ENSGALG00000037301


Gallus gallus

Features
Gene ID: ENSGALG00000037301
  
Biological name :ACVR1
  
Synonyms : Activin receptor type-1 / ACVR1 / Q90ZK6
  
Possible biological names infered from orthology : activin A receptor type 1 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / P37172 / Q04771
  
Species: Gallus gallus
  
Chr. number: 7
Strand: -1
Band:
Gene start: 36448667
Gene end: 36651282
  
Corresponding Affymetrix probe sets: Gga.2875.1.S1_at (Chicken Array)   Gga.2875.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047665
Ensembl peptide - ENSGALP00000064312
Ensembl peptide - ENSGALP00000048067
Ensembl peptide - ENSGALP00000046833
NCBI entrez gene - 395246     See in Manteia.
RefSeq - XM_015290134
RefSeq - XM_015290129
RefSeq - XM_015290130
RefSeq - XM_015290131
RefSeq - XM_015290132
RefSeq - XM_015290133
RefSeq - NM_204560
RefSeq - XM_015290126
RefSeq - XM_015290127
RefSeq - XM_015290128
RefSeq Peptide - NP_989891
swissprot - A0A1D5P5U4
swissprot - A0A1D5P4Q3
swissprot - A0A1D5P2D8
swissprot - Q90ZK6
Ensembl - ENSGALG00000037301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvr1lENSDARG00000014986Danio rerio
 ACVR1ENSG00000115170Homo sapiens
 Acvr1ENSMUSG00000026836Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563550
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125741
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317941
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200341
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959941
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221640
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615826
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144225
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244424
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845923
ENSGALG0000001205523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0003143 embryonic heart tube morphogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003183 mitral valve morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003274 endocardial cushion fusion IEA
 biological_processGO:0003289 atrial septum primum morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042118 endothelial cell activation IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048762 mesenchymal cell differentiation IMP
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060923 cardiac muscle cell fate commitment IEA
 biological_processGO:0061312 BMP signaling pathway involved in heart development IEA
 biological_processGO:0061445 endocardial cushion cell fate commitment IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IEA
 biological_processGO:2000017 positive regulation of determination of dorsal identity IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0048179 activin receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016361 activin receptor activity, type I IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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