ENSMUSG00000032440


Mus musculus

Features
Gene ID: ENSMUSG00000032440
  
Biological name :Tgfbr2
  
Synonyms : Q62312 / Tgfbr2 / transforming growth factor, beta receptor II
  
Possible biological names infered from orthology : P37173 / transforming growth factor beta receptor 2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 116084293
Gene end: 116175360
  
Corresponding Affymetrix probe sets: 10597518 (MoGene1.0st)   1422019_at (Mouse Genome 430 2.0 Array)   1425444_a_at (Mouse Genome 430 2.0 Array)   1426397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035014
Ensembl peptide - ENSMUSP00000062333
NCBI entrez gene - 21813     See in Manteia.
MGI - MGI:98729
RefSeq - NM_029575
RefSeq - NM_009371
RefSeq Peptide - NP_033397
RefSeq Peptide - NP_083851
swissprot - Q543C0
swissprot - Q62312
Ensembl - ENSMUSG00000032440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfbr2aENSDARG00000059363Danio rerio
 tgfbr2bENSDARG00000034541Danio rerio
 Q90999ENSGALG00000011442Gallus gallus
 P37173ENSG00000163513Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*ENSMUSG0000006139331
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215530
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*ENSMUSG0000002683426
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*ENSMUSG0000006733626
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761326
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053024
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053224
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*ENSMUSG0000005243024
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683624
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*ENSMUSG0000002179623
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015013  Transforming growth factor beta receptor 2 ectodomain
 IPR017194  Transforming growth factor-beta receptor, type II
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002651 positive regulation of tolerance induction to self antigen IMP
 biological_processGO:0002663 positive regulation of B cell tolerance induction IMP
 biological_processGO:0002666 positive regulation of T cell tolerance induction IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003149 membranous septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003186 tricuspid valve morphogenesis IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0003274 endocardial cushion fusion IMP
 biological_processGO:0003417 growth plate cartilage development IGI
 biological_processGO:0003430 growth plate cartilage chondrocyte growth IMP
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISO
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042493 response to drug ISO
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0043415 positive regulation of skeletal muscle tissue regeneration IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045766 positive regulation of angiogenesis IGI
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0051138 positive regulation of NK T cell differentiation IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060433 bronchus development IMP
 biological_processGO:0060434 bronchus morphogenesis IMP
 biological_processGO:0060439 trachea morphogenesis IMP
 biological_processGO:0060440 trachea formation IMP
 biological_processGO:0060443 mammary gland morphogenesis IMP
 biological_processGO:0060463 lung lobe morphogenesis IMP
 biological_processGO:0070723 response to cholesterol IDA
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:1905317 inferior endocardial cushion morphogenesis IMP
 biological_processGO:1990086 lens fiber cell apoptotic process IDA
 biological_processGO:1990428 miRNA transport IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process ISO
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity ISO
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity ISO
 molecular_functionGO:0005026 transforming growth factor beta receptor activity, type II IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding ISO
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding ISO
 molecular_functionGO:0046332 SMAD binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding ISO


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000678 abnormal parathyroid gland morphology "anomalous structure of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000680 absent parathyroid glands "missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hdac7tm1Eno/Hdac7tm2Eno,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001272 increased metastatic potential 
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tg(Cd4-cre)1Cwi/0,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hprttm1(CAG-Tgfbr1*)Lba/Y,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Tg(Cd4-cre)1Cwi/0,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

 MP:0001889 delayed brain development "the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sp4tm1Ssp/Sp4tm1Ssp
Genetic Background: involves: 129P2/OlaHsd * CF-1

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.1Hlm/Tgfbr2tm1.1Hlm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Acvrl1-cre)L1Spo/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002239 abnormal nasal septum morphology "any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd44tm1Mak/Cd44+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Daxxtm1Maul/Daxxtm1Maul
Genetic Background: involves: 129/Sv

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Cd44tm1Mak/Cd44+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003154 abnormal soft palate "abnormality in the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003494 parathyroid hypoplasia 
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003756 abnormal hard palate "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sp4tm2.1Krc/Sp4tm2.1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004376 absent frontal bone "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sp4tm2.1Krc/Sp4tm2.1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0004540 small maxilla "reduced size of the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004551 decreased tracheal cartilage ring number "less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * NOD * SJL

