL/6

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm2Knk
Genetic Background: B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm2Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Relnrl-tg/Relnrl-tg
Genetic Background: involves: C3H * C57BL/6 * DBA/2

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0004199 enlarged fetal size "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst/Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst
Genetic Background: involves: C57BL/6

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

 MP:0005032 abnormal ectoplacental cone 
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Smad2tm2.1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Smad2tm1Cxd/Smad2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL

Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smad2tm2.1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodal+,Smad2tm1.1Epb/Smad2+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Epb/Smad2tm1.1Epb,Smad3tm1Cxd/Smad3tm1Cxd,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * DBA * SJL

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0009331 absent primitive node "absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009373 abnormal cumulus expansion "defective or reduced ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Smad2tm1Cxd/Smad2tm1.1Mwst,Smad3tm1Par/Smad3tm1Zuk
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009992 abnormal cerebellum vermis lobule IX morphology 
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009997 abnormal cerebellum vermis lobule X morphology 
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Allelic Composition: Smad2tm1.1Nomu/Smad2tm1.1Nomu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relnrl-tg/Relnrl-tg
Genetic Background: involves: C3H * C57BL/6 * DBA/2

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Emx1tm1Sia/Emx1tm1Sia,Emx2tm1Sia/Emx2tm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad2tm1Cxd/Smad2tm1Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

Allelic Composition: Smad2tm5(SMAD2)Rob/Smad2tm5(SMAD2)Rob
Genetic Background: involves: 129S/SvEv

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

Allelic Composition: Smad2tm1Rak/Smad2tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

Allelic Composition: Smad2tm1Mwst/Smad2tm1.2Mwst
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Smad2m1Mag/Smad2tm1Rob
Genetic Background: either: (involves: 129S/Sv * 129S/SvEv * Black Swiss) or (involves: 129S/Sv * 129S/SvEv * C57BL/6)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Smad2tm1Enl/Smad2tm1Enl
Genetic Background: involves: 129S4/SvJae

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0012084 truncated foregut "shortened foregut that terminates abruptly as if having an end or point cut off" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0012170 absent optic placodes "absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [MGI:anna]
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Allelic Composition: Smad2m1Mag/Smad2m1Mag
Genetic Background: either: (involves: 129S/Sv * Black Swiss) or (involves: 129S/Sv * C57BL/6)

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst/Cdh5tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst
Genetic Background: involves: C57BL/6

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0012245 abnormal hepatoblast migration "atypical migration of hepatoblasts across the basement membrane of the liver bud and/or invasion of the neighboring septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Smad2tm1Cxd/Smad2+,Smad3tm1Cxd/Smad3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Smad2tm1Enl/Smad2+
Genetic Background: involves: 129S4/SvJae

 MP:0012724 failure of head fold formation "inability to form the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; the head fold constitutes the first body fold, and initiates brain, foregut and heart development" [MGI:anna]
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Allelic Composition: Ltatm1Tab/Ltatm1Tab
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CF-1)

 MP:0013207 absent endoderm "absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

 MP:0013216 absent ectoderm "absence of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm1Rob
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000532 Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*  / reaction
 ENSMUSG00000009555 Cdk9 / Q99J95 / Cyclin-dependent kinase 9 / P50750*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction / complex
 ENSMUSG00000011960 Ccnt1 / Q9QWV9 / Cyclin-T1 / O60563*  / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / reaction
 ENSMUSG00000027660 Skil / Q60665 / SKI-like / P12757* / SKI like proto-oncogene*  / complex / reaction
 ENSMUSG00000001280 Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*  / complex / reaction
 ENSMUSG00000029478 Ncor2 / Q9WU42 / Nuclear receptor corepressor 2 / Q9Y618*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000018401 Mtmr4 / Q91XS1 / Mus musculus myotubularin related protein 4 (Mtmr4), transcript variant 2, mRNA. / Q9NYA4* / myotubularin related protein 4*  / reaction / complex
 ENSMUSG00000038400 Pmepa1 / prostate transmembrane protein, androgen induced 1 / Q969W9*  / reaction / complex
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000029050 Ski / SKI proto-oncogene / P12755*  / reaction / complex
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction
 ENSMUSG00000021096 Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*  / reaction / complex
 ENSMUSG00000026349 Ccnt2 / Q7TQK0 / Cyclin-T2 / O60583*  / reaction
 ENSMUSG00000026834 Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*  / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction / complex
 ENSMUSG00000034557 Zfyve9 / zinc finger, FYVE domain containing 9 / O95405* / zinc finger FYVE-type containing 9*  / reaction
 ENSMUSG00000029635 Cdk8 / Q8R3L8 / Cyclin-dependent kinase 8 / P49336*  / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction / complex
 ENSMUSG00000033837 Foxh1 / O88621 / Forkhead box protein H1 / O75593* / forkhead box H1*  / complex / reaction
 ENSMUSG00000024947 Men1 / Menin / O88559 / O00255* / menin 1*  / reaction / complex
 ENSMUSG00000048756 Foxo3 / Q9WVH4 / Forkhead box protein O3 / O43524* / forkhead box O3*  / reaction / complex
 ENSMUSG00000028252 Ccnc / Q62447 / Cyclin-C / P24863*  / reaction
 ENSMUSG00000047407 Tgif1 / P70284 / TGFB-induced factor homeobox 1 / Q15583*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000062175 Tgif2 / Q8C0Y1 / TGFB-induced factor homeobox 2 / Q9GZN2*  / complex / reaction
 ENSMUSG00000021258 Ccnk / cyclin K / O75909*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction / complex






 

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