ENSGALG00000011442


Gallus gallus

Features
Gene ID: ENSGALG00000011442
  
Biological name :TGFBR2
  
Synonyms : Q90999 / TGF-beta receptor type-2 / TGFBR2
  
Possible biological names infered from orthology : P37173 / Q62312 / transforming growth factor beta receptor 2 / transforming growth factor, beta receptor II
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 39945695
Gene end: 40007802
  
Corresponding Affymetrix probe sets: Gga.2645.1.S1_at (Chicken Array)   Gga.2645.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036896
Ensembl peptide - ENSGALP00000018634
NCBI entrez gene - 396399     See in Manteia.
RefSeq - XM_015281321
RefSeq - NM_205428
RefSeq Peptide - NP_990759
swissprot - Q90999
swissprot - A0A1I7Q417
Ensembl - ENSGALG00000011442
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfbr2aENSDARG00000059363Danio rerio
 tgfbr2bENSDARG00000034541Danio rerio
 P37173ENSG00000163513Homo sapiens
 Q62312ENSMUSG00000032440Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000001205550
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615833
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244432
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845927
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959926
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317926
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200326
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125726
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730126
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563525
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221625


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015013  Transforming growth factor beta receptor 2 ectodomain
 IPR017194  Transforming growth factor-beta receptor, type II
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001654 eye development IEP
 biological_processGO:0001666 response to hypoxia ISM
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001775 cell activation IMP
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002651 positive regulation of tolerance induction to self antigen IEA
 biological_processGO:0002663 positive regulation of B cell tolerance induction IEA
 biological_processGO:0002666 positive regulation of T cell tolerance induction IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003149 membranous septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003186 tricuspid valve morphogenesis IEA
 biological_processGO:0003214 cardiac left ventricle morphogenesis IEA
 biological_processGO:0003274 endocardial cushion fusion IEA
 biological_processGO:0003417 growth plate cartilage development IEA
 biological_processGO:0003430 growth plate cartilage chondrocyte growth IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process ISA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010628 positive regulation of gene expression TAS
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010936 negative regulation of macrophage cytokine production ISM
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration TAS
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032570 response to progesterone ISM
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045216 cell-cell junction organization ISM
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048568 embryonic organ development IEP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048762 mesenchymal cell differentiation TAS
 biological_processGO:0050714 positive regulation of protein secretion ISM
 biological_processGO:0051138 positive regulation of NK T cell differentiation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition TAS
 biological_processGO:0060325 face morphogenesis ISM
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060433 bronchus development IEA
 biological_processGO:0060434 bronchus morphogenesis IEA
 biological_processGO:0060439 trachea morphogenesis IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060443 mammary gland morphogenesis IEA
 biological_processGO:0060463 lung lobe morphogenesis IEA
 biological_processGO:0070483 detection of hypoxia ISM
 biological_processGO:0070723 response to cholesterol IEA
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:1905075 positive regulation of occluding junction disassembly ISS
 biological_processGO:1905317 inferior endocardial cushion morphogenesis IEA
 biological_processGO:1990086 lens fiber cell apoptotic process IEA
 biological_processGO:1990428 miRNA transport IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005886 plasma membrane ISA
 cellular_componentGO:0005901 caveola ISA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISM
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft ISA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity ISA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity IEA
 molecular_functionGO:0005026 transforming growth factor beta receptor activity, type II IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding ISS
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010613 ZFYVE9 / zinc finger FYVE-type containing 9 / O95405* / zinc finger, FYVE domain containing 9*  / reaction / complex
 ENSGALG00000013092 STRAP / Q5ZL33 / Serine-threonine kinase receptor-associated protein / Q9Y3F4* / Q9Z1Z2*  / complex
 ENSGALG00000040993 BAMBI / BMP and activin membrane bound inhibitor / Q13145* / Q9D0L6* / BMP and activin membrane-bound inhibitor homolog *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000011442 Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / complex / reaction
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000027151 FKBP1C / FKBP1A* / P26883* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A* / Peptidyl-prolyl cis-trans isomerase FKBP1A *  / reaction
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction






 

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