 MP:0004913 absent mandibular angle "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Foxp3-EGFP/cre)1cJbs/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * NOD * SJL

Allelic Composition: Cd4tm1(cre/ERT2)Thbu/Cd4+,Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0004976 abnormal B-1 B cell number "deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006202 vitreous body hemorrhage "bleeding into the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd4tm1(cre/ERT2)Thbu/Cd4+,Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Endogtm1Vdaw/Endogtm1Vdaw
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: B6.129-Krastm4Tyj Tgfbr2tm1.2Hlm

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0008712 decreased interleukin-9 secretion "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009025 abnormal brain dura mater morphology "any structural anomaly of the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009057 increased interleukin-21 secretion "increase in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+,Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+,Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009625 abnormal abdominal lymph node morphology 
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

 MP:0009653 abnormal palate development "abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009654 abnormal primary palate development "any anomaly in the formation of the part of the shelf separating the oral and nasal cavities that is formed during early embryonic development from the medial nasal processes which derive from the frontonasal process; these merge with each other and with the bilateral maxillary processes to form the upper lip and the primary palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009883 palatal shelf hypoplasia "reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number" [PMID:16680722]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Igf2bp1Gt(OST33739)Lex/Igf2bp1Gt(OST33739)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010452 retina microaneurysm "focal dilation of arteriocapillary junctions in the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010661 ascending aorta aneurysm "a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0010668 abnormal hepatic portal vein morphology "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010988 abnormal bronchial cartilage morphology "any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tg(Cd4-cre)1Cwi/0,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hoxa2tm1Mrc/Hoxa2tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tie1-cre)9Ref/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Eportm1.4Jtp/Epor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tgfbr2tm1.1Hlm/Tgfbr2tm1.1Hlm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011572 abnormal aorta bulb morphology "any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [MGI:csmith, PMID:10722531]
Show

Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0011575 dilated aorta bulb "the luminal space of the aorta bulb is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic Background: 129S6(Cg)-Tgfbr2tm1.1Hcd

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
Show

Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl,Tg(Tagln-cre)1Her/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012236 abnormal cholangiocyte morphology "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0012760 decreased cranial neural crest cell proliferation "reduced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013546 cleft soft palate "a cleft in the soft tissue constituting the back of the roof of the mouth; the soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate to the back of the mouth" [UBERON:0001733]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030224 abnormal soft palate muscle morphology "any structural anomaly of any of the five paired muscles of the soft palate that play important roles in swallowing and breathing; these muscles include the tensor veli palatini, palatoglossus, palatopharyngeus, levator veli palatini, and the musculus uvulae muscles" [https://en.wikipedia.org/wiki/Soft_palate, https://radiopaedia.org/articles/muscles-of-the-soft-palate]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0030283 small mandibular coronoid process "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0030293 small tensor veli palatini muscle "reduced size of the broad, thin, ribbon-like muscle that tenses the soft palate" [MGI:anna]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0030295 small levator veli palatini muscle "reduced size of the paired cylindrical muscle that forms a V-shaped sling behind and above the soft palate; it originates from the apex of the inferior surface of the petrous temporal bone and the medial rim of the auditory tube,
 and inserts into the palatine aponeurosis between the two heads of palatopharyngeus; it elevates and laterally deviates the soft palate; it also aids the tensor veli palatini in opening the auditory tube on swallowing
 to allow equalization of pressure between the middle ear and pharynx" [https://radiopaedia.org/articles/levator-veli-palatini, MGI:anna]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tg(KRT14-cre)52Smr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0030450 abnormal enamel mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030459 abnormal tooth attrition "change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / reaction / complex
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / reaction / complex
 ENSMUSG00000024232 Bambi / Q9D0L6 / BMP and activin membrane-bound inhibitor homolog / Q13145* / BMP and activin membrane bound inhibitor*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / complex / reaction
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / reaction / complex
 ENSMUSG00000032966 Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*  / reaction
 ENSMUSG00000034557 Zfyve9 / zinc finger, FYVE domain containing 9 / O95405* / zinc finger FYVE-type containing 9*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction
 ENSMUSG00000030224 Strap / Q9Z1Z2 / serine/threonine kinase receptor associated protein / Q9Y3F4*  / complex
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / reaction / complex






 

